Comment:ESHRE release with many links to summaries of articles from the 2014 ESHRE Meeting. Also a link to a new e-learning module Fertaid is developing to test you IVF knowledge. IF you have a set of multiple choice questions on any area of IVF especially for nurses and non lab staff, FertAid would be interested in seeing them.
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Physical activity before IVF and ICSI cycles in infertile obese women: an observational cohort study
Our results demonstrate that the chances to obtain a pregnancy and a baby are 3-fold higher in obese infertile patients who does physical activity regularly in comparison with those who does not, suggesting that regular physical activity before ART cycles improves the reproductive performance in obese women irrespective to body weight loss.
Children born to women after fertility treatment at greater risk of psychiatric disorders
Children born to women with fertility problems have a higher risk of psychiatric disorders than naturally conceived children. The increase in risk was described as "modest" by researchers from Denmark, but was found to persist throughout childhood and into young adulthood.
Pregnancies following egg donation associated with more than three-fold higher risk of hypertension
With an ever-ageing female patient population, egg donation is an increasingly common treatment in infertility. ESHRE's own annual reports on fertility treatments in Europe show a rise in egg donation cycles from 15,028 in 2007 to 24,517 in 2010 (to 4.05% of all treatments). This proportion is still some way behind the USA, where egg donation now accounts for around 12% of all treatments.
Freeze-storage egg banking for egg donation treatment
The rapid freezing technique of vitrification is set to revolutionise egg donation as a fertility treatment by enabling freeze-storage egg-banking. The cryopreservation of eggs was one of IVF's continuing challenges until the widespread introduction of vitrification: the older slow freezing methods induced the formation of ice crystals, which could cause damage to several structures of the egg. Thus, as demand for egg donation increases as a trea
Most women are aware of oocyte freezing for social reasons
While the majority of younger women are aware of egg freezing as a technique of fertility preservation and consider it an acceptable means of reproductive planning, only one in five would consider it appropriate for them, according to the results of an internet survey performed in the UK and Denmark.
Preconceptional factors in the prediction of fertility and the reproductive lifespan
Now, the Danish study has found that measurements of AMH and AFC were 19% and 16% respectively lower in Pill users than in those not taking the Pill. In addition, ovarian volume was also significantly smaller - by between 29 and 52%, with the greatest reductions seen in the group aged 19-29.9 years.
Children born to women after fertility treatment at greater risk of psychiatric disorders
Children born to women with fertility problems have a higher risk of psychiatric disorders than naturally conceived children, Danish research suggests. The increase in risk was described as 'modest' by researchers, but was found to persist throughout childhood and into young adulthood. Research suggests that 1.9% of all diagnosed psychiatric disorders in Denmark are associated with the mother's infertility.
Men should be allowed to donate sperm up to the age of 45
Men should be allowed to donate sperm up to the age of 45 because IVF success is not determined by the age of the donor, research has found.
A study by Newcastle Fertility at the Centre for Life showed that it was the quality of the sperm that mattered in conception.Currently men can only donate until the age of 40 because previous studies have shown that sperm quality declines with age
A large multicentre trial seems finally to have resolved one of IVF's long-running controversies - whether the outlook for women with a poor IVF record can be improved by routine hysteroscopy performed before further IVF treatment.(1) For the TROPHY study, whose results are reported today at the 30th Annual Meeting of ESHRE in Munich by Dr Tarek El-Toukhy from Guy's and St Thomas's Hospital, London, has now found no significant difference in IVF
No link between fertility drugs and breast, ovarian and uterine cancers
There is "little evidence" that the use of conventional fertility hormones used for ovarian stimulation in the treatment of infertility increases the long-term risk of breast and gynecological cancers, according to the results of a substantial 30-year follow-up study. However, the extended use of clomiphene citrate was associated with a higher risk of breast cancer among women who had used the fertility drug for 12 cycles or more. Gonadotrophins,
The outcome of fertility treatments using donor sperm is dependent on the quality of sperm
Despite emerging evidence of a decline in sperm quality with increasing age, an analysis of every first fertility treatment cycle performed in the UK using sperm donation shows that outcome in terms of live birth is not affected by the age of the sperm donor. Results from the study, said its principal investigator Dr Meenakshi Choudhary, from the Newcastle Fertility Centre at Life, Newcastle upon Tyne, United Kingdom, reaffirm the observation tha
Future reproductive lifespan may be lessened in oral contraceptive users: Lower measures of ovarian reserve
A project in Denmark whose aim is to assess the reliability of preconceptional lifestyle and biological factors as predictors of fertility has found a pronounced effect of the contraceptive pill on markers used to assess 'ovarian reserve,' a predictor of future reproductive lifespan
No link between fertility drugs and breast, ovarian, uterine cancers, study finds
There is 'little evidence' that the use of conventional fertility hormones used for ovarian stimulation in the treatment of infertility increases the long-term risk of breast and gynecological cancers, according to the results of a substantial 30-year follow-up study. The study was a retrospective investigation involving 12,193 women treated for infertility between 1965 and 1988 at five US sites. A total of 9,892 women were successfully followed
Freeze-storage egg banking for egg donation treatment
The rapid freezing technique of vitrification is set to revolutionize egg donation as a fertility treatment by enabling freeze-storage egg-banking. The cryopreservation of eggs was one of IVF's continuing challenges until the widespread introduction of vitrification: the older slow freezing methods induced the formation of ice crystals, which could cause damage to several structures of the egg.
Fertaid Mail - FertAid Interact. [This link may be from a sponsor]
FertAid is developing a new interactive module where items can be listed for discussion, products can be promoted, jobs, etc. It is envisaged the module will be open to all IVF Clinic staff not just embryology.
Innovative Cryo Enterprises LLC [This link may be from a sponsor]
I.C.E. is a research and consulting company that specalizes in the cryopreservation and vitrification of gametes and embryos. Our expertise covers human reproduction, as well as, domestic and non-domestic mammalian species.
University of Sydney Now Owns Westmead IVF Pty Limited [This link may be from a sponsor]
On July 2, the University of Sydney announced its ownership of 100 per cent shares of Westmead IVF Pty Limited, the company which operates the private fertility clinic at Westmead Hospital, of Westmead fertility. The takeover is the university's major initiative in the advancement of fertility research and treatment, the university said in a statement
Reproductive Health Science launches IVF embryo collection kit [This link may be from a sponsor]
Reproductive Health Science (ASX:RHS) has launched its lead product, EmbryoCellect at an international forum for reproductive medicine and embryology in Munich, Germany.
Reproductive Health Science Ltd (ASX:RHS) Launches Pre-Implantation IVF Screening Kit EmbryoCellect(TM) [This link may be from a sponsor]
Commenting from Munich, Dr. Fraser said: "There has been real interest in the EmbryoCellectTM product driven by the increasing awareness and use of Pre-Implantation Genetic Screen (PGS) during the IVF process and the clinical data demonstrating its positive effects on IVF success rates.
Father's ethnic background influences birthweight, study finds
A father's ethnic background can influence a child's birthweight, a new study has found. Current birthweight curves - graphs used to plot how one baby's weight compares to others of the same age - assume that the parents are of Western European descent. That means many babies of an East Asian or South Asian mother may be classified as underweight, when in fact they are "normal" for their ethnic groups. The new study shows the same is true when th
Current Clinical Embryology Quiz -Questions from articles released in June 2014.
A set of questions from articles listed on IVFaily during June 2014. Have a go while it is the development phase. If you have a list of questions for IVF staff, FertAid would be interested in them.
Physical activity before IVF and ICSI cycles in infertile obese women: an observational cohort study
Summary
Given the concerns about female (and male) obesity on their offsprings health, this article suggests that clinics treating obese females could justify a need to enter an exercise programme.
Comment
There is a growing body of evidence to suggest the weight of the female will impact on their sons future health especially their weight. While this study does not address weight per sea, it is interesting that exercise can have such a dramatic effect on a couples chance of a live birth (7% to 24%). Possibly of more importance is the real problem of weight on pregnancy. A clinic that actively limits patients by weight may expect to have a higher pregnancy rate than a clinic that does not limit by weight. Clinics may also benefit on asking obese clients of their exercise level and point out the advantages on delaying treatment and entering an exercise programe.
Title
The outcome of fertility treatments using donor sperm is dependent on the quality of sperm
Summary
Analysis of the UK HFEA database showed that the chance of conception using donor sperm was independent of the donors age.
Comment
Many national rules have arbitrarily imposed an upper age on donors based upon quite mild rises in miscarriage and infertility. However, in this study where the live birth rate (LBR) was partitioned, donor age was independent of outcome. Indeed, the younger donors (<20 years)behaved poorest (the same with younger women). Many of the rules are based upon generalised genetic risk assessments and are conservative in nature. This study suggests that pregnancy rates are very similar between men below and above 40 years of age. With newer assessment tools such as DNA fragmentation tests, samples from men over 40 years of age with normal semen profiles and DNA fragmentation may well give be suitable donors. The only caveat is that couples know the age of the donor before accepting them and the risk for this is in the signed consent form.
Title
Children born to women after fertility treatment at greater risk of psychiatric disorders
Summary
A study from Denmark exploring the fertility experience of the parents of children conceived between 1969 and 2006 and whether the children were hospitalised for a psychiatric disorder.
Comment
5% of all children came from women with a fertility problem and overall these children were 33% more likely to have been hospitalised for a psychiatric disorder. The disorders included schizophrenia and psychoses, affective disorders, anxiety and other neurotic disorders, mental and behavioural syndromes including eating disorders, mental retardation, mental development disorders including autism spectrum disorders, and behavioural and emotional disorders including attention deficit hyperactivity disorder (ADHD). Wow!! even thought the relative risk was small, the study is nevertheless worrisome. The speakers(presented at ESHRE) point out the study cannot discriminate between the clients and the treatment but suggest the former is a more likely source. One wonders if they are related to male infertility, age or some other socio-economic grouping. When this topic is published as it surely will, clinics will need to consider whether to screen at risk clients, include this in the list of risks or just ignore it for the present.
IVF Training - Questions relating to mailout links -
Open Challenge and complete Questions
Question
Type
Options
Obese women who exercise regularly increase their chance of a live birth on their first IVF attempt
1
4
The live birth rate for women is independent of the age of the donor
1
2
Donors younger than 20 years of age have a lower live birth rate then donors aged 20-40 years of age
1
3
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
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Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
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