Comment:Your clinic is invited to subscribe to($AUD250) and enrol your embryology staff in the EQA scheme Embryo Ranking (HER) that tests their embryo grading competncy to rank 3-9 embryos from good to poor. FertAid now has added a challenge to see who can rank embryos closest to the average ranking over 2014. Contact office@fertaid.com for more Info
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Molecular analysis of testis biopsy and semen pellet as complementary methods with histopathological analysis of testis in non-obstructive azoospermia
Conclusions: Molecular analysis of semen does not provide sufficient sensitivity and specificity to be used as a screening test at the present time, but it is a useful adjunct to histopathological methods in men with NOA. Spermatid/sperm specific transcripts indicated the possibility to find mature sperm following repeated multiple testicular sperm extraction (TESE) or microdisection TESE (mTESE).
DHEA pre-treated patients, poor responders to a first IVF (ICSI) cycle: clinical results.
The comparative analysis of the results showed a significant increase in the number of the retrieved oocytes (p < 0.01), of the oocyte quality (p = 0.02) and a reduction of cancelled cycles (p = 0.03). Moreover, after the treatment with DHEA, there was an increase, though non-significant, in the number of embryos, in the fertilization rate, and in the number of pregnancies. CONCLUSIONS: This study confirms the beneficial effects of DHEA in patien
Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis [2013 review]
In conclusion, based on the limited available evidence from a total of approximately 200 IVF cycles, there are insufficient data to support a beneficial role of DHEA as an adjuvant to controlled ovarian stimulation in IVF cycle. Well-designed, randomised controlled trials as well as more exact knowledge about DHEA mechanisms of action are needed to support use of DHEA in standard practice for poor-responders.
Clinical genetic testing for male factor infertility: current applications and future directions
Spermatogenesis involves the aggregated action of up to 2300 genes, any of which, could, potentially, provide targets for diagnostic tests of male factor infertility. Contrary to the previously proposed common variant hypothesis for common diseases such as male infertility, genome-wide association studies and targeted gene sequencing in cohorts of infertile men have identified only a few gene polymorphisms that are associated with male infertilit
Characterization and sorting of flow cytometric populations in human semen
In this study, we show that semen spermatozoa are included in a well-defined, flame-shaped FSC/SSC region (FR), by demonstrating that the count of the spermatozoa contained in such region overlaps that obtained by microscopy in the same samples. In FR, nuclear staining of semen samples reveals three different populations: unstained, brighter and dimmer. Unstained elements were previously characterized as apoptotic bodies of testis origin and the
Lipid concentrations and semen quality: the LIFE study
We found that higher levels of serum total cholesterol, free cholesterol and phospholipids were associated with a significantly lower percentage of spermatozoa with intact acrosome and smaller sperm head area and perimeter. Our results suggest that lipid concentrations may affect semen parameters, specifically sperm head morphology, highlighting the importance of cholesterol and lipid homeostasis for male fecundity.
Assessing sperm chromatin and DNA damage: clinical importance and development of standards
We review some key aspects of the assessment of sperm chromatin quality and DNA damage and identify some of the most widely used tests to monitor these endpoints. An approach to validate three tests by standardizing methodology and determining interlaboratory variation for each test using a standard set of samples is outlined.
Embryological, clinical and ultrastructural study of human oocytes presenting indented zona pellucida
Human oocyte dysmorphisms attain a large proportion of retrieved oocytes from assisted reproductive technology (ART) treatment cycles. Extracytoplasmic defects involve abnormal morphology of the zona pellucida (ZP), perivitelline space and first polar body. The aim of the present study was to describe a novel dysmorphism affecting the ZP, indented ZP.
Atypical embryo phenotypes identified by time-lapse microscopy: high prevalence and association with embryo development
Conclusion(s): Embryos exhibiting atypical phenotypes are highly prevalent in human embryos and show significantly lower developmental potential than control embryos.
X-chromosome inactivation in female newborns conceived by assisted reproductive technologies
Conclusion(s): The assisted reproductive technologies of ICSI and IVF do not appear to affect XCI skewing. Skewing variability within the placentas analyzed supports the theory that weaker selective pressures occur in the placenta that could result in skewed inactivation. Our study is the largest to date to investigate this epigenetic phenomenon in infants conceived by ICSI and IVF alongside age-matched NC controls.
SSRI use during pregnancy linked to autism and developmental delays in boys
In a study of nearly 1,000 mother-child pairs, researchers found that prenatal exposure to selective serotonin reuptake inhibitors (SSRIs), a frequently prescribed treatment for depression, anxiety and other disorders, was associated with autism spectrum disorder and developmental delays in boys.[Pre-conception Pregnancy Advice]
Women who gain too much or too little weight during pregnancy at risk for having an overweight child
Gaining both too much or too little weight during pregnancy appears to increase the risk of having an overweight or obese child, according to a study. In one of the largest studies to examine current Institute of Medicine recommendations regarding pregnancy weight gain in relation to childhood obesity, researchers reviewed the electronic health records of 4,145 racially diverse females who had completed a health survey between 2007 and 2009 and s
Weight loss to improve fertility outcomes: how far should we go?
Obesity is now a pandemic and undoubtedly the greatest burden facing health services worldwide. Twenty percent of women of childbearing age are thought to be obese. It is well-established that, in women, obesity is associated with reduced rates of ovulation, increased miscarriage rates and poor response to ovarian stimulation during assisted conception. Male fertility also appears to be similarly adversely affected with evidence of a reduced ejac
Too many fertility clinics fall short when it comes to counselling [Bionews]
The British Infertility Counselling Association (BICA) recently collaborated with Infertility Network UK on a short survey to get a snapshot of the patient experience of counselling in licensed centres. The results reveal some worrying findings about both the offer and provision of counselling from clinics. Although a small sample (214 patients), this is a very welcome piece of research, which provides some evidence about how counselling is - or
Virtus Health chief executive Sue Channon has questioned whether Primary Health Care could successfully enter the $500 million fertility market, saying the company will struggle to attract specialists and satisfy customers who are wary of low cost offerings. Primary’s potential move in the growing in-vitro fertilisation market came to light after managing director Edmund Bateman told investors of his interest after the medical centre and patholog
IVF patient pregnant with another couple's twins in embryo mix-up
A WOMAN who underwent fertility treatment at a clinic in Rome became pregnant with the twins of another couple after their embryos were mixed up. Italy's health ministry says it's launching an investigation into the error, which was only discovered when the woman was three-months-pregnant.
The mistake happened on December 4, when four different couples were receiving treatment at a specialist fertility unit at the Sandro Pertini Hospital in Rome
Women who donate their eggs so others can have children would be paid for their trouble, under changes to the IVF code of ethics being considered by Australia's chief medical advisory and research authority. As part of its review of the ethical guidelines for the practice of assisted reproductive technology in Australia, the National Health and Medical Research Council has sought public comment on whether women should be ''compensated for the rep
London - A growing number of single women are choosing to undergo fertility treatment in order to have a baby without a partner, figures show. About 632 single women had IVF treatment in 2012, compared to 259 in 2007, according to the Human Fertilisation and Embryology Authority (HFEA). The number of single women having donor insemination increased from 330 to 468 over the same period.
Building on the success and popularity of our pH Meter, RI now offers a new compact version, the pH Meter 3. [This link may be from a sponsor]
The RI pH Meter 3 provides accurate, real-time analysis of media pH within the incubator using its unique custom IVF pH probe. The probe fits into all incubators and allows embryologists to measure the effect of CO2 concentration and other factors on the pH in the media. No more guesswork or assumptions when
Continuous Professional Development Modules-Sample Identification-Dr Steve Fleming
This review will consider the rationale for witnessing, the mode of operation of the main witnessing systems currently available, and the relative strengths and weaknesses of witnessing systems depending upon the manner in which they are applied.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
New Developments at FertAid during
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