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Perinatal outcomes associated with assisted reproductive technology: the Massachusetts Outcomes Study of Assisted Reproductive Technologies (MOSART)
Conclusion(s): The use of a population-based comparison group of subfertile births without ART demonstrated significantly higher rates of preterm birth and low birth weight in ART singleton births, but these differences are smaller than differences between ART and fertile births. Further refinement of the measurement of subfertile births and examination of the independent risks of subfertile births is warranted.
Clinical management of infertile men with nonobstructive azoospermia
The clinical management of men with nonobstructive azoospermia (NOA) seeking fertility has been a challenge for andrologists,
urologists, and reproductive medicine specialists alike. This review presents a personal perspective on the clinical management of
NOA, including the lessons learned over 15 years dealing with this male infertility condition. A five-consecutive-step algorithm is
proposed to manage such patients.
ISO/IEC 17025 Standard Application Document for accreditation of testing and calibration facilities [NATA]
This document provides interpretative criteria and recommendations for the application of ISO/IEC 17025 in all fields of testing and calibration for both applicant and accredited facilities.
Giant oocytes in human in vitro fertilization treatments
Conclusions: Our data suggest that the stimulation protocol does not affect the incidence of giant oocytes. Giant oocytes present in cycles with higher number of retrieved oocytes in younger women. The presence of these gametes does not refer to the quality of sibling oocytes and embryos, or the outcome of the treatment.
Distinct localisation of lipids in the ovarian follicular environment
There were no associations between follicular fluid metabolites or oocyte lipid content and clinical outcomes: however, oocyte immaturity correlated with follicular fluid glucose and fatty acid levels, as well as metabolic syndrome. The present study confirms that the human ovarian follicular environment surrounding the oocyte exhibits a unique metabolite profile compared with blood, with distinct localisation of lipids within follicular fluid an
Evolution of childbirth: Wider hips don't make locomotion easier, so why is labor so hard?
A new study found no connection between hip width and efficient locomotion, and suggests that scientists have long approached the problem in the wrong way. "This idea, that pelvic width for birth and pelvic width for locomotion are connected, is deeply ingrained in this discipline," said the first author of the study. "Everyone thinks they know this is true...but it's wrong, and it's wrong for two reasons. First, the way we had modeled the forces
Effects of female increased body mass index on in vitro fertilization cycles outcome
Conclusion: Although overweight and obesity do not compromise ovarian stimulation results whenever adaptation of recombinant FSH doses is made, our data suggest an increased risk of cancellation transfer and miscarriage rate, leading to poorer IVF outcome.
Underlying subfertility may affect ART birth outcomes, study finds
Birth outcomes for babies whose mothers used assisted reproductive technology (ART) are better in some cases, and worse in others, than for subfertile women who did not use ART, according to a first-of-its-kind study.
Perinatal outcomes associated with assisted reproductive technology: the Massachusetts Outcomes Study of Assisted Reproductive Technologies (MOSART)
Summary
Outcomes from ART conceptions are higher than for births from sub-fertility couples and both are poorer compared to fertile births showing that the underlying fertilty issues can influence outcomes
Comment
This new publication from the MOSART study in the USA looked at a number of birth outcomes (preterm birth, low birth weight, small for gestational age [SGA], and perinatal death) and found that ART (all treatments) has a higher perinatal risk for preterm births and SGA than for conceptions to sub-fertile women not involving ART treatment and that both ART and non-ART/sub-fertile conceptions had a higher risk of perinatal risk than for conceptions to fertile women (couples). The authors inferred that part of the ART risk may be attributed to sub-fertile women rather than the treatment. Preterm deaths were less for ART twin conceptions than for fertile women possibly due to increased clinical care but this was not the main aim of the study. This observation is a common theme in many ART birth outcome studies - that is that there are intrinsic and treatment risks and both contribute to adverse outcomes. The primary note that can be drawn form this work is that couples undertaking ART should have this information explained as part of their informed consent. A problem is that IVF is changing rapidly. Most changes can only lead to a better perinatal risk for ART but can do nothing to reduce the sub-fertility risk. Single embryo transfers, FET conceptions, managed stimulation or low FSH dose regimens and social infertility such as the treatment of single (fertile) women by IVF are changes that should lower the ART risk. It is unclear whether improved embryo selection or day 5 transfers will lower the risk even further. It may take another 10+ years to gather sufficient data to show this. In summary, the IVF industry should accept there is are birth risks attached to ART treatment that while significant can only reduced over time and rather than stopping treatment need to be addressed by improving cycle management and informed consent.
Title
Wider hips don't make locomotion easier, so why is labor so hard?
Summary
First up I am not an pediatrician or Obstetrician but I thought this article was enlightening. I like studies that overturn existing viewpoints.
Comment
The article by Anna G. Warrener,et. al has examined if wider hips mean slower movement and found that it did not. In other words, the argument that evolution has always been a compromise between the width of the pelvis and the size of the baby where the width of the pelvis was limited to walking/running speed. The authors project that the real problem is not the width of the hips but the size of the baby. Historically, this relationship may have been in balance but in more recent times, diet has not been limiting and the size of the baby has been growing disproportionately to hip size. Which leads one to speculate that the current size of babies is atypical and by extension, the normal range of babies may not reflect the evolutionary profile. Could small for gestational age now reflect a normal range in our historical past. Does the current diet or available energy commit more women to surgical deliveries. Interesting thought bubble!!
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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