Comment:I have included a link to a new survey on sperm DNA fragmentation and a forum posting on the same subject. I encourage all IVFDaily recipients to complete the survey and contribute to the forum. Spread the link to members of your own societies. I have also included some links to articles on the cost effectiveness of oocyte cryostorage for fertility preservation and new stem cell work producing primordial oocytes [in mice].
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Giving a whole new meaning to "pregnancy brain," a new study shows that male DNA—likely left over from pregnancy with a male fetus—can persist in a woman's brain throughout her life. Although the biological impact of this foreign DNA is unclear, the study also found that women with more male DNA in their brains were less likely to have suffered from Alzheimer's disease—hinting that the male DNA could help protect the mothers from the disease, the
Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–Like Cells in Mice
We show here that female (XX) embryonic stem cells and induced pluripotent stem cells in mice are induced into primordial germ cell-like cells (PGCLCs), which, when aggregated with female gonadal somatic cells as reconstituted ovaries, undergo X-reactivation, imprint erasure, cyst formation, and exhibit meiotic potential. Upon transplantation under mouse ovarian bursa, PGCLCs in the reconstituted ovaries mature into germinal vesicle-stage oocytes
Want baby mice? Grab a petri dish. After producing normal mouse pups last year using sperm derived from stem cells, a Kyoto University team of researchers has now accomplished the same feat using eggs created the same way. The study may eventually lead to new ways of helping infertile couples conceive.
Expanding reproductive lifespan: a cost-effectiveness study on oocyte freezing
Oocyte freezing is more cost effective compared to IVF, if at least 61% of the women return to collect their oocytes and if one is willing to pay €19 560 extra per additional live birth. Our Markov model shows that, considering all the used assumptions, oocyte freezing provides more value for money than IVF.
Fertility preservation for social indications: a cost-based decision analysis
Neither oocyte cryopreservation nor OTC appear to be cost effective under current conditions for otherwise healthy women planning delayed childbearing. Until alternative fertility strategy success rates rival current ART techniques, the practice of offering oocyte cryopreservation or OTC for social reasons may be premature.
Cost-effective analysis of oocyte cryopreservation: stunning similarities but differences remain
Although we both employed similar decision analysis techniques, striking differences were obtained in the results, with the US-based study of Hirshfeld-Cytron et al. noting that oocyte cryopreservation cost an additional $135 520 per live birth, while the European study of Van Loendersloot et al. noted that if 61% of women utilized their frozen gametes, oocyte cryopreservation was cost effective at an additional $24 600 per live birth.
Optimising vitrification of human oocytes using multiple cryoprotectants and morphological and functional assessment
Oocyte quality was significantly higher using a combination of cryoprotectants than vitrification with individual cryoprotectants. In addition, the quality of vitrified oocyte varied depending on the cryoprotectants and type of combination used. The results of the present study indicate that observations based purely on the morphological appearance of the oocyte to assess the cryosurvival rate are insufficient and sometimes misleading. The outcom
Perifollicular blood flow and pregnancy in superovulated intrauterine insemination (IUI) cycles: An observational comparison of recombinant follicle-s
The group of patients who received urinary gonadotropins (n = 117) for follicular stimulation had a significantly higher incidence of high perifollicular blood flow compared with that of the group who received recombinant FSH (n = 114: 46.3% vs. 22.7%). The overall clinical pregnancy rate in patients stimulated with recombinant FSH was 10.91%, compared with 22.22% in the group stimulated with urinary gonadotropins.
Follicular fluid VEGF levels directly correlate with perifollicular blood flow in normoresponder patients undergoing IVF.
The ability of a given follicle to express VEGF and develop an adequate vascular network may be inter-related in patients under the age of 35. An adequate blood supply may be fundamental important in the regulation of intrafollicular oxygen levels and the determination of oocyte quality.
Mom's Immune System Primed and Ready for Second Baby
Fewer photos aside, sometimes there's an upside to being the second kid: Mom's body may be primed to tolerate you. For many moms, pregnancy gets easier the next time around—and now researchers know part of the reason why. A new study in mice shows that a mother's immune system calls on a special set of cells to protect her growing fetus—and these cells linger long after birth to ease the way for a subsequent pregnancy. The discovery could help re
Mice skin cells turned into eggs, suggesting new fertility treatments
JAPANESE scientists have turned mouse skin cells into eggs that produced baby mice - a technique that, if successfully applied to humans, could someday allow women to stop worrying about the ticking of their biological clocks and perhaps even help couples create "designer babies."
Mom's High Blood Pressure in Pregnancy Could Affect Child's IQ Into Old Age
New research suggests that a mother's high blood pressure during pregnancy may have an effect on her child's thinking skills all the way into old age. The study is published in the October 3, 2012, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Infertility Treatments May Significantly Increase Multiple Sclerosis Activity
Researchers in Argentina report that women with multiple sclerosis (MS) who undergo assisted reproduction technology (ART) infertility treatment are at risk for increased disease activity. Study findings published in Annals of Neurology, a journal of the American Neurological Association and Child Neurology Society, suggest reproductive hormones contribute to regulation of immune responses in autoimmune diseases such as MS.
Surgeons Recreate Eggs in Vitro to Treat Infertility
Regenerative-medicine researchers have moved a promising step closer to helping infertile, premenopausal women produce enough eggs to become pregnant. Surgeons at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine in Winston-Salem, NC, have now reported that they were able to stimulate ovarian cell production using an in vitro rat model, and observed as the cells matured into very early-stage eggs that could possibly be fert
Balancing Fertility and Child Survival in the Developing World
Children in smaller families are only slightly more likely to survive childhood in high mortality environments, according to a new study of mothers and children in sub-Saharan Africa seeking to understand why women, even in the highest fertility populations in world, rarely give birth to more than eight children.
Fear of Treatment Puts Stress On Women Undergoing Fertility Therapy
Fertility treatment has a strong emotional impact on women who want to have children. A study of European countries with the highest number of assisted reproduction cycles identifies which aspects of reproduction treatment contribute to psychological stress.
Sperm DNA Fragmentation SURVEY [This link may be from a sponsor]
Assessment of Sperm DNA Fragmentation by TUNEL, SCSA, halosperm or other appear very popular but is it? Complete the survey to find out just how many clinics are performing this assay. [Tell your fellow scientists to complete this survey!!]
Expanded Halosperm EQA program. [This link may be from a sponsor]
An EQA/Competency schemes for the assessment of sperm DNA fragmentation by the Halospem method. This has been expanded to 12 data sets for 2013 with images form several users. Participants are shown 20+ sets of images from one sample and asked to estimate the number Normal and abnormal sperm ( according to the methodology) and calculate a % DFI
Many clinics perform some type of sperm DNA Fragmentation but how is it used and what method is employed. For instance, does a clinic apply it as a screening test or before each IVF cycle or only after a poor cycle or miscarriage. I am interested in how clinics are applying the methodology, what cut-offs are used for clinic intervention and how do clinic respond to an elevated result. There is a survey to complete to balance this forum. All comme
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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