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Birth characteristics in a clinical sample of women seeking infertility treatment: a case–control study
Conclusions Women born with LBW or SGA seem to suffer an increased risk of infertility due to a female factor. Thus, infants born with birth characteristics that deviate from the norm may be at greater risk of difficulties in childbearing later on in life. Since this study is the first of its kind, more studies are needed to verify the associations found in this study and to determine their nature.
Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial
Interpretation: In women with a tubal pregnancy and a healthy contralateral tube, salpingotomy does not significantly improve fertility prospects compared with salpingectomy.
Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions
We have now revealed the lifelong developmental dynamics of ovarian primordial follicles under physiological conditions and have clearly shown that two classes of primordial follicles follow distinct, age-dependent developmental paths and play different roles in the mammalian reproductive lifespan.
Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression
Here we show that androgens promote follicular development via two mechanisms: (i) prevention of follicular atresia by inducing the expression of an antiapoptotic microRNA (miR), miR-125b: and (ii) promotion of follicle growth by increasing follicle-stimulating hormone receptor levels in a transcription-independent fashion. These data considerably change our understanding of androgen effects in female reproduction, and help explain the ovarian ph
The first clinical uterus transplantation trial: a six-month report
Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, respectively. No immediate perioperative complications occurred in any of the recipients. After 6 months, seven uteri remained viable with regular menses. Mild rejection episodes occurred in four of these patients. These rejection episodes were effectively reversed by corticosteroid boluses. The two graft losses were because of acute bilateral thrombotic ut
Effects of assisted reproductive technologies on human sex ratio at birth
Intrauterine insemination, IVF, and ICSI lead to different sex ratios, highest after IVF (proportion male = mean 0.521 ± confidence interval 0.0056) and lowest under ICSI embryo transfer (0.493 ± 0.0031). In addition, for both ICSI and IVF, transferring embryos at a later stage (blastocyst) results in approximately 6% more males than after early cleavage-stage ET.
Premature ovarian failure is a major cause of female infertility. The genetic causes of this disorder remain unknown in most patients. Using whole-exome sequence analysis of a large consanguineous family with inherited premature ovarian failure, we identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. STAG3 encodes a meiosis-specific subunit of the cohesin ring, which ensures correct sister chromatid cohes
Mutations in HFM1 in Recessive Primary Ovarian Insufficiency
We suggest that mutations in genes encoding proteins that regulate meiosis can result in autosomal recessive primary ovarian insufficiency in humans, although our findings await confirmation by independent groups. However, our results are consistent with the finding that Hfm1-deficient mice are infertile.5 Further investigation of HFM1 in larger series of women with primary ovarian insufficiency and in infertile men is warranted.
Are the eggs produced by adolescent girls the same as the ones produced by adult women? A recent study shows compelling evidence that there are two completely distinct types of eggs in the mammalian ovary - 'the first wave' and 'the adult wave.' The first wave of eggs, which starts immediately after birth, contributes to the onset of puberty and provides fertilizable eggs into the transition from adolescence to adulthood. In contrast, the adult w
Fertility prospects don't increase significantly when fallopian tubes are preserved following ectopic pregnancy
Pregnancy outcomes were observed in a new study with regard to the two surgical treatments for ectopic pregnancy - salpingectomy, in which the affected fallopian tube is removed, or salpingotomy, in which the tube is preserved. Ectopic pregnancy affects 3 percent of all pregnancies and is one of the leading causes of maternal death, but the surgical treatment choices have never been compared head to head before this study.
A genetic cause for premature ovarian failure, a disorder affecting one percent of women that provokes the loss of ovarian function years before menopause, has been found by researchers. "Our work enables us to causally relate mutations in a gene of the cohesin complex with human infertility. It also demonstrates for the first time in humans that POF and azoospermia, a disorder that impedes normal sperm production, are probably the two faces of t
IVF the next step in live-donor uterus transplant project
n the spring of 2013, a team of researchers and doctors performed the last of nine planned uterus transplants. The six-month follow up shows that live-donor uterus transplantation has a low risk despite extended surgery duration. In the next phase of the world-unique research project researchers will help seven of the women become pregnant through IVF treatment. The project is the world's first systematic and research-based attempt to find a trea
Female fertility: What's testosterone got to do with it? Research shows male hormones may enhance IVF therapy
The use of testosterone to improve outcomes in women undergoing in vitro fertilization is taking hold across the country, but data on its use is slim and mixed. A new study suggests that the male hormone might actually be doing something good by helping drive the development of follicles - structures that contain and ultimately release an egg that can be fertilized by a man's sperm. The authors believe the study provides potential biological targ
Girls born small or underweight twice as likely to be infertile in adulthood
Girls born unexpectedly small or underweight seem to be twice as likely to have fertility problems in adulthood as those of normal size at birth, suggests new research. "As medical research and care advances, more infants will be born [with low birthweight or small size] and survive, which in turn might influence future need of infertility treatment," the authors conclude.
Foreigners seek IVF, plastic surgery at Czech clinics
Artificial fertilisation and plastic surgery are the two most frequent types of care foreigners seek at Czech clinics, Ondrej Sebestik, from HealthCzech company, has told CTK adding that this is mainly due to about half-costs and a comparable quality.
Paul Davies has assembled a team of top thinkers to start again on cancer. Paul tells the tale of how he, a cosmologist and theoretical physicist with an interest in astrobiology, was approached to rethink the problem from the ground up [Ed Why use low O2 in embryo culture- the answer is 2/3 the way through this fascinating talk on cancer].
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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