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The ovary: basic biology and clinical implications
The classical view of ovarian follicle development is that it is regulated by the hypothalamic-pituitary-ovarian axis, in which gonadotropin-releasing hormone (GnRH) controls the release of the gonadotropic hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and that ovarian steroids exert both negative and positive regulatory effects on GnRH secretion.
Oocytes play a pivotal role in the cycle of human life. As we discuss here, after emerging from germline stem cells in the fetus, they grow in a follicular niche in which development is harmonized for timely ovulation and hormone secretion after puberty. Most human oocytes have poor developmental competence and are peculiarly vulnerable to chromosomal malsegregation, especially as women pass the optimal years of fertility and may begin to turn to
Mammalian preimplantation development, which is the period extending from fertilization to implantation, results in the formation of a blastocyst with three distinct cell lineages. Only one of these lineages, the epiblast, contributes to the embryo itself, while the other two lineages, the trophectoderm and the primitive endoderm, become extra-embryonic tissues
Micronutrients intake is associated with improved sperm DNA quality in older men
Men with higher dietary and supplement intake of certain micronutrients may produce sperm with less DNA damage, especially among older men. This raises the broader question of how lifestyle factors, including higher intakes of antioxidants and micronutrients, might protect somatic as well as germ cells against age-associated genomic damage.
Nutrition Tied to Improved Sperm DNA Quality in Older Men: Healthy Micronutrient Intake Linked to Reduced DNA Fragmentation
A new study led by scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) found that a healthy intake of micronutrients is strongly associated with improved sperm DNA quality in older men. In younger men, however, a higher intake of micronutrients didn't improve their sperm DNA.
Mayo Clinic Marks Its First Births from Time-Lapse Incubator Use for in Vitro Fertilization
Mayo Clinic recently marked its first births resulting from in vitro fertilization using a new time-lapse incubator that minimizes disturbances from human handling as embryos develop and helps fertility specialists better identify the healthiest embryos. Mayo experts say it may improve pregnancy outcomes for all patients receiving IVF.
Most Mutations Come from Dad: New Insights Into Age, Height and Sex Reshape Views of Human Evolution
Humans inherit more than three times as many mutations from their fathers as from their mothers, and mutation rates increase with the father's age but not the mother's, researchers have found in the largest study of human genetic mutations to date.
Small Family Size Increases Wealth of Descendants but Reduces Evolutionary Success
Evolutionary biologists have long puzzled over this because natural selection is expected to have selected for organisms that try to maximise their reproduction. But in industrialised societies around the world, increasing wealth coincides with people deliberately limiting their family size - the so-called 'demographic transition'.
A new study has found a gene that appears to make women happy, but it doesn't work for men. The finding may help explain why women are often happier than men, the research team said.
'Super-fertility' to blame for some recurrent miscarriages, study suggests
Women who repeatedly reject pregnancies may be 'too good' at carrying, research indicates. Recurrent miscarriage [RM], defined as three or more consecutive miscarriages, affects between one and two percent of couples trying to conceive. In more than 50 percent of cases, the causes of RM are unknown.
Life sentence: Palestinian prisoner has son from smuggled sperm
A Palestinian prisoner has reportedly fathered a son after his sperm was smuggled out of an Israeli prison where he was serving a life sentence. Ammar Ziban's wife, Dallal, was artificially inseminated using her husband's sperm and gave birth to a son, Muhannad, in a hospital in Nablus in the West Bank, according to reports.
Belfast fertility clinic to challenge watchdog's ruling
A Northern Irish fertility clinic has protested against a regulatory notice which could mean it may have to stop accepting new patients. Origin Fertility Care in Belfast was inspected by the Regulation and Quality Improvement Authority (RQIA), the health and social care regulatory body for Northern Ireland, which not only flagged concerns about non-compliance with regulations, but noted that, on follow-up, these problems had not been sufficiently
CDP011-Osmolality of culture media [This link may be from a sponsor]
Osmolality is a measure of the pressure exerted by dissolved substances in a solution. Cells in solutions like the fluid of their in vivo environment or in culture media are subject to osmotic pressure. Cells, including embryos, control their sizes by adjusting their intracellular osmotic pressure. This module describes the importance of osmolality and cell volume regulation in embryo culture and viability. On completion, there should be an appre
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
New Developments at FertAid during
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