Comment:This weeks IVFDaily newsletter contains links to a number of relevant articles on pregnancy loss and diagnosis and management from the latest Fertility & Sterility journal. Plus an interesting BBC story on women in science, links to articles on diet and ovulation and a detailed review on growth factors ad follicle recruitment and development. Enjoy.
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Micronutrients intake is associated with improved sperm DNA quality in older men
Men with higher dietary and supplement intake of certain micronutrients may produce sperm with less DNA damage, especially among older men. This raises the broader question of how lifestyle factors, including higher intakes of antioxidants and micronutrients, might protect somatic as well as germ cells against age-associated genomic damage.
Evaluation and treatment of recurrent pregnancy loss: a committee opinion
The majority of miscarriages are sporadic and most result from genetic causes that are greatly influenced by maternal age. Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies, and up to 50% of cases of RPL will not have a clearly defined aetiology.
Interpreting human follicular recruitment and antimüllerian hormone (AMH) concentrations throughout life
The changes in the relationships between circulating antimüllerian hormone, the size of the primordial follicle pool, and follicular recruitment before and through the reproductive years have now been clarified, and show dynamic changes through sexual development. The constant relationship between the number of follicles and circulating antimüllerian hormone exists only after the age of 25 years, implying that the association between follicular r
Ectopic pregnancy: how the diagnostic and therapeutic management has changed
Nowadays ectopic pregnancy often can be diagnosed before the woman’s condition has deteriorated, which has altered the former clinical picture of a life-threatening disease into a more benign condition. This review describes the historical developments in the diagnostic and therapeutic management of ectopic pregnancy leading up to current clinical practice. The first attempts to diagnose ectopic pregnancy originate from the beginning of the 20th
Early pregnancy failure: beware of the pitfalls of modern management
Over-interpretation of a single ultrasound, misunderstanding of the utility of serial hCG values, and inappropriate use of methotrexate can result in iatrogenic complications. Modern management has successfully improved the diagnosis of ectopic pregnancy before rupture: it should now also focus on ensuring that an intrauterine pregnancy is not interrupted as a result of diagnosis and treatment. This article reviews some of the pitfalls of the mo
When is a pregnancy nonviable and what criteria should be used to define miscarriage?
These new criteria state miscarriage be considered only when: an empty gestation sac has an MSD of ≥::25 mm (with no obvious yolk sac), or embryonic crown rump length ≥::7 mm (the latter without evidence of fetal heart activity). If in doubt, repeating scans at an interval is emphasized. It is axiomatic that decisions about embryonic viability must not be open to doubt. So it is surprising how little evidence exists to support previous
We introduced a novel soluble sperm factor for egg activation, sperm-specific citrate synthase, into polyspermic newt eggs to cause Ca2+ waves. Citrate synthase may perform dual functions: as an enzyme in mitochondria and as a Ca2+-inducing factor in egg cytoplasm. We also discuss the close relationship between the mode of fertilization and the Ca2+ rise at egg activation and consider changes in this process through evolution in vertebrates.
Is there a need to definitively diagnose the location of a pregnancy of unknown location? The case for 'no'
However, the majority of women with a PUL at follow-up will either have an intra-uterine pregnancy or a spontaneously resolving PUL, and therefore represent low-risk PULs. Most of these low-risk PULs do not need intervention and expectant management has been shown to be safe and not associated with adverse outcomes.
Do you need to definitively diagnose the location of a pregnancy of unknown location? The case for “yes”
We advocate use of uterine curettage in all cases of nonviable PUL because it limits exposure to a chemotherapeutic agent to only those who need it and it allows for the most accurate information for counseling the patient on prognosis of future pregnancies.
What serial hCG can tell you, and cannot tell you, about an early pregnancy
The serial measurement of serum hCG concentrations is an important clinical tool used to differentiate normal from abnormal pregnancies. At hCG values below which ultrasonography can be diagnostic, the comparison of a patient's hCG dynamics to those of established expected curves of rise or fall can aid the clinician in determining when to follow expectantly and when to intervene. Still, this method has some limitations and should never supersede
Effects of Gastric Bypass Surgery on Female Reproductive Function
Conclusions: Ovulation persists despite morbid obesity and the changes from bypass surgery. Reproductive function after surgery is characterized by a shortened follicular phase and improved female sexual function.
The ovary: basic biology and clinical implications - Review Series
As we discuss here, mutant mouse models and clinical evidence indicate that some of the most powerful intra-ovarian regulators of follicular development include the TGF-β::/SMAD, WNT/FZD/β::-catenin, and RAS/ERK1/2 signaling pathways and the FOXO/FOXL2 transcription factors.
Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration
Kisspeptin administration restored gonadotropin secretion and ovarian cyclicity, suggesting that kisspeptin neurons play a major role in hyperprolactinemic anovulation. Our studies indicate that administration of kisspeptin may serve as an alternative therapeutic approach to restore the fertility of hyperprolactinemic women who are resistant or intolerant to dopamine agonists.
Weight Loss Does Not Improve Fertility, but Does Improve Sexual Function, Research Finds
Losing weight does not necessarily lead to improved fertility in women, but it can improve sexual function, according to Penn State College of Medicine researchers.
Men's Views of Abortion Depend More On Social Class and Circumstances Than On Fixed Beliefs, Interviews Reveal
A study of unmarried men living with female partners found that most would prefer to have input on decisions about terminating an unexpected pregnancy, and most men said their own views would depend more on personal circumstances than any religious or political stand.
Ada Lovelace: Challenging women's status in science
Tuesday 16 October marks Ada Lovelace day, an annual event designed to raise the profile of female scientists, technologists, engineers and mathematicians. Ada Lovelace worked with inventor Charles Babbage on plans for an "analytical engine" in the 1800s, now widely regarded as the world's first computer model - making Ms Lovelace the first computer programmer.
Starvation Hormone Markedly Extends Mouse Life Span, Without Need for Calorie Restriction
A study by UT Southwestern Medical Center researchers finds that a starvation hormone markedly extends life span in mice without the need for calorie restriction. [BUT, the females were infertile!!!!!]. The hormone fibroblast growth factor-21 (FGF21) produced by the liver during starvation. {wonder if it influences sex ratios ??ed}
Infertility: How Can Ovulation Function Be Restored?
It is well known that breast feeding increases the secretion of the prolactin hormone and inhibits ovulation in women. This prevents the onset of a new pregnancy too soon, and so breast feeding was used in the past as a method of contraception. In addition to this physiological condition, there are many other pathological conditions in which the production of prolactin is increased. One of the most frequent is the existence of tumours that induc
Sperm DNA Fragmentation SURVEY [This link may be from a sponsor]
Assessment of Sperm DNA Fragmentation by TUNEL, SCSA, halosperm or other appear very popular but is it? Complete the survey to find out just how many clinics are performing this assay. [Tell your fellow scientists to complete this survey!!]
Expanded Halosperm EQA program. [This link may be from a sponsor]
An EQA/Competency schemes for the assessment of sperm DNA fragmentation by the Halospem method. This has been expanded to 12 data sets for 2013 with images form several users. Participants are shown 20+ sets of images from one sample and asked to estimate the number Normal and abnormal sperm ( according to the methodology) and calculate a % DFI
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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