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Cell-Free, Embryo-Specific sncRNA as a Molecular Biological Bridge between Patient Fertility and IVF Efficiency
The aim of this study was to analyze the sncRNA expression profile of the spent culture media on day 4 after fertilization and to reveal a relationship with the morphofunctional characteristics of gametes and resultant embryos, in particular, with the embryo development and implantation potential.
Secretome profile selection of optimal IVF embryos by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Conclusion: A simple, direct and rapid analysis of spent culture fluid from blastocysts at the point of embryo transfer can quickly identify optimal embryos with the best chance of achieving ongoing pregnancy. Methods like this, which take less than 20 min to perform, could dramatically improve the approach to embryo selection and live births.
Sperm chromatin structure assay high DNA stainability sperm as a marker of early miscarriage after intracytoplasmic sperm injection
Conclusion(s). There is a small but increased risk of early miscarriage if HDS >15% compared with HDS ≤::15%. This increased risk is seen only after ICSI, not after IVF. These findings suggest that HDS can be used as a predictor of an increased risk of miscarriage in ICSI treatments
Unstable osmolality of microdrops cultured in non-humidified incubators
Conclusions: Mineral oil alone may not adequately prevent gradual changes in the osmolality of low-volume microdrops during extended in vitro culture of human embryos in non-humidified incubators. As a result, the osmolality may increase to high enough levels to stress some human embryos and adversely affect clinical outcomes. We therefore recommend that the stability of osmolality should be given more consideration to ensure optimal culture cond
The relationship between FSH receptor polymorphism status and IVF cycle outcome: a retrospective observational study
The homozygous Ser/Ser genotype of FSHR polymorphism at position 680 is associated with a reduced ovarian response to ovarian stimulation in IVF/ICSI. No difference in cumulative live birth rate was found.
Pregnancy following diagnosis of premature ovarian insufficiency: a systematic review
This review reports pregnancy rates across studies ranging from 2.2% to 14.2%. Mean age in patients who achieved a pregnancy was 30 years, highlighting that oocyte quality in these patients is likely unaffected. No treatment has thus far shown its superiority in improving fertility in women with POI. Recent advances in options such as in-vitro maturation and stem-cell therapy, however, are likely to be the future of treatment and may generate new
Can novel early non-invasive biomarkers of embryo quality be identified with time-lapse imaging to predict live birth?
MAIN RESULTS AND THE ROLE OF CHANCE
Central PN juxtaposition was associated with a 2-fold increase in the odds of live birth (OR ::= ::2.20: 95% CI, [1.26–3.89]: P ::= ::0.006), while the presence of MNB2cell was associated with half the odds of live birth (OR ::= ::0.51: 95% CI, [0.27–0.95]: P ::= ::0.035). These two parameters were independent of embryo kinetics. The 33 remaining parameters had no signif
Does 4% normal sperm morphology have any predictive value in IVF
Summary
In a study from a Chinese IVF clinic, sperm with <4%normal forms performed poorer in standard IVF inseminations.
Comment
In a small study from a Chinese IVF clinic, cases for day 3 IVF cycles are partitioned by sperm morphology of either above or below 4%, the WHO benchmark value for normal. Since ICSI has been introduced, few clinics provide IVF only services and allow such a comparison to be made. The 4% cut-off for normal sperm morphology was largely based upon a normal distribution of a large number of samples and consequentially is largely epidemiologically based. It represents only the lower end of a normal distribution. However, for many reasons, the WHO standard is applied to IVF cycles to determine the probability of poor fertilisation. A lot of activity is based upon the results of one semen sample assessed by experienced (and others) the most important is whether the doctor should recommend IVF or ICSI insemination. Clearly, it is a very loose parameter for such a decision and since most clinics offer IVF and ICSI, review of the 4% rule is difficult to justify. This is one reason why this small study is of interest.|The authors looked 375 IVF cycles of which 188 proceeded to day 3 transfer. There is no description of why the transfer rate was so low. Notwithstanding this feature, the authors reported that semen samples with less than 4% normal forms had sa statistically lower fertilisation rate and a lower normal (2PN) fertilisation rate. However, the difference in the fertilisation rate was 80% x 84% and for normal fertilisation was 62% x 70%. There was a small effect on the cleavage rate. There was no difference in any pregnancy related parameter.|So even though this was a small study with all the limitations such a study has, the observation was that sperm samples with less than 4% normal forms may have performed slightly poorer but it had no impact of outcome. Note, there was no data on failed fertilisation, etc so there may have been some other non-described significant risks. The reason why this paper aroused interest is that this data should be collected and the normal range for IVF samples should be unequivocally applied rather than a 4% epidemiologically based standard.|
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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