Comment:An excellent review on PGS (Mark 2) by Prof Norbert Gleicher et.al. on the efficiency of Day 5 PGS/Aneuploidy screening. Worth a read. FertAid encourages all staff to subscribe. Spread the word about IVFDaily. We aim to reach over 2,000 subscribers.
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Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial
Interpretation: In women with a tubal pregnancy and a healthy contralateral tube, salpingotomy does not significantly improve fertility prospects compared with salpingectomy.
Birth characteristics in a clinical sample of women seeking infertility treatment: a case–control study
Conclusions Women born with LBW or SGA seem to suffer an increased risk of infertility due to a female factor. Thus, infants born with birth characteristics that deviate from the norm may be at greater risk of difficulties in childbearing later on in life. Since this study is the first of its kind, more studies are needed to verify the associations found in this study and to determine their nature.
Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes
We therefore establish that the activities of SAC proteins and the APC co-exist in oocytes, and such concurrence has a vital role in reducing aneuploidy rates by extending MI, probably by allowing time for numerous erroneous microtubule attachments to be corrected.
Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility
Our results showed that women with unexplained infertility used considerably more folic acid supplements and had higher total folic acid intake from supplements compared with fertile control women. Women with unexplained infertility had better blood folate and homocysteine concentrations than fertile women, but folic acid supplementation or folate status were not related to pregnancy outcome following the infertility treatment. In conclusion, hig
Role of dehydroepiandrosterone in improving oocyte and embryo quality in IVF cycles
A significant increase in mean number of mature follicles was seen in the post-treatment group. There was a significant increase in the number of oocytes retrieved, fertilization rates and, consequently, in the total number of embryos available after treatment with DHEA. More embryos were vitrified post treatment and the overall pregnancy rate was 20%. DHEA resulted in a significant improvement in the numbers of oocytes retrieved, oocytes fertil
Cell lines from morphologically abnormal discarded IVF embryos are typically euploid and unaccompanied by intrachromosomal aberrations
Our data suggest that embryos with abnormal chromosomes resist making cell lines and that abnormalities that arise during cell division are likely to be lost due to competition with normal cells. We also demonstrated that abnormal embryos usually discarded in IVF programmes can provide a valuable source for stem cell lines.
Preimplantation genetic screening (PGS) still in search of a clinical application: a systematic review
Like with PGS#1, the introduction of PGS#2 into unrestricted IVF practice again appears premature, and threatens to repeat the PGS#1 experience, when thousands of women experienced reductions in IVF pregnancy chances, while expecting improvements. PGS#2 is an unproven and still experimental procedure, which, until evidence suggests otherwise, should only be offered under study conditions, and with appropriate informed consents.
Spermatid count as a predictor of response to FSH therapy
FSH therapy patients showed increases in sperm number and motility (both P < 0.001), allowing some couples to undergo intrauterine insemination instead of IVF. - FSH therapy improved pregnancy rate and sometimes allowed less invasive assisted reproduction treatment in well-selected patients. Spermatid count could represent a new parameter to predict response to FSH therapy.
Outcomes of blastocysts biopsied and vitrified once versus those cryopreserved twice for euploid blastocyst transfer
Although it is unconventional to thaw/warm, biopsy, revitrify and rewarm blastocysts for cryopreserved embryo transfer, the results indicate that outcomes are not compromised.
Each of these studies have suggested candidate biomarkers of oxidative stress, among them are DJ-1, PIP, lactotransferrin and peroxiredoxin. Changes in protein concentrations in seminal plasma samples with oxidative stress conditions were related to stress responses and to regulatory pathways, while alterations in sperm proteins were mostly associated to metabolic responses (carbohydrate metabolism) and stress responses. Future studies should in
Novel aspects of the endocrinology of the menstrual cycle
The steroids oestradiol and progesterone are the main regulators: however, nonsteroidal substances, such as inhibin A and inhibn B, also participate. Accumulating evidence has demonstrated that another nonsteroidal ovarian substance, gonadotrophin surge-attenuating factor (GnSAF), plays a key role in the control of LH secretion during the follicular phase and at midcycle, providing thus a novel aspect in the ovarian control of gonadotrophin secr
Live birth using vitrified–warmed oocytes in invasive ovarian cancer: case report and literature review
To our knowledge, this is the first live birth reported using vitrified–warmed oocytes in invasive ovarian cancer. Controversial issues are reviewed and discussed.
Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility
Oxidative stress is the major cause of DNA fragmentation in spermatozoa. Endogenous and exogenous factors that contribute to oxidative stress are discussed and in many cases are easily modifiable. Antioxidants play a protective role, although a delicate balance of reduction and oxidation is required for essential sperm function, including fertilization. Reducing oxidative stress may improve a couple’s chances of conception either naturally or vi
Basic research in PCOS: are we reaching new frontiers?
It is suggested that theca cells from PCOS ovaries may be more responsive to insulin than cells from non-PCOS ovaries. In this article we review the efforts to define the genes responsible for the syndrome and the studies at the cell function level, as well as animal models, which have been done to elucidate the underlying mechanism that leads to PCOS. Overall, it appears that despite the impressive amount of data that have been generated in the
The altered pharmacokinetics of cetrorelix in obese women may lead to premature ovulation during ART, and this could be one of the mechanisms that results in increased cycle cancelation in this group of women. In accordance with the higher gonadotropin requirements for obese women undergoing ART, weight-based dosing of GnRH antagonists may be required.
Standard IVF medication dose less effective in obese women
Obese women may need a different dose of medication than normal weight women in order to successfully have their eggs harvested for in vitro fertilization (IVF), according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Moroccan Official Warns Against Human Cells Trafficking and In Vitro Fertilization
Casablanca- The Secretary General of the Moroccan government (SGG), Driss Dahak, has recently warned against in vitro fertilization and human cells trafficking in Morocco. The SGG addressed last Tuesday, March 18, a number of issues before an audience of trainee judges. Mr. Dahak shed light on issues related to biological innovations and their legal implications in Morocco, according to daily Akhbar Al Yaoum
Claire Hooper is CEO of DuoFertility, a company that's developed a £500 monitoring and advisory device that helps couples conceive naturally. DuoFertility claims couples using its services have a 39 per cent chance of success, compared to 35 per cent if on an IVF cycle. Claire will be speaking at Wired Health on 29 April.
Ferring Pharmaceuticals announced that the FDA has approved a new labeling for Menopur (menotropins for injection) and Bravelle (urofollitropin for injection) stating that both products can be safely mixed and administered in a single injection. This approval makes this mixed protocol as the only combination IVF stimulation gonadotropins to be mixed in a single syringe. A pharmacodynamics study supporting its safety and stability demonstrated tha
Half of families seeking IVF in the UAE want twins despite health risk, experts warn
They say many prospective parents feel twins or triplets were more desirable, that they would complete their family more quickly, or, because of the high cost of fertility treatment, they want multiple births from one cycle of in vitro fertilisation (IVF) and so ask for the implantation of several embryos
`IMPROVED` PREIMPLANTATION GENETIC SCREENING (PGS) NOT PROVEN TO INCREASE IVF SUCCESS RATES, ACCORDING TO SYSTEMATIC REVIEW
In a recent systematic review published by the online medical journal Reproductive Biology and Endocrinology, investigators at the Center for Human Reproduction (CHR) discuss the rising popularity of preimplantation genetic screening (PGS) and warn about uncontrolled use of the procedure in association with in vitro fertilization (IVF), which, in their opinion, still has not demonstrated efficacy in improving IVF outcomes, despite promotions to t
It is estimated that up to 60 per cent of eggs are affected by errors in how their chromosomes divide, making it the leading cause of infertility. Chromosome errors also lead to conditions such as Down Syndrome and early pregnancy loss. By using state-of-the-art imaging techniques, the researchers examined the most important process present in all cells to prevent chromosome errors – the Spindle Assembly Checkpoint (SAC) – and looked at how it be
Foreigners seek IVF, plastic surgery at Czech clinics
Artificial fertilisation and plastic surgery are the two most frequent types of care foreigners seek at Czech clinics, Ondrej Sebestik, from HealthCzech company, has told CTK adding that this is mainly due to about half-costs and a comparable quality.
Girls born small or underweight twice as likely to be infertile in adulthood
Girls born unexpectedly small or underweight seem to be twice as likely to have fertility problems in adulthood as those of normal size at birth, suggests new research. "As medical research and care advances, more infants will be born [with low birthweight or small size] and survive, which in turn might influence future need of infertility treatment," the authors conclude.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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