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Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case–control study
Daughters of mothers affected by hyperandrogenic PCOS seem to have a higher risk for PDDs probably due to an unbalanced prenatal exposure to high levels of testosterone.
Autism and Mental Retardation Among Offspring Born After In Vitro Fertilization [FREE]
Compared with spontaneous conception, IVF treatment overall was not associated with autistic disorder but was associated with a small but statistically significantly increased risk of mental retardation. For specific procedures, IVF with ICSI for paternal infertility was associated with a small increase in the RR for autistic disorder and mental retardation compared with IVF without ICSI. The prevalence of these disorders was low, and the increas
Are children born after assisted reproductive technology at increased risk of autism spectrum disorders? A systematic review
At present, there is no evidence that ART is significantly associated with ASD and hence that current health policies should be modified. The divergent results of some of the studies suggest that further prospective, large and high-quality studies are still needed.
These results provide the first direct evidence of elevated fetal steroidogenic activity in autism. Such elevations may be important as epigenetic fetal programming mechanisms and may interact with other important pathophysiological factors in autism.
Preconception Zinc Deficiency Disrupts Postimplantation Fetal and Placental Development in Mice
Zinc is an essential nutrient for optimal fertility, but the effects of preconception zinc deficiency on postimplantation development are not known. Collectively, the findings provide evidence for the importance of preconception zinc in promoting optimal fertility and oocyte developmental potential.
Direct Real-Time Measurement of Intra-Oocyte Nitric Oxide Concentration In Vivo
Nitric oxide (NO) is reported to play significant a role in oocyte activation and maturation, implantation, and early embryonic development. - This experiment suggests that the NO levels of oocytes obtained from young animals are significantly higher than those of oocytes obtained from old animals.
Seminal fluid and reproduction: much more than previously thought
It is now reported that an absence of seminal plasma at conception in mice promotes increased fat accumulation, altered metabolism and hypertension in offspring. The evidence reviewed here demonstrates that seminal plasma is not simply a transport medium for sperm, but acts also as a key regulator of the female tract environment providing optimal support for the developing embryo and benefiting future health of offspring.
Effect of red light on the development and quality of mammalian embryos
Our results indicate that red light (625 nm, 0.34 W/m2) used in the time-lapse incubation system does not decrease the development and quality of blastocysts in both mouse zygotes and porcine PA embryos (both zona-intact and zona-free).
Possible selection of viable human blastocysts after vitrification by monitoring morphological changes
Data of the present study suggest a group of shrunken blastocysts contains many viable and clinically available embryos and time-lapse observation of vitrified–warmed blastocysts is a potential method to distinguish viable embryos from shrunken blastocysts.
Influence of interpregnancy interval on birth timing
While short IPI is a known risk factor for preterm birth, our data show that inadequate birth spacing is associated with decreased gestational age for all births. Pregnancies following short IPIs have a higher frequency of birth at all weeks of gestation prior to 39 and fewer births ≥::40 weeks, resulting in overall shortened pregnancy duration.
Zinc deficiency before conception disrupts fetal development
Female mice deprived of dietary zinc for a relatively short time before conception experienced fertility and pregnancy problems more than mice that ingested zinc during the same times, according to researchers. Zinc deficiency caused a high incidence of pregnancy loss, and embryos from the zinc-deficient diet group were an average of 38 percent smaller than those from the control group. Preconception zinc deficiency also caused approximately half
Risk of preterm birth: Short intervals between pregnancies result in decreased pregnancy length
Women who have short intervals between pregnancies of less than 18 months are more likely to see a decrease in the length of subsequent pregnancies, finds a new study. The study looked at 454,716 live births from women with two or more pregnancies over a six year period. The researchers looked at the influence of inadequate birth spacing on the duration of the subsequent pregnancy.
Clues to stillbirths may be found in marmoset monkeys
The marmoset monkey may offer clues to reducing stillbirths in human mothers, according to new research. The marmoset, a squirrel-sized monkey indigenous to South America, reaches sexual maturity by 15 months of age. They have multiple births, usually twins and triplets. Adult females who were born into triplet litters get pregnant just as often as twin females, but they lose three times as many fetuses. Nearly half of the losses occur during lab
Breast cancer patients could avoid infertility with new drug: study
A new treatment may help breast cancer patients undergoing chemotherapy avoid infertility and early menopause, researchers have found. A study involving 218 women worldwide found monthly injections of the drug goserelin induces a temporary menopause that shuts down the patient's ovaries.
Preventing early menopause in breast cancer patients with new drug treatment
Among young breast cancer patients, one of the most distressing side effects of chemotherapy is early menopause. But a major study finds the risk of early menopause can be significantly reduced by adding the drug goserelin to the chemotherapy regimen.
The country’s largest fertility medicine business, Virtus Health, will have an Asian footprint within six months, chief executive Sue Channon says.
11.27am - Fresh from making the company’s first international foray, inking a deal on Friday to buy a 70 per cent stake in Irish in vitro fertilisation clinic SIMS IVF for €15.49 million ($22.7 million), Ms Channon said further acquisitions were imminent.[Ed interesting movements in the boardrooms]
Children with autism have elevated levels of steroid hormones in the womb
Scientists have discovered that children who later develop autism are exposed to elevated levels of steroid hormones (for example testosterone, progesterone and cortisol) in the womb. The finding may help explain why autism is more common in males than females, but should not be used to screen for the condition.
Sperm-inspired robots controlled by magnetic fields may be useful for drug delivery, IVF, cell sorting and other applications
A team of researchers has developed sperm-inspired microrobots, which consist of a head coated in a thick cobalt-nickel layer and an uncoated tail. When the robot is subjected to an oscillating field of less than five millitesla, it experiences a magnetic torque on its head, which causes its flagellum to oscillate and propel it forward. The researchers are then able to steer the robot by directing the magnetic field lines towards a reference poin
TVM Capital Healthcare Partners expands into India
TVM Capital Healthcare Partners, the MENA region’s first private equity firm dedicated to the healthcare sector, has announced the addition of Sudhir Bahl as an Executive-in-Residence in Dubai and Director India. The appointment comes after TVM Capital Healthcare Partners recently rebranded to reflect the expansion of its investment geography beyond the MENA region and announced its intention to invest up to $100 million in India over the next th
Fertaid Mail - FertAid Interact. [This link may be from a sponsor]
FertAid is developing a new interactive module where items can be listed for discussion, products can be promoted, jobs, etc. It is envisaged the module will be open to all IVF Clinic staff not just embryology.
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Comments Linked to this Mailout
Title
Monash And Virtus Movement
Summary
A note from the SMH details the movement of both private IVF Companies into the International market.
Comment
The establishment of IVF Companies onto the stock-market may be good in that it generates money for new development and research. More than one player should lead to more efficient service and competitive prices which is good for IVF clients. It may also lead to prices as high as the market could bear and more difficult work practices (eg more ICSI or day 5 transfers and fewer freezings). One concern though is that in Australia, the IVF industry is largely underwritten by Medicare and one thing is for certain, Medicare will not continue to generously fund shareholder funder companies as they did when it was a cottage industry. Look at pathology if you care to look into the future. When funding is limited, the smaller clinics will the ones to suffer.
Anyone care to comment on this.
Title
Autism and PCOS
Summary
This study from an Italian group suggests daughters from hyperandrogenic PCOS clients have an elevated risk from autism and related disorders.
Comment
More recently, another study (see IVFDaily)that elevated testosterone in amniotic fluid is also related to autism. More recently, a review in Hum Reprod failed to find an association between IVF and autism. One wonders though whether the risk to a few PCOS clients is being lost within the IVF population at large. Another study from Sweden also found a very minor link between IVF and autism disorders where their focus was on ICSI and poor sperm quality. These studies looking at an endocrinology origin for some autism links should cause some clinics to discuss inclusion in their risk statements to clients about autism.
Title
Effect of red light on the development and quality of mammalian embryos
Summary
Background monitoring work to support the efficacy of time-lapse embryo culture.
Comment
Probably difficult to perform this with human embryos but it remains an important background observation for those clinics using time-lapse culture systems. Many of the algorithms developed using timing of cleavage rates need to be viewed against the impact of red-light compared to repeated exposure to room light wavelengths and microscopes commonly used for embryo assessment.
Title
Possible choice of viable human blastocysts after vitrification by monitoring morphological changes
Summary
The study asks the question whether time-lapse monitoring is able to identify the viability of shrunken blastocysts after vitrification and thawing.
Comment
Interesting article that addresses one of the issues of blastocyst vitrification- that of the viability of embryos whose cavity has collapsed after warming. They reported only 7% of transfers involved shrunken blastocysts and that their pregnancy rate was still an impressive 40% (given the age of the women was unclear. These embryos exhibited reduced oxygen uptake but a proportion resumed expansion and hatching after 5 hours of extended culture. Data does suggest that more (at least 40%) will be able to expand and hatch (since pregnancies followed). Unsure whether time-lapse added any more information that what may be gained from visual checking. Still it give some confidence that if the shrunken blastocyst as not re-expanded by the time of transfer, the prognosis of pregnancy remain very high.
Title
Influence of interpregnancy interval on birth timing
Summary
IPI- interpregnancy interval- is linked to the likelihood of have a pre-term pregnancy. An IPI of less than 12 months is associated with a 53% chance of <39 term pregnancy.
Comment
Apparently, a short IPI is a known risk factor for preterm birth. This large study confirms these observations. This was more pronounced for negro populations compared to non-negro populations. Unlike fertile populations, IVF populations conceptions are more measured and couples returning for a second pregnancy can be counselled to delay treatment if their IPI is too short. This may be more effective with frozen embryos where maternal age is less critical. It is well established that delaying treatment for women more than 35 years may reduce their chance of conception. However, if a pregnancy has arising from a fresh transfer, couples may well be advised to defer a FET treatment if the IPI is less than 12 months. It would be interesting to know the standard IPI for IVF couples and asking whether the incidence of preterm pregnancies may be linked to a short IPI.
Title
Direct Real-Time Measurement of Intra-Oocyte Nitric Oxide Concentration In Vivo
Summary
This report identify lower NO values with increasing age suggesting increased oxidative stress and the decrease in antioxidant machinery.
Comment
Nitric oxide (NO) is reported to play significant a role in oocyte activation and maturation, implantation, and early embryonic development. Lower NO levels with age suggest increased oxidative stress and the decrease in antioxidant machinery. Previous work, which showed that supplementation with NO delays the oocyte aging process by diminution of oocyte ooplasmic microtubule dynamics (OMD), cortical granule (CG) loss, ZP dissolution timing and improves spindle and chromosomal integrity. While this work was conducted on mice and requires specialised probes, the relationship to ovarian aging and decreased fertilisation rates and embryo viability reminds IVF staff that there may be other reasons for ovarian aging and in mice at least, NO supplementation with NO (mechanism unclear) in part could reverse NO effects on ovarian aging. Interesting concept to treating older women!
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
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