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Higher clusterin immunolabeling and sperm DNA damage levels in hypertensive men compared with controls
This pilot study strongly suggests a relationship between hypertension and markers indicative of poor sperm quality. In hypertensive subjects, high levels of clusterin immunolabeling identified a consistent fraction of ejaculated spermatozoa carrying both DNA fragmentation and strong morphological alterations, which was not correlated with age or with sperm cell mortality.
Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes
Thus, Cdk1 is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes. We also found that Cdk1 maintains the phosphorylation status of protein phosphatase 1 and lamin A/C in oocytes in order for meiosis resumption to occur.
Transfers of fresh blastocysts and blastocysts cultured from thawed cleavage embryos are associated with fewer miscarriages
Our study suggested that access to assisted reproduction treatment at a younger age would result in fewer miscarriages and that a practice model that includes transferring blastocyst and freezing cleavage embryos in fresh cycles would result in better outcomes.
A method for semi-automatic grading of human blastocyst microscope images
Semi-automatic grading of human blastocysts by a computer is feasible and may offer a more precise comparison of embryos, reducing subjectivity and allowing embryos with apparently identical morphological scores to be distinguished
The influence of the type of embryo culture medium on neonatal birthweight after single embryo transfer in IVF
Analysis of 358 singletons born after a fresh SET and 159 singletons born after a frozen–thawed SET showed no significant difference between the HTF and Sage® groups in terms of birthweight.
How to kill gamete donation: retrospective legislation and donor anonymity
This paper analyses the arguments for and against a retrospective law on donor anonymity by looking at the conditions that should be respected when two principles (the donor's right to privacy and the child's right to genetic information) have to be balanced. It is concluded that the justification for introducing retrospective law is lacking: the conditions are not fulfilled.
Anti-Müllerian hormone: poor assay reproducibility in a large cohort of subjects suggests sample instability
Our data suggests that AMH may not be stable under some storage or assay conditions and this may be more pronounced with the Gen II assay. The published conversion factors between the Gen II and DSL assays appear to be inappropriate for routine clinical practice. Further studies are urgently required to confirm our observations and to determine the cause of the apparent instability. In the meantime, caution should be exercised in the interpretati
Cleavage stage embryos range from the 2-cell stage to the compacted morula composed of 8–16 cells. The number of blastomeres is used as the main characteristic with the highest predictive value (Van Royen et al., 1999: Alikani et al., 2000: Fisch et al., 2001). Good quality embryos must exhibit appropriate kinetics and synchrony
As the popularity of blastocyst culture increased, so did the need for a morphological scoring system. The blastocyst grading system introduced by Gardner and Schoolcraft in 1999 was quickly adopted by the majority of IVF laboratories.
The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture
The PN morphology changes over time, indicating that the single light microscopy observation approach is deficient in comparison to time-lapse. Although the assessment of the PN morphology does not improve embryo selection, the timing of PNB should be included in embryo selection parameters.
Is there an association between HOST grades and sperm quality?
Integration of HOST into the sperm selection procedure may provide a valuable tool for selection of functional sperm required for ICSI. According to this study, insemination of HOST grade ‘g’ sperm should be avoided during ICSI.
An investigation into the relationship between the metabolic profile of follicular fluid, oocyte developmental potential, and implantation outcome
Differences in the metabolite composition of follicular fluid correlate with the developmental competence of the human oocyte. Therefore, metabolomic profiling of follicular fluid may prove to be an important technique in gamete/embryo selection.
New Practice Model May Reduce Miscarriage After Assisted Reproduction
A new article in the December issue of Reproductive BioMedicine Online about miscarriage rates following IVF treatment with frozen thawed embryos which may revolutionize clinical and laboratory practice
Freezing All Embryos in IVF With Transfer in a Later Non-Stimulated Cycle May Improve Outcome
There is growing interest in a "freeze-all" embryo policy in IVF. Such an approach, which cryopreserves all embryos generated in a stimulated IVF cycle for later transfer in a non-stimulated natural cycle, would avoid any of the adverse effects which ovarian stimulation might have on endometrial receptivity during the treatment cycle. Ovarian stimulation has been shown to have adverse effects on endometrial receptivity and the risk of ovarian hy
New Test Can Better Predict Successful IVF Embryos, Scientists Say
Scientists at University College Dublin have discovered a new way of measuring the potential success rate of an embryo before it is transferred back into the womb during in vitro fertilisation (IVF).
Discovery of a Molecule That Initiates Maturation of Mammalian Eggs Can Lead to More IVF Pregnancies
Women who have eggs that cannot mature will not become pregnant, and they cannot be helped by in vitro fertilization (IVF). Now researchers at the University of Gothenburg have identified a molecule called Cdk1 that has an important function for mammalian egg maturation. In the future this could lead to an increased rate of successful IVF.
Survey:Laboratory Environment, Air Flow & Contamination [This link may be from a sponsor]
Comment:This survey has been developed in conjunction with Katy Worrilow (LifeAire)and explores the management of the atmosphere and other environmental parameters in your IVF laboratory?
2012 IVF Laboratory Census [This link may be from a sponsor]
will improve accountability.You can submit answers linked to your IP address but they may not be utilised. REGISTER NOW
Comment:I know this is incomplete but FertAid wishes to conduct an annual census of IVF Laboratory activities. Many will not apply but please complete all questions. One reply per lab please. If you register first then you can review the results.
Survey: PH Measurement In The IVF Laboratory [This link may be from a sponsor]
Comment:Recent discussions in EmbryoMail have centred around the measurement of pH. Should you use a CO2 monitor or a pH meter? This survey seeks to canvass the current status of pH measurement in the IVF laboratory.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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November, 2025 and November, 2025
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