Comment:Who wants to live longer by being a eunuch?? Also I continue to be interested in the role of Phospholipase C-ζ:-induced Ca2+ oscillations in fertilisation and embryo development.
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Negative association between androgen receptor gene CAG repeat polymorphism and polycystic ovary syndrome? A systematic review and meta-analysis
In summary, the current systematic review and meta-analysis found that the AR CAG microsatellite repeat polymorphism is unlikely to be a major determining factor in the development of PCOS.
Proficiency testing (PT) serves to supplement existing procedures adopted by facilities to assure the quality and evaluation of performance of the activities for which they are accredited or seek accreditation. A facility’s participation and performance in proficiency testing are reviewed by NATA at assessment.
High-throughput lensfree 3D tracking of human sperms reveals rare statistics of helical trajectories
The large statistics provided by this lensfree imaging platform revealed that only approximately 4–5% of the motile human sperms swim along well-defined helices and that this percentage can be significantly suppressed under seminal plasma. Furthermore, among these observed helical human sperms, a significant majority (approximately 90%) preferred right-handed helices over left-handed ones, with a helix radius of approximately 0.5–3 μ:m, a hel
Phospholipase C-ζ:-induced Ca2+ oscillations cause coincident cytoplasmic movements in human oocytes that failed to fertilize after ICSI.
The occurrence and frequency of cytoplasmic Ca2+ oscillations, a critical parameter in activating human zygotes, can be monitored by PIV analysis of cytoplasmic movements. This simple method provides a novel, noninvasive approach to determine in real time the occurrence and frequency of Ca2+ oscillations in human zygotes.
DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa
Primordial follicle oocytes from mice lacking Puma or both Puma and Noxa were protected from γ::-irradiation-induced apoptosis and, remarkably, could produce healthy offspring. Hence, PUMA and NOXA are critical for DNA damage-induced, TAp63-mediated primordial follicle oocyte apoptosis. Thus, blockade of PUMA may protect fertility during cancer therapy and prevent premature menopause, improving women’s health.
Male Infertility: 'Kick-Starting' Male Fertility With Missing Protein
Adding a missing protein to infertile human sperm can 'kick-start' its ability to fertilise an egg and dramatically increase the chances of a successful pregnancy, a team of University scientists have uncovered. The team from the School of Medicine first found that sperm transfers a vital protein, known as PLC-zeta (PLCz), to the egg upon fertilisation. This sperm protein initiates a process called 'egg activation' which sets off all the biologic
World's first mother-to-daughter womb transplants [BioNews]
Two women in Sweden received uterus transplants from their mothers, with hopes it will allow them to conceive children of their own. A team of ten surgeons completed the first mother-to-daughter womb transplants, which each took seven hours, at the University of Gothenburg in Sweden.
End of legal wrangle involving lesbian parents, private sperm donor and surrogate mother [BioNews]
The High Court has awarded a lesbian couple sole custody rights for a child conceived using donor sperm and a surrogate's egg after a three-year battle over parenthood.The couple, who are both infertile, are friends with the surrogate and she made no claim for the child. However the sperm donor, given the pseudonym of 'Michael' by the Sunday Times, made a claim for legal parenthood.
Sperm swimming patterns revealed by new imaging technology
Scientists have carried out the first large scale, high-resolution recording of human sperm using a new 3D imaging technique. By accurately tracking sperm head movements they discovered that sperm sometimes swim in helices, a movement only previously hinted at by conventional imaging techniques.
Cell Death Discovery Suggests New Ways to Protect Female Fertility
Melbourne researchers have identified a new way of protecting female fertility, offering hope to women whose fertility may be compromised by the side-effects of cancer therapy or by premature menopause
A study of eunuchs in Korea's royal court has found men without testicles live longer. Researchers looking at the court of the Chosun Dynasty found eunuchs lived to 70 on average, or 14 to 19 years longer than "intact" men of similar socio-economic status.
IVFCPD Module #7 - Understanding Failed Fertilisation [This link may be from a sponsor]
This is a review and summary of an article by Swain and Pool (2008) on the reasons for fertilisation failure. When completed, the participant may have a better understanding why fertilisation sometime does not work. Appropriate for nursing and scientific staff.
IVFCPD Module #8 Laboratory Controlled Aspects of IVF Culture Media [This link may be from a sponsor]
Commercial production of culture media has helped standardize this aspect of the IVF laboratory and improved quality control. However, there are still aspects of the culture media, outside of its selection, that are still directly controlled within the laboratory that can impact embryo development. These parameters include pH, temperature and osmolality. Careful attention to detail during media preparation and embryo culture are required to optim
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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