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Paternally contributed centrioles exhibit exceptional persistence in C. elegans embryos
The two gametes make different contributions to the zygote at fertilization. Although both gametes contribute genetic material, in most animal species the oocyte donates the bulk of cytoplasmic constituents and cellular organelles, including mitochondria, whereas the sperm donates two centrioles
Association Between Assisted Reproductive Technology Conception and Autism in California, 1997–2007
Results. In the full population, the incidence of diagnosed autism was twice as high for ART as non-ART births. The association was diminished by excluding mothers unlikely to use ART: adjustment for demographic and adverse prenatal and perinatal outcomes reduced the association substantially, although statistical significance persisted for mothers aged 20 to 34 years.
Association of Biomedical Andrologists – Laboratory Andrology Guidelines for Good Practice Version 3 – 2012.
The following guidelines have been developed by the ABA to be used in andrology laboratories. They are aimed at providing guidance on current best practice for both diagnostic and treatment-associated andrology and should be seen as the discipline specific supplementary to the Clinical Pathology Accreditation (UK) Ltd (CPA) accreditation ‘Standards for Medical Laboratory’ and the HFEA Code of Practice for licensed fertility centres (HFEA, 2010).
Association of Clinical Embryologists – Guidelines on Good Practice in Clinical Embryology Laboratories 2012.
The ACE Guidelines on Good Laboratory Practice were initially drawn up in 1996 and were considered as the minimal requirements for any laboratory offering assisted reproductive technology in the UK. However, since that time, the field of assisted reproduction has grown rapidly in the UK both in terms of training, regulations and technological advances.
A plea for caution and more research in the ‘experimental’ use of ionophores in ICSI
It should be self-evident that use of this methodology for the rare cases of total fertilization failure requires clearly written protocols and informed consent documents that describe the potential benefit and possible negative consequences of activation, as they are known or suggested at the present time.
Fertaids and IVF Training new monthly journal club. This month is reviews the free article by Jonathan van Blerkom, Jacques Cohen, Martin Johnson on A plea for caution and more research in the ‘experimental’ use of ionophores in ICSI in RBMonline
Increased Frequency of Aneuploidy in Long-Lived Spermatozoa
This study revealed the novel finding that the frequency of aneuploid spermatozoa with fertilization capability significantly increased compared to that of euploid spermatozoa over 3 days, suggesting that aneuploid spermatozoa can survive longer than euploid spermatozoa and have a greater chance of fertilizing oocytes.
Fewer multiple births could reduce autism risk in ART children
The incidence of diagnosed autism was twice as high for assisted reproductive technology (ART) as non-ART births among the nearly 6 million children in a recent study, born in California from 1997 through 2007. However, much of the association between ART and autism was explained by age and education of the mother as well as adverse perinatal outcomes, especially multiple births.
Beyond genes: Are centrioles carriers of biological information?
Scientists have discover that certain cell structures, the centrioles, could act as information carriers throughout cell generations. The discovery raises the possibility that transmission of biological information could involve more than just genes. Centrioles may actually be carriers of information, which holds profound implications for biology and disease treatment.
IVFeLearning CPD Module: Understanding Sperm Morphology Part 1.
The definition of what is a normal sperm has changed in recent times from one looking at a mans fertility to the diagnosis of male infertility. In this module, Roelof Mankveld explores the history of how the definition of sperm morphology has morphed from `normal` to `abnormal`.
In all accreditation processes, the first requirement is the definitions and processes involved with qualifications of key personnel and the management of clinic or laboratory staff. ISO 15189 lists 9 key points that need to be addressed.
Fewer multiple births could reduce autism risk in ART children
Summary
In a large and quite worrying study, the likelihood of an IVF child developing autism is TWICE that of non IVF children and linked to multiple pregnancy.
Comment
This is a worrisome study in that is it derived from a large cross-linked analysis showing something that may other wise have been missed. Autism is a post delivery issue that may well pass unnoticed to normal reviews. From what I understand from the report, single embryo transfers were not related to autism but multiple pregnancy and birth complications were. While such studies need to be confirmed in many other reviews, surely this alone is an argument for not risking multiple pregnancy by transferring more than one embryo. This may lead to more day 5 transfers and FETs but may result in lower pregnancy rates. This may be better than the thought of causing even one case of autism. One does not have to think very hard on this issue to realise that continued multiple embryo transfers place the clinic to future risk of litigation unless the risks are clearly explained to clients.
Title
Beyond genes: Are centrioles carriers of biological information?
Summary
EPFL scientists discover that certain cell structures, the centrioles, could act as information carriers throughout cell generations.
Comment
Quote `In summary, our data demonstrate that paternally contributed centriolar components exhibit remarkable persistence in the embryo. Given that b-tubulin, SAS-4 and SAS-6 are core structural components of centrioles, the entire centriole organelle could be considered to exhibit exceptional persistence across many cell cycles. It will be of interest to determine whether such exceptional persistence can be extended to centrioles of somatic cells in nematodes and also to other systems. Macromolecular complexes other than centrioles exhibit long-term persistence. This is the case for example of nucleopores in terminally differentiated cells, where cumulative damages in some nucleopore constituents have been linked to cell aging, both in C. elegans and rats10. Similarly, cumulative damages of centriolar components exhibiting long-term persistence could eventually be detrimental to function and even contribute to disease. Our findings also raise the intriguing possibility that centrioles may act as information carriers across several cell cycles, for instance through posttranslational modifications of the persistent centriolar proteins reported here. Conceivably, this could also allow the paternal gamete to donate dedicated information to the zygote, in a manner that is conceptually analogous and reciprocal to the contribution of maternally provided mitochondria.` end quote
IVF Training - Questions relating to mailout links -
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After no pregnancy, failed fertilisation may be considered the next biggest fear of couples undertaking IVF.
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IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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Irvine Scientific
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