Comment:This week is all about new genetic activity in IVF. In the course of one week, the IVF industry has seen a glimpse of the future with the announcement of the first gene-edited baby followed by the programmes termination. In the same week New scientist reports on the potential polygenetic screening of human embryos for other traits like IQ. The question is how does the IVF industry step up to the challenge of what we all know was coming.
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Biparental Inheritance of Mitochondrial DNA in Humans
A comprehensive exploration of mtDNA segregation in these families shows biparental mtDNA transmission with an autosomal dominantlike inheritance mode. Our results suggest that, although the central dogma of maternal inheritance of mtDNA remains valid, there are some exceptional cases where paternal mtDNA could be passed to the offspring. Elucidating the molecular mechanism for this unusual mode of inheritance will provide new insights into how m
World’s first gene-edited babies announced by a scientist in China
A woman in China has given birth to two genetically edited baby girls, according to the Associated Press news agency. The aim of the experiment was to create children who are immune to HIV, but it hasn’t yet been independently reviewed or verified.
First results from US CRISPR gene editing on human embryos
THE results from the first CRISPR experiments done in the US on human embryos are now out, although the gene-editing technique has already been used in several human embryo studies conducted in China.
Shoukhrat Mitalipov at Oregon Health and Science University and his colleagues used CRISPR to target a genetic mutation that causes thickening of the heart wall. The disorder can lead to heart failure, and is often behind the sudden deaths of appa
Exclusive: A new test can predict IVF embryos’ risk of having a low IQ
THE prospect of creating intelligent designer babies has been the subject of ethical debate for decades, but we have lacked the ability to actually do it. That may now change, thanks to a new method of testing an embryo’s genes that could soon be available in some IVF clinics in the US, New Scientist can reveal.
New techniques may soon make designer babies a reality – are we ready?
IT IS hard to think of an area of science more controversial than the genetics of intelligence. Now it is about to get exponentially more contentious. For a long time, DNA testing couldn’t tell us anything useful about someone’s IQ or any other traits affected by multiple genes, such as diabetes or cancer risk. But new “polygenic” techniques for analysing many genetic regions at once have begun to make this possible. This week, we report on the f
Some rare fathers pass on an extra kind of DNA to their children
The energy-producing structures found in every one of our cells are usually inherited solely from our mother. But doctors in the US have now identified more than a dozen individuals in three different families who have inherited mitochondria from both parents. It appears that these individuals are very rare exceptions to the usual rule, likely because these families harbour mutations that disrupt the mechanism that normally prevents a father’s mi
Largest study of CRISPR-Cas9 mutations creates prediction tool for gene editing
The largest study of CRISPR action to date has developed a method to predict the exact mutations CRISPR-Cas9 gene editing can introduce to a cell. Researchers edited 40,000 different pieces of DNA and analyzed a thousand million resulting DNA sequences to develop the machine learning predictive tool. The new resource will help make CRISPR-Cas9 gene editing more reliable, cheaper and more efficient.
China halts work of gene editor He Jiankui in bid to rescue its scientific reputation
In light of the global outcry against disgraced researcher He Jiankui, China's Vice-Minister of Science and Technology has confirmed his ministry has ordered a halt to the condemned human gene-editing work.The Vice-Minister, Xu Nanping, said he strongly opposed the "shocking and unacceptable" efforts that reportedly produced gene-edited twin girls born earlier this month — the first gene-edited human
The revelation has met with outcry from the scientific community. 'If true, the report is very concerning,' said Dr Kathy Niakan of the Francis Crick Institute in London. 'This would be a highly irresponsible, unethical and dangerous use of genome editing technology. She added: 'Given the significant doubts about safety, including the potential for unintended harmful side-effects, it is simply far too premature to attempt this.'
Experts caution on implications of 'lost embryos' lawsuit
Experts have strongly criticised a claim that embryos lost during a storage tank failure at a fertility clinic were 'people'.
In the aftermath of the embryo storage tank failure at University Hospital Ahuja Medical Centre, Ohio (see BioNews 961), one of the affected couples, Wendy and Rick Penniman, announced that they were suing the clinic. The couple claims that loss of the embryos amounts to 'wrongful death'. Experts have strongly criticis
First genome-edited babies: a very different perception of ethics
Back in the 18th century, British physician Dr Edward Jenner tested his hypothesis that harmless cowpox can prevent deadly smallpox disease on a young boy in exchange for a few coins to his poor parents. In 2018, a Chinese researcher Dr He Jiankui tested genome editing on human embryos in exchange for free IVF treatment. But that's where the parallels end.
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Following the semen droplet displacement procedure, SPERMTRACK eliminates most disadvantages presented by less efficient products found in the market. SPERMTRACK design facilitates its use in the microscope and also during cleaning, manipulation and