Comment:Your clinic is invited to subscribe to($AUD250) and enrol your embryology staff in the EQA scheme Embryo Ranking (HER) that tests their embryo grading competency to rank 3-9 embryos from good to poor. Also see Characterization of follicle stimulating hormone profiles in normal ovulating women;Urinary metabolome identifies signatures of oligozoospermic infertile men; Peri-implantation intercourse lowers fecundability;Meet your unborn child – before it's even conceived; GENEPEEKS
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Potential impact of human mitochondrial replacement on global policy regarding germline gene modification
In this commentary, relevant ethical and biomedical issues are examined and requirements for proceeding with this novel procedure are suggested. Additionally, potentially significant impacts of the UK legalization on global policy concerning germline gene modification are discussed in the context of recent advances in genome-editing technology. It is concluded that international harmonization is needed, as well as further ethical and practical c
Parenting post IVF: is age not so relevant after all?
In 2010, the removal and placing for adoption of an Italian child born by IVF to a father aged 70 and a mother aged 57 provoked lively debate. The Italian courts (including, most recently, the Court of Cassation) have denied that the decision to remove the child was a consequence of her parents’ age. Rather, they claim, her removal was solely motivated by a concern for her welfare, with a range of instances of poor parenting cited in support of t
Proficiency in oocyte retrieval assessed by the learning curve: cumulative summation test
The main outcome measure was the ratio of oocytes collected and follicles aspirated. A trainee’s ratio of 80% of the senior operator’s defined success. From 17 to >50 procedures were necessary for the trainees to reach the predefined level of performance. Cumulative summation tests implemented after the learning phase confirmed that performance was maintained. The present study confirms the large variability in acquiring proficiency for surgical
Multicentre study of the clinical relevance of screening IVF patients for carrier status of the annexin A5 M2 haplotype
Given its importance for patients with RPL, and potentially implantation failure, this study assessed the incidence of carrier status for the M2 ANXA5 haplotype in both the male and female of couples attending five CARE IVF centres. In 314 patients (157 couples), 44% of couples (one or both partners), 24% of females, 26% of males and 37% of couples with unexplained infertility were M2 carriers. This high incidence has provoked further urgent stud
Type of culture media does not affect embryo kinetics: a time-lapse analysis of sibling oocytes
The absence of differences in morphokinetics between two different media concepts validates the algorithm for embryo selection in diverse culture conditions. [ed This compared IVF Global x Sage Media but only to day 3!. A better test would be to day 5- has this been done?/ also suggest universal media=sequential media up to day 3]
Predictive value of androgens and multivariate model for poor ovarian response
. Basal testosterone, instead of DHEAS, was predictive, but with limited ability as a single predictor, for POR. However, the multivariate model of (0.563×Zage)−:(0.505×ZAFC)+(0.506×ZFSH)+(0.34×ZFSH/LH)−:(0.24×Ztestosterone) (ZXi=standardized values of variables) was reliably predictive for POR (ROCAUC=0.976) and pregnancy (ROCAUC=0.716) and was better than antral follicle count for predicting both POR and pregnancy. This multivariate m
Conjugated bisphenol A (BPA) in maternal serum in relation to miscarriage risk
With the 115 women included in the study, there were 47 live births and 68 clinical miscarriages (46 aneuploid and 22 euploid). Median conjugated BPA concentrations were higher in the women who had miscarriages than in those who had live births (0.101 vs. 0.075 ng/mL). Women with the highest quartile of conjugated BPA had an increased relative risk of miscarriage (1.83: 95% CI, 1.14–2.96) compared with the women in the lowest quartile. We found a
Use of fertility treatment modalities in a large United States cohort of professional women
Most women who reported fertility treatment used clomiphene (94%), with a large majority reporting clomiphene as their only form of treatment (73%). Of women who reported treatment more advanced than clomiphene, 13% had used gonadotropin injections alone, 11% IUI treatment, and 11% IVF. Several subgroups were more likely to use multiple treatment modalities and to initiate treatment with gonadotropins rather than clomiphene, including women livin
Characterization of follicle stimulating hormone profiles in normal ovulating women
The individual FSH cyclic profiles demonstrated a significant departure from the currently accepted model. A decline in FSH levels at the end of the follicular phase was observed in only 42% of cycles. The absence of this decline was significantly associated with a shorter luteal phase and higher pregnanediol-3α:-glucuronide, FSH, and LH levels at the time of ovulation. In 34% of the cycles, significant FSH variability was observed throughout
Intercourse during the peri-implantation window may be detrimental to natural fertility. Methods that allow couples to time intercourse to the fertile window may decrease time to pregnancy by not only increasing the probability of fertilization but also decreasing the probability of failed implantation.
Advances in quality control: mouse embryo morphokinetics are sensitive markers of in vitro stress
MKs in mouse embryos are a sensitive and efficient method for quality control testing of in vitro culture conditions. BR, the end-point of traditional quality control assays, did not detect sublethal concentrations of toxins in the culture milieu in our study. This study demonstrates that temporal variation at key developmental stages reflects the quality of the culture environment. An MEA that incorporates MK will provide enhanced sensitivity an
Improved Rodent Maternal Metabolism But Reduced Intrauterine Growth After Vertical Sleeve Gastrectomy
The offspring of dams receiving VSG were born smaller and lighter than offspring of control dams that underwent sham surgery - these adult offspring had a greater propensity to develop glucose intolerance and increased adiposity than the offspring of lean mothers or obese mothers who underwent sham surgery - therefore weight loss alone by obese mothers is not sufficient to reverse the deleterious effects of an HFD and obesity on their offspring.
Urinary metabolome identifies signatures of oligozoospermic infertile men
Oligozoospermic infertile men could be differentiated from fertile control subjects based on altered urinary metabolic profiles. A total of ten potential biomarkers were screened and tentatively identified. Among those, decreased acylcarnitines, aspartic acid, and leucylproline and increased adenine and methylxanthine were strongly associated with oligozoospermic risk. Many biomarkers were associated with sperm concentration and amplitude of late
Fatherhood is not every man's dream, but for those who find themselves unintentionally childless, it's a painful reality. [ed new article on men`s desire to parenthood. The other side of the coin of infertility]
Couples in London and the South East are being denied IVF treatment offered in other parts of the country because of a “geographical lucky dip”, a Conservative MP claims. [ed seems a bit silly really that access to IVF in not a national provision.]
Meet your unborn child – before it's even conceived
A service that creates digital embryos by virtually mixing two people's DNA will allow parents to screen out genetic disorders – and perhaps much more - WILL my baby be healthy? It's a question that concerns every prospective parent. Now a service that creates digital embryos by virtually mixing two people's DNA will give a clearer glimpse of their possible child's health, and perhaps much more – before it has been conceived.[ed brave new world]
Aging linked to cellular interactions that occur across generations
By studying the reproductive cells of nematodes - a researcher identified the Piwi/piRNA genome silencing pathway, the loss of which results in infertility after many generations. This study also found a signaling pathway - a series of molecular interactions inside cells - that could be tweaked to overcome infertility while also causing the worms to live longer adult lives. [ed loss of fertility over generations- is IVF perpetuating it?]
Twin births soar in US due to fertility treatments
IVF is partly responsible for a million extra twins born in the US between 1981 and 2012, according to calculations by The Atlantic. The natural rate of twin births is about 1 in 50. But around 1980 the rate began to rise. By 2012 one baby in 30 was a twin.
MARS acquires Kinder IVF, expands footprint across India through Mangalore
MANGALORE: Manipal Ankur Andrology and Reproductive Services (MARS), chain of fertility focused hospitals has acquired Kinder IVF centre here to deliver specialized service in ambit of andrology, men's health and reproductive medicine in the city. Manipal Ankur having its presence in south and central India, is part of Manipal Health Enterprises. Deputy Commissioner AB Ibrahim and DHO Dr H S Shivakumar inaugurated the revamped clinic at Kadri.
GENEPEEKS - HELPING YOU PROTECT YOUR FUTURE FAMILY [This link may be from a sponsor]
As parents-to-be, we share a fundamental instinct to protect our future children. At GenePeeks we know how that feels. And to be honest, we know how it feels to find holes in the safety net. We started this company to give you safeguards we didn't have when we were starting our own families.
CELL-TEK microscope chambers [This link may be from a sponsor]
The Cell-Tek Microscope Chamber allows embryologists to observe, record and work in a safe controlled environment for oocytes and embryos. It also allows visualisation of the important developmental stages whilst maintaining media pH, temperature and humidity. This work can be performed comfortably and stress free, allowing for a more accurate and reliable assessment of gamete or embryo quality.
Continuous Professional Development Modules-Sample Identification-Dr Steve Fleming
This review will consider the rationale for witnessing, the mode of operation of the main witnessing systems currently available, and the relative strengths and weaknesses of witnessing systems depending upon the manner in which they are applied.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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