Comment:Two opinion pieces from CHR web site, Pat Quinns new book on IVF Culture, and some links to news stories on surrogacy that may be of interest. ALSO I provide the link to 2014 Lab Census. FertAid is keen to get a better understanding of the volume used in IVF. Plus a link to a article on PAWP sperm protein and IVF. Worth a look as this may be a new tool to assess semen.
Survey-2014 Laboratory Census
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Multicentre study of the clinical relevance of screening IVF patients for carrier status of the annexin A5 M2 haplotype
In 314 patients (157 couples), 44% of couples (one or both partners), 24% of females, 26% of males and 37% of couples with unexplained infertility were M2 carriers. This high incidence has provoked further urgent studies on specific patient populations and on the value of post embryo-transfer therapy.
Examining Variation in Recombination Levels in the Human Female: A Test of the Production-Line Hypothesis
Thus, our data provide a direct test of the second tenet of the production-line model and suggest that it does not provide a plausible explanation for the human maternal-age effect, meaning that—45 years after its introduction—we can finally conclude that the production-line model is not the basis for the maternal-age effect on trisomy.
Sperm content of postacrosomal WW binding protein is related to fertilization outcomes in patients undergoing assisted reproductive technology
Our clinical data from infertile couples demonstrate significant correlations between sperm PAWP levels and both fertilization rates and normal embryonic development after ICSI. Considering its proposed role in the initiation of oocyte activation, we suggest that PAWP could have potential applications in the diagnosis and treatment of infertility.
Sequential (hFSH + recFSH) vs homogenous (hFSH or recFSH alone) stimulation: clinical and biochemical (cumulus cell gene expression) aspects
Sequential stimulation leads to an E2 per MII oocyte ratio that is much lower than is seen during treatment with the two drugs individually. Although there is a positive tendency in favor of the sequential treatment, there was no significant difference in pregnancy rates, even taking frozen embryos into consideration.
Sterile filtered paraffin oil supports in vitro developmental competence in bovine embryos comparable to co-culture (Archives)
SPO overlaying is superior to WMO and WMO+CC in supporting in vitro development of bovine embryos. The development rates are further enhanced when embryos are cultured in co-culture system overlaid with SPO. Thus, this data suggest that overlaying oil can significantly influence the pre-implantation embryo development in vitro.
There are about 12 million infertile persons in Nigeria, which constitute almost 10 per cent of the total population, the Association for Fertility and Reproductive Health (AFRH), has revealed.
Computer-automated, time-lapse embryo photography may increase success of in-vitro fertilization
Using computer-automated, time-lapse photography of embryos in the laboratory during in-vitro fertilization may improve embryo selection, potentially increasing the chances of pregnancy among women undergoing the procedure, according to new research.
Leading hypothesis for miscarriages, birth defects ruled out
But after counting the actual chromosome crossovers in thousands of eggs, WSU researchers found those of eggs produced early in the fetal stage were no different from those produced later.
'Remote control' contraceptive chip available 'by 2018'
A contraceptive computer chip that can be controlled by remote control has been developed in Massachusetts. The chip is implanted under a woman's skin, releasing a small dose of levonorgestrel, a hormone. This will happen every day for 16 years, but can be stopped at any time by using a wireless remote control
France to recognise children born via surrogates abroad
France will no longer deny citizenship to children born via surrogates to French parents overseas, Minister for Families Laurence Rossignol confirmed, after a decision at the European Court of Human Rights (ECtHR).
In this case, you should start the procedure immediately after Ramadan. This is the ideal route to follow. If, however, you are left with no other choice, then you may follow the procedure and skip the fast while undergoing the treatment. You ought to make up for the fasts thus missed as soon as possible. This should not prevent you from availing yourself of the opportunities for other good deeds you can possibly do in the blessed month.
StemCells, Inc. Appoints Dr. Alan Trounson to Board of Directors
StemCells, Inc. (Nasdaq:STEM) announced today the appointment of Alan Trounson, Ph.D. to its Board of Directors. Dr. Trounson most recently served as President of The California Institute of Regenerative Medicine (CIRM), the largest scientific funding body for stem cell research in the world.
Test 'can boost IVF success by half': Scientists find new way to identify embryos that will implant in the womb.
The presence of high levels of DNA from energy-producing cells in the embryo is a signal that it will fail to implant and produce a pregnancy, according to researchers from Oxford University. They found a threshold, or cut-off point, below which embryos could be guaranteed to implant, and above which some failed to do so.
An unscrupulous surrogacy operation in Mexico has left clients thousands of dollars out of pocket, and dozens of would-be surrogates abandoned, a Foreign Correspondent investigation has revealed.
On the Embryoscope as Marketing Tool: Where CNN Went Wrong
CHR is concerned about the increasing use of the "embryoscope" and similar products from other manufacturers as marketing tools in in vitro fertilization (IVF). Our analysis of published studies so far reveals no outcome benefits from the use of time-lapse photography and closed incubation systems on IVF outcomes. While published data report on identification of significant difference in development speed and other morphological characteristics b
On How the Utilization of Preimplantation Genetic Diagnosis (PGS) Is Viewed in the Medical Literature [OPINION]
CHR is seriously concerned about the uncontrolled and, in our opinion, premature reintroduction of preimplantation genetic screening (PGS) into routine infertility care. We are, furthermore, concerned about what, to us, appears as a biased peer review process at major medical journals within the Ob/Gyn specialty, when the issue of PGS is presented. These biases are, likely, unintended consequences of selecting expert reviewers with either unbalan
Gift transforms University's approach to fertility research and treatment
Westmead IVF has been given to the University as part of a major gift from a foundation established by one of the University's own alumni and staff members, Professor of Obstetrics and Gynaecology, Brian Trudinger. The fertility service was established 30 years ago and Professor Trudinger has been custodian for the past 22 years. It has the express aim of making high quality fertility treatment accessible to all patients at the lowest possible co
Genetic screening could reduce recurrent miscarriages
The presence of a specific genetic variant in the annexin A5 (ANXA5) gene known as the C4/m2 variant or M2 haplotype in either parent has already been implicated in both obstetric complications such as pre-eclampsia, intrauterine fetal growth restriction and death, and in recurrent pregnancy loss (RPL). It is involved in fetal-induced disruption of normal blood clotting in the placenta, thought to interfere with normal implantation of the embryo.
Culture Media, Solutions, and Systems in Human ART By Pat Quinn
This volume describes culture media and solutions used in human ART: how they have been developed for in vitro human pre-implantation embryo development, the function and importance of the various components in media and solutions and how they interact, and how the systems in which these are used can influence outcomes. Chapters discuss inorganic solutes, energy substrates, amino acids, macromolecules, cytokines, growth factors, buffers, pH, osmo
FertAid has released the 2014 laboratory census. The aim is to provide clinics with a sense of what others are doing and how their activity compares to others.
FertAid opens an annual laboratory census on the activities of an IVF laboratory.
Comment
You are invited to complete the activity of your laboratory. When completed, you can review the results both for all replies and for your own country.
Title
Breaking the Fast for IVF Treatment: Allowed?
Summary
This information may be of value to clinics worldwide when dealing with couples of the Moslem faith.
Comment
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Title
France to recognise children born via surrogates abroad
Summary
It would seem to be a positive move to recognise the role surrogacy is playing in the creation of familes
Comment
In many countries, surrogacy is very complex and limiting such as Australia. It is not surprising therefore that couple will go to where their needs can be meet such as India or Eastern Europe. Accepting children conceived in this manner is the first step but the final step is the legal recognition.
Title
Sequential (hFSH + recFSH) vs homogenous (hFSH or recFSH alone) stimulation:
Summary
rFSH and hFSH regimen are compared separately or sequentially but show only marginal difference.
Comment
A sequential stimulation protocol (hFSH + recFSH ) has been compared to homogenous h FSH and rFSH protocol in three group of 30 patients. Clinical results and Cumulus cells (CC cells)gene expression has been analyzed. The sequential treatment leads to a E2 per MII oocyte ratio more physiological and much lower than the other treatment. It leads to better but not significant pregnancy rates, even taking frozen embryos into consideration. hFSH treatments appears to be rather associated with depletion, rather than over-expression of Poly(A) mRNAs: this means that the trophic transfer towards the oocyte has been completed. The CC cells mRNA content in the pregnant patients is depleted when compared to the non pregnant group. The usefulness of CC transcriptome analysis for selecting the best embryos is, at the very least, questionable, as some published statements are rather misleading.
IVF Training - Questions relating to mailout links -
Open Challenge and complete Questions
Question
Type
Options
The greater the proportion of euploidy embryos in a cohort, the better the pregnancy rate is for SET transfers compared to DET transfers.
1
2
What type of oil are used in IVF
2
2
Mineral Oil and paraffin oil are
2
8
Toxicity has been encountered from
2
4
Which is TRUE
2
10
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
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