Comment:Links to articles on minimal FSH during coasting and renewed arguments about oocyte stem cells. Also I have started a new survey on blastocyst vitrification if you are interested. There is also a link to a good article on PLCζ (what`s this you say?)
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How a Low-Protein Diet Predisposes Offspring to Adulthood Hypertension
Studies have shown that the offspring of mothers on a low-protein diet are more likely to develop hypertension as adults. Now, University of Texas report that in rats, the high maternal testosterone levels associated with a low-protein diet are caused by reduced activity of an enzyme that inactivates testosterone, allowing more testosterone to reach the fetus and increase the offspring's susceptibility to adulthood hypertension.
In-vitro culture of human embryos with mechanical micro-vibration increases implantation rates
The effect of mechanical micro-vibration on embryos during their in-vitro culture was examined. Pregnancy rates after the transfer of embryos in the group with in-vitro culture under mechanical vibration were increased.
Advances in embryo culture platforms: novel approaches to improve preimplantation embryo development through modifications of the microenvironment
Reduced volume systems that reduce embryo spacing, such as the well-of-the-well approach, appear beneficial, although more work is needed to verify the source of their true benefit in human embryos. Emerging microfluidic technology appears to be a promising approach. However, along with the work on specialized culture surfaces, more information is required to determine the impact on human embryo development.
Rethinking In Vitro Embryo Culture: New Developments in Culture Platforms and Potential to Improve Assisted Reproductive Technologies
Furthermore, methods that permit precise and regulated dynamic embryo culture with fluid flow and embryo movement are now available, and novel culture surfaces are being developed and tested.While several factors remain to be investigated to optimize the efficiency of embryo production, manipulation of the embryo culture microenvironment through novel devices and platforms may offer a pathway toward improving embryo development within the laborat
Serum FSH Levels in Coasting Programmes on the hCG Day and Their Clinical Outcomes in IVF ± ICSI Cycles
The optimal FSH cut-off level for LBR and CPR is 5.6 :IU/L on the hCG day. The optimal cutoff for coasting is 4 days. Conclusion(s). Coasting may be continued as long as either serum FSH level is > 2.5 :IU/L on the hCG day without compromising the LBR and CPR or to maximum of 4 days.
Comparison of Naturally Conceived and IVF-DZ Twins in the Netherlands Twin Registry: A Developmental Study
Results showed no differences in growth, in attainment of motor milestones, and in behavioral development between IVF and matched NC twins. It can be concluded that for nearly all aspects, development in IVF and NC children is similar.
Trichorionic Quadruplet Delivered Beyond 36 Weeks of Gestation: A Case Report and Literature Review
A couple conceived with a quadruplet after transfer of three embryos through ICSI. At 36 weeks and 2 days of gestation, the mother developed gestational induced hypertension and delivered the next day by caesarean section. Pathology confirmed the zygosity to be trichorionic quadramniotic and all four babies were discharged home with their mother on postoperative day 3
Antichlamydial Antibodies, Human Fertility, and Pregnancy Wastage
There is a close correlation between antichlamydial antibodies in females and tubal factor infertility: the closest associations have been found for antibodies against chlamydial heat shock proteins. The antibodies have also been shown to be useful among infertile patients with prior ectopic pregnancy, and correlated with poor IVF outcomes & early pregnancy loss.
Infant Feeding Practices and Nut Allergy over Time in Australian School Entrant Children
There was a positive association between parent reported nut allergy and breast feeding. A protective effect was found in children who were fed foods other than breast milk in the first six months. Conclusion. Children were at an increased risk of developing a parent-reported nut allergy if they were breast fed in the first six months of life.
The notion of a “biological clock” in women arises from the fact that oocytes progressively decline in number to the point of exhaustion as females get older, along with a decades-old dogmatic view that oocytes cannot be renewed in mammals after birth [1]. This latter thinking was challenged in 2004 when Tilly and colleagues [2], then others [3], reported that the rate of oocyte loss through follicular atresia and ovulation was much higher than t
Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation
Together, these data provide mechanistic insights into the epigenetic pathways that are responsible for chromatin plasticity in embryonic stem cells, and indicate that the genome's epigenetic state modulates chromatin plasticity and differentiation potential of embryonic stem cells.
Preliminary clinical outcome of novel strategy for the maximization of cumulative pregnancy rates per retrieval in normal responders
GnRH antagonist protocol with GnRH agonist trigger followed by frozen-thawed blastocyst transfers with LZD can generate many blastocysts without OHSS and maximize cumulative pregnancy rates per retrieval. This strategy is more effective in young women aged less than 35 than in women aged 35 to 39.
Cumulative Live-Birth Rates after In Vitro Fertilization
Among 6164 patients undergoing 14,248 cycles, the cumulative live-birth rate after 6 cycles was 72% (95% confidence interval [CI], 70 to 74) with the optimistic analysis and 51% (95% CI, 49 to 52) with the conservative analysis.
Oocyte activation and phospholipase C zeta (PLCζ::): diagnostic and therapeutic implications for assisted reproductive technology
It is clear that PLCζ:: plays a fundamental role in the activation of mammalian oocytes, and that genetic, molecular, or biochemical perturbation of this key enzyme is strongly linked to human infertility where oocyte activation is deficient. Consequently, there is significant scope for our understanding of PLCζ:: to be translated to the ART clinic, both as a novel therapeutic agent with which to rescue oocyte activation deficiency (OAD)
Toward a Better Understanding of Functional Ovarian Reserve: AMH (AMHo) and FSH (FSHo) Hormone Ratios per Retrieved Oocyte
FSHo, but not AMHo, was, overall, statistically associated with pregnancy chances in IVF. This association was further limited to women above age 38 yr. FSHo was also significantly associated with pregnancy chances in women with normal FMR1 genotype, although only almost reaching significance with heterozygous-normal/low.
Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm
We used the data to test for meiotic drive and found evidence for gene conversion. High-throughput sequencing on 31 single cells was used to measure the frequency of large-scale genome instability, and deeper sequencing of eight single cells revealed de novo mutation rates with distinct characteristics.
Entire Genetic Sequence of Individual Human Sperm Determined
The entire genomes of 91 human sperm from one man have been sequenced by Stanford University researchers. The results provide a fascinating glimpse into naturally occurring genetic variation in one individual, and are the first to report the whole-genome sequence of a human gamete - the only cells that become a child and through which parents pass on physical traits.
Certain Jobs Dads Do Linked to Higher Risk of Birth Defects
Jobs associated with specific types of defect included artists (mouth, eyes and ears, gut, limbs, and heart): photographer and photo processors (cataracts, glaucoma, absence of or insufficient eye tissue): drivers (absence of or insufficient eye tissue, glaucoma): landscapers and groundsmen (gut abnormalities).
Do Ovaries Continue to Produce Eggs During Adulthood?
A compelling new genetic study tracing the origins of immature egg cells, or 'oocytes', from the embryonic period throughout adulthood adds new information to a growing controversy. The notion of a "biological clock" in women arises from the fact that oocytes progressively decline in number as females get older, along with a decades-old dogmatic view that oocytes cannot be renewed in mammals after birth.
Mechanisms That Allow Embryonic Stem Cells to Become Any Cell in the Human Body Identified
The authors believe that chromatin plasticity is tantamount to functional plasticity since chromatin is made up of DNA that includes all genes and codes for all proteins in any living cell. Understanding the mechanisms that regulate chromatin function will enable intelligent manipulations of embryonic stem cells in the future.
Unprecedented Snapshot of Single Sperm Cell's Genome
researchers provide a detailed picture of how the cell's DNA varies in a new study published in the July 20, 2012 issue of the Cell Press journal Cell. The techniques used could be helpful for understanding male reproductive disorders or, when applied to other areas of research, for characterizing normal and diseased cells in the body
Study linking breastfeeding to nut allergy 'ridiculous'
Claims that exclusive breastfeeding and eating nuts during pregnancy are leading to an increased incidence of allergies are ridiculous and run counter to the bulk of allergy research, according to an Australian expert.
Survey:Blastocyst Vitrification [This link may be from a sponsor]
Comment:Many clinics routinely vitrify blastocysts but there is little information on how often the cavity is collapsed before vitrification and hatched after warming. This quick survey seeks to find out how common these techniques are.
IVFCPD Module #7 - Understanding Failed Fertilisation [This link may be from a sponsor]
This is a review and summary of an article by Swain and Pool (2008) on the reasons for fertilisation failure. When completed, the participant may have a better understanding why fertilisation sometime does not work. Appropriate for nursing and scientific staff.
2012 IVF Laboratory Census [This link may be from a sponsor]
will improve accountability.You can submit answers linked to your IP address but they may not be utilised. REGISTER NOW
Comment:I know this is incomplete but FertAid wishes to conduct an annual census of IVF Laboratory activities. Many will not apply but please complete all questions. One reply per lab please. If you register first then you can review the results.
Collapsing And Hatching Vitrified Blastocysts [Forum/Discussion]
Blastocyst vitrification has changed IVF practise in recent years but two technical issues remain: pre-vitrification collapsing of the cavity and post warming hatching.
Schematic representation of the current understanding of PLCζ: mechanism of action
Following sperm/oocyte fusion, PLCζ: is released into the cytoplasm of the oocyte, where it facilitates the hydrolysis of membrane-bound PIP2 to DAG and IP3, triggering Ca2+ release from intracellular Ca2+ stores, leading to Ca2+ induced Ca2+ release and oocyte activation. The schematic illustrates the previous theory of PLCζ: action upon membrane-bound PIP2, which is now being considered to be organelle-bound. N: Nucleus: PIP2: Phosphoti
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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