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The ESHRE journals had a great year in 2018, remaining at the top of their field for another year, with ever increasing readership from around the world. Discover the 2018 articles we couldn't let you miss in our Best of 2018 collection, featuring papers selected by the journal Editors.
Studying the nuts and bolts of spermatozoa (comment on David Mortimers article on Sperm Function)
When Watson and Crick (1953) first described the 3D structure of the DNA molecule, they showed the now familiar twisted ladder with a right-hand spiral. Yet now, over 60 years later, DNA is often depicted on book covers and in films with a certain amount of poetic licence: the most annoying of which is when the spiral is twisted to the left. It is clearly an easy mistake to make given the ease by which computer graphics packages are able to flip
The functional anatomy of the human spermatozoon: relating ultrastructure and function
This review summarizes the historical and current state of knowledge of mammalian sperm ultrastructure, with particular emphasis on and relevance to human spermatozoa, combining information obtained from a variety of electron microscopic (EM) techniques. Available information on the composition and configuration of the various ultrastructural components of the spermatozoon has been related to their mechanistic purpose and roles in the primary asp
Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes
Result(s): Growth hormone co-treatment increased the receptor density for granulosal FSHR, BMPR1B, LHR, and GHR compared with the non–GH-treated patients of the same age and ovarian reserve. Growth hormone co-treatment increased GHR density, which may increase GHR activity. The GH co-treatment was associated with a significant increase in pregnancy rate
Tracking quality: can embryology key performance indicators be used to identify clinically relevant shifts in pregnancy rate?
This study demonstrates that statistical KPI monitoring systems have the potential to provide systematic, early detection of adverse outcomes in ART laboratories after planned or unexpected shifts in conditions.Day 5 usable blastocyst rate (D5BUR) is an important embryology KPI that complements total usable blastocyst rate (TBUR) in its ability to rapidly identify adverse embryology outcomes, prior to changes in clinical outcomes.
Association of phthalates, parabens and phenols found in personal care products with pubertal timing in girls and boys
In girls, we observed earlier onset of pubic hair development with prenatal urinary MEP concentrations and earlier menarche with prenatal triclosan and 2,4-dichlorophenol concentrations. Regarding peripubertal biomarkers, we observed: earlier breast development, pubic hair development and menarche with methyl paraben: earlier menarche with propyl paraben: and later pubic hair development with 2,5-dichlorophenol. In boys, we observed no associatio
We’ve been using CRISPR for years – now we know how it really works
A storm of criticism met the claimed creation of the first genome-edited children in China last month. One reason is that the twin girls have unpredicted new mutations whose effects are unknown. But it now appears there’s a really easy way to ensure the CRISPR genome editing technique makes far more precise, predictable mutations.
China halts work of gene editor He Jiankui in bid to rescue its scientific reputation
In light of the global outcry against disgraced researcher He Jiankui, China's Vice-Minister of Science and Technology has confirmed his ministry has ordered a halt to the condemned human gene-editing work.The Vice-Minister, Xu Nanping, said he strongly opposed the "shocking and unacceptable" efforts that reportedly produced gene-edited twin girls born earlier this month — the first gene-edited human
A maverick researcher claims to have created GM children -
His stated aim is to protect them from AIDS
The second International Summit on Human Genome Editing, held in Hong Kong this week, was supposed to be a forum in which the idea of editing the genomes of human embryos could be discussed calmly and soberly. Fat chance of that. On November 26th, the day before it opened, one of the scheduled speakers, He Jiankui, an expert in dna sequencing at the Southern University of Science and Technology, in Shenzhen, announced that he had already done it,
Genomic Prediction featured in the Economist
Journalist Ananyo Bhattacharya's article is titled "Baby Steps: A slippery slope towards designer babies
SOON TWO biotechnology firms will begin to offer couples undergoing in vitro fertilisation (IVF) the chance to screen embryos before they are implanted in the mother’s womb. This kind of preimplantation genetic diagnosis has, for nearly 30 years, been widely used to test for chromosomal abnormalities or specific genetic disorders that affect only a single gene, such as cystic fibrosis. MyOme, based in Menlo Park, California, and launching in 2019
Why is growth hormone underutilized for our most difficult IVF couples?
In this issue of Fertility and Sterility, Regan et al. (1) present research findings on granulosa cell (GC) receptor density for growth hormone (GH), FSH, bone morphogenetic protein receptor 1B (BMPR1B), and LH in women with varying age and ovarian reserve undergoing in vitro fertilization (IVF). The authors found that GH receptor density was reduced in the poorer responders, and that GH receptor density increased with age in normal responders bu
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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