Comment:Mainly from RBMonline this week. Some great articles inc a free access on the predictive value of time-lapse modelling and another article on phospholipase C-zeta . Plus links to articles on cumulative pregnancy rates where FET are included in the outcome. This is a key shift in how one calculates efficacy of IVF. Plus more on the business of IVF. Bit of a worry! Two good patient stories as well.. Note, FertAid has changed its registration process now requires access via a single portal.
Survey-2014 Laboratory Census
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Human PLCζ:: exhibits superior fertilization potency over mouse PLCζ:: in triggering the Ca2+ oscillations required for mammalian oocyte activ
A sperm-specific phospholipase C-zeta (PLCζ::) is believed to play an essential role in oocyte activation during mammalian fertilization. Sperm PLCζ:: has been shown to trigger a prolonged series of repetitive Ca2+ transients or oscillations in oocytes that precede activation. This remarkable intracellular Ca2+ signalling phenomenon is a distinctive characteristic observed during in vitro fertilization by sperm
Heterochromatin variants in human karyotypes: a possible association with reproductive failure
The heterochromatin variants occurred more frequently in the reproductive failure group than in the controls (P = 0.006). Regarding individual chromosomes, chromosome 9 variants were most frequently found in the study and control groups, and they also occurred more frequently in the reproductive failure group. The most significant difference between the study and control groups was found for the 9qh+ variant (P = 0.026), and although the results
Heterochromatin variants in human karyotypes: a possible association with reproductive failure
The heterochromatin variants occurred more frequently in the reproductive failure group than in the controls (P := :0.006). Regarding individual chromosomes, chromosome 9 variants were most frequently found in the study and control groups, and they also occurred more frequently in the reproductive failure group. The most significant difference between the study and control groups was found for the 9qh+ variant (P := :0.026),
Chromosome analysis in embryos from young patients with previous parity
According to the results, informative in 152 couples, the proportion of euploid embryos was significantly lower in 53 nonpregnant women when compared with 99 women with term pregnancy (49% versus 75% respectively, P < 0.001). In addition, in 21 nonpregnant patients, all embryos transferred were found to be chromosomally abnormal. These findings confirmed the limited prediction power of embryo morphology on implantation but also the relevance of c
Impact of high serum progesterone during the late follicular phase on IVF outcome
The aim of this narrative, nonsystematic review is to address the nonconsensual issues of the reasons and consequences of premature progesterone elevation during ovarian stimulation. The determination of the optimal threshold above which progesterone elevation may have an impact on IVF outcome is still a matter of debate because it is likely related to the patient's profile. Additionally, it is still uncertain whether the duration of progesterone
On the cost and prevention of iatrogenic multiple pregnancies
The aim of this study was to determine whether, using real data from a major regional insurance carrier for the interval 2005–2009 covering obstetric costs requiring hospitalization and neonatal costs through the first year, it was possible to show that the cost saved by eliminating iatrogenic multiple births would be adequate to fund a protocol to minimize iatrogenic multiple births. The net savings on an annual basis for the study group of 13,
Quality of additional embryos transferred on pregnancy outcomes in IVF: predictions using a mathematical approach
Transfer of additional embryos, irrespective of embryo quality, always increased pregnancy rate and MPR. When implantation rate was low, there was a marked increase in pregnancy rate but only a relatively small increase in MPR. In contrast, with higher implantation rates, the increase in pregnancy rate was mainly due to the increase in MPR, with the same singleton pregnancy rate. Transfer of additional embryos, irrespective of embryo quality, fol
Is there a critical endometrioma size associated with reduced ovarian responsiveness in assisted reproduction techniques?
Significantly lower numbers of follicles ≥:16 :mm (P = 0.024) and oocytes retrieved (P = 0.001) in the ovaries containing endometrioma were observed. In patients with endometriomas ≥:30 :mm, endometrioma size was the most influential contributor to the total number of follicles and oocytes retrieved. Ovarian endometriomas result in reduced response to ovarian stimulation, compared with the response of the contralateral normal
Coasting, embryo development and outcomes of blastocyst transfer: a case–control study
The duration of coasting up to 4 :days did not affect progression to blastocyst stage. The multivariate model showed that coasting (OR 1.73, P := :0.004) and the number of oocytes retrieved (OR 1.17, P := :0.001) were positively correlated with blastocyst formation. Coasting, a measure to reduce the risk of OHSS, does not impair blastocyst development or clinical outcome. Coasting should remain an effective measure to pre
Comparison of gender-specific human embryo development characteristics by time-lapse technology
A detailed analysis of the data regarding each time point or interval between consecutive events according to these groups showed them to be similar in cell division kinetics, from the early cleavage through their development to blastocyst stage. However, female embryos showed earlier cavitation than male embryos, but the results did not reach statistical significance.
ESHRE Task Force on Ethics and Law 21: genetic screening of gamete donors: ethical issues†
This Task Force document explores the ethical issues involved in the debate about the scope of genetic screening of gamete donors. Calls for expanded donor screening arise against the background of both occasional findings of serious but rare genetic conditions in donors or donor offspring that were not detected through present screening procedures and the advent of new genomic technologies promising affordable testing of donors for a wide range
Freeze-all is a superior therapy to another fresh cycle in patients with prior fresh blastocyst implantation failure
Multiple logistic regression indicated freeze-all was associated with greater cumulative live birth rate than was a fresh cycle (OR 1.9, 95% CI 1.1–3.3, P = 0.0287). These findings suggest that, following implantation failure with fresh blastocysts, patients have a significantly greater chance of live birth with freeze-all and subsequent thaw than with another fresh cycle.
Limitations of a time-lapse blastocyst prediction model: a large multicentre outcome analysis [Open Access]
- but the model's results did not match observations in the test cohort because it rejected a large proportion of embryos from the test cohort that actually resulted in pregnancy. This hypothetical experiment highlights the limitations of predicting blastulation only. Crucially, it illustrates that both sensitivity and specificity are important parameters when developing embryo selection models for prospective clinical use.
Oocyte vitrification in the 21st century and post-warming fertility outcomes: a systematic review and meta-analysis
Oocyte survival, fertilization, cleavage, clinical pregnancy and ongoing pregnancy rates per warmed oocyte were higher in donor versus non-donor studies. Comparing vitrified with fresh oocytes, no statistically significant difference was observed in fertilization, cleavage and clinical pregnancy rates, but ongoing pregnancy rate was reduced in the vitrified group (odds ratio 0.74), with heterogeneity between studies.
Selection of embryos for transfer in IVF: ranking embryos based on their implantation potential using morphological scoring
Five factors were included in the final prediction model: early cleavage, number of blastomeres on days 2 and 3 and morphological score and presence of morula on day 3. With validation, the model showed moderate discriminative capacity (c-statistic 0.70) and calibrated well and was able to distinguish embryos with high ongoing implantation potential from embryos with moderate or low ongoing implantation potential. The model can be used by embryol
Progesterone replacement with vaginal gel versus i.m. injection: cycle and pregnancy outcomes in IVF patients receiving vitrified blastocysts
The IMP and vaginal progesterone gel groups had similar patient demographics for all characteristics assessed. Implantation rates (46.4 versus 45.6%, P = 0.81), clinical pregnancy rates (61.7 versus 60.5%, P = 0.80) and live birth rates (49.1 versus 48.9%, P > 0.99) were not significantly different between IMP and vaginal progesterone gel, respectively.
Global In Vitro Fertilization Market to Reach $21.6 Billion by 2020 - Allied Market Research
Portland, Oregon (PRWEB UK) 26 May 2014
Allied Market Research today published a new market research report titled "In Vitro Fertilization (IVF) Market - Size, Share, Trends, Opportunities, Global Demand, Insights, Analysis, Research, Report, Company Profiles, Segmentation and Forecast, 2013 - 2020." As per the study, the global IVF market is expected to grow at a CAGR of 11.6% between 2013 and 2020. The market revenue of $9.3 billion in 201
Patric is fighting a California law that limits parental rights of most sperm donors. After Gus was born, Schreiber and Patric did not live together, although she did visit Patric in New York. Gus called Patric "Dada." When the couple split for good in 2012, Patric sued for joint custody, and Schreiber withheld visits.
Born survivors: Twins whose mother had chemotherapy, radiotherapy and a mastectomy while they were in the womb - and just look how they are thriving n
They may not look it, but these twins are a real pair of fighters - having survived months of chemotherapy while in the womb.
Their mother Sarah Pierce was 16 weeks pregnant when doctors broke the terrible news that she had breast cancer. The only chance of saving her life was aggressive chemotherapy, but she was terrified that the unborn twins would not survive.
Monash IVF, which achieved the world’s first in-vitro fertilisation pregnancy in 1973, plans to raise as much as $298.4 million through an initial public offering, reporting by Data Room has discovered. The Melbourne-based company plans to sell 153m to 162m shares at $1.65 to $1.95 each, or between 15.1 times and 17 times 2015 forecast earnings per share.
Continuous Professional Development Modules-Sample Identification-Dr Steve Fleming
This review will consider the rationale for witnessing, the mode of operation of the main witnessing systems currently available, and the relative strengths and weaknesses of witnessing systems depending upon the manner in which they are applied.
Staff Logbook. FertAid has developed an online activities logbook for all IVF personnel. There is a list of common procedures available but you are able to create a personalized activity list. You may log the number of cases each quarter and after authorization by your supervisor may be used for certification or competency by your clinic. There is no cost for this module.
FertAid has released the 2014 laboratory census. The aim is to provide clinics with a sense of what others are doing and how their activity compares to others.
The link contains a news story about sperm donors seeking to have access to children conceived from their sperm donation.
Comment
In most countries, the act of sperm donation is covered by laws that define the sperm donor as no legal rights to children conceived from its use. However, where the donor is know to the recipient, there may be some areas where access rights may be questioned. Does the clinic have a role in ensuring that donors and recipients seek written legal advice before the insemination. One wonders if a clinic may be exposed to legal consequences if they fail to ensure that all parties have a binding legal contact and not just rely on the law that is designed for anonymous donation?
Title
Development of models for use of time-lapse embryos for transfer
Summary
Kirstine Kirkegaard et. al article in RBMonline (see link) reports on a multicentre study using cleavage rates (C1,C2,C3) to identify embryos for transfer
Comment
The study used a model developed by Conaghan et al.(2013) to predict blastocyst development using cleavage time cutoff. The study showed that embryos choosen under this model had a high implantation rate (22%). This was fine expect that the embryos that were rejected as cleaving outside the model set points also had an implantation rate of 14%. The authors discussed a model predicting blastulation may not be the same as implantation and the model, if rigorously applied, may lead to a significant number of forgone pregnancies. Maybe the newer models may include set point to day 5 and improve predictability but there does suggest concerns if the model was applied without due diligence. Comments?
Title
2014 IVF Laboratory census
Summary
FertAid opens an annual laboratory census on the activities of an IVF laboratory.
Comment
You are invited to complete the activity of your laboratory. When completed, you can review the results both for all replies and for your own country.
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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