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Teratozoospermia: spotlight on the main genetic actors in the human
The studies described here provide valuable information regarding the genetic and molecular defects causing infertility, to improve our understanding of the physiopathology of teratozoospermia while giving a detailed characterization of specific features of spermatogenesis. Furthermore, these findings have a significant influence on the diagnostic strategy for teratozoospermic patients allowing the clinician to provide the patient with informed g
Stunted tail sperm defect: An Ultrastructural Study Of An Atypical Case (2006)
Scanning electron microscopy revealed sperm heads with intact nuclei and acrosomal regions. To our surprise, the 12% of the stunted tails evaluated had biflagellate arrangement while the other ones had uniflagellate tail.
Tracking nutrient transfer at the human maternofetal interface from 4 weeks to term
We deduce that decidual cell glycogen is broken down for transport into the placenta where the products may be reassembled into glycogen or used for metabolic processes. First trimester histiotrophe is internalised by syncytiotrophoblast, then broken down in apical vacuoles containing lysosomal markers. This process declines after haemotrophic nutrition commences
Male fertility is declining in developed countries, as well as in developing countries. External factors linked to lifestyle, such as eating disorders, negatively affect spermatogenesis, both at central and gonadal levels. The overconsumption of high-energy diets (HED) alters the functioning of the male reproductive axis and consequently affects the testicular physiology, disrupting its metabolism and bioenergetic capacity. Testicular metabolism
Relationship between physical occupational exposures and health on semen quality: data from the Longitudinal Investigation of Fertility and the Enviro
A negative relationship among occupational exertion, hypertension, and the number of medications with semen quality was identified. As these are potentially modifiable factors, further research should determine whether treatment or cessation may improve male fecundity.
Predictors of In Vitro Fertilization Outcomes in Women with Highest Follicle-Stimulating Hormone Levels ≥:12 IU/L: A Prospective Cohort Study
Our findings suggest that it would be beneficial for women with increased FSH levels to attempt a cycle of IVF. Results of ovarian stimulation, especially embryo quantity appear to be the best predictors of IVF outcomes and those can only be obtained from a cycle of IVF. Therefore, increased basal FSH levels should not discourage women from attempting a cycle of IVF.
Digital Microfluidic Dynamic Culture of Mammalian Embryos on an Electrowetting on Dielectric (EWOD) Chip
Our results show that the dynamic culture powered with EWOD can manipulate a single droplet containing one mouse embryo and culture to the blastocyst stage. The rate of embryo cleavage to a hatching blastocyst with a dynamic culture is significantly greater than that with a traditional static culture (p<0.05). The EWOD chip enhances the culture of mouse embryos in a dynamic environment. To test the reproductive outcome of the embryos collected fr
Adherence compounds in embryo transfer media for assisted reproductive technologies [Cochrane review]
Analysis of the 16 studies that were identified using functional concentrations of HA showed an increase in the chances of pregnancy and live birth (450 vs 367 per 1000) but also an increase in the chance of the more risky outcome of multiple pregnancy (282 vs 175 per 1000). This increase in multiple pregnancy rate may be the result of improved pregnancy outcomes due to the addition of the adherence compound and the policy of transferring more th
Beijing Olympics 'natural study' links pollution to lower birth weight
Exposure to high levels of pollution can have a significant impact on fetal growth and development, researchers conclude. Their study found that women who were pregnant during the 2008 Beijing Olympics, when pollution levels were reduced by the Chinese government, gave birth to children with higher birth weights compared to those who were pregnant before and after the games.
US 'will not fund research for modifying embryo DNA'
Modifying the DNA of embryos is a "line that should not be crossed", a leading figure in US research says. Dr Francis Collins, National Institutes of Health director, was responding to reports that the first embryos had been modified in China. He argued there were "serious and unquantifiable safety issues", big ethical questions and no compelling medical reason to do it. He said the NIH would not fund such research in the US
Womb milk nourishes human embryo during first weeks of pregnancy (New scientist).
Call it the milk of life – not breast milk, but womb milk. For the first 11 weeks of pregnancy, before the mother's nutrient-rich blood supply is plumbed in, all the materials and energy for building a baby are supplied by secretions from glands in the uterus lining.
IVFeLearning CPD Module: ACE consensus meeting report: Culture systems
ACE held a meeting in 2014 to review the current status of IVF Culture systems. A consensus report of that meeting is available on-line and is the basis for this CPD module. The report is must reading for all clinical embryologists. The module summaries the discussion on the current status of IVF Culture media.
IVFeLearning CPD Module: Understanding Sperm Morphology Part 1.
The definition of what is a normal sperm has changed in recent times from one looking at a mans fertility to the diagnosis of male infertility. In this module, Roelof Mankveld explores the history of how the definition of sperm morphology has morphed from `normal` to `abnormal`.
In all accreditation processes, the first requirement is the definitions and processes involved with qualifications of key personnel and the management of clinic or laboratory staff. ISO 15189 lists 9 key points that need to be addressed.
Semen Quality and chronic health situations, occupation and medical history
Summary
Conclusion(s): A negative relationship among occupational exertion, hypertension, and the number of medications with semen quality was identified. As these are potentially modifiable factors, further
Comment
[quote] - Result(s): In all, complete data were available for 456 men, with a mean age of 31.8 years. Work-related heavy exertion was consistently associated with lower semen concentration and total sperm count. Thirteen percent of men who reported heavy exertion displayed oligospermia, compared with 6% who did not report workplace exertion. Shift work, night work, vibration, noise, heat, and prolonged sitting were not associated with semen quality. Men with high blood pressure had significantly lower strict morphology scores compared with normotensive men (17% vs. 21%). In contrast, hyperlipidemia, diabetes, and composite of total comorbidities were not associated with semen quality. The number of medications a man was taking as a proxy of health status was associated with semen quality. There was a negative association between number of medications and sperm count. [end quote]
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
New Developments at FertAid during
February, 2026 and February, 2026
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A range of online Quality Assurance Modules
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KPI Benchmarking
New to FertAid. This modules allows ANONYMOUS monthly KPI data entry, management of warning and action limits and anonymous comparisons with country and defined KPI sub-groups
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