Comment:First for 2016 after a long time-out. Some of these links may be a bit out of date. Ziki is the new Ebola. More on that next mailout.
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Embryo quality is the main factor affecting cumulative live birth rate after elective single embryo transfer in fresh stimulation cycles
The cumulative live birth rate in this age group varies from 40% to 64% and is dependent on the quality of embryos. Women with three or more top embryos have good chance of having more than one child per ovum pick-up without elevated risk of multiple pregnancies.
A prospective randomized controlled trial investigating the effect of artificial shrinkage (collapse) on the implantation potential of vitrified blast
Although no significant higher implantation rate was found after collapse, the better survival and post-warm embryo quality convinced us to recognize a clinical benefit of artificial shrinkage and to implement it in routine vitrification practice.
Unpacking the mysteries of sperm DNA fragmentation. Ten frequently asked questions
Although it has been thirty years since publication of one of the most influential papers on the value of assessing sperm DNA damage, andrologists have yet to reach a general consensus about how to apply this seminal parameter to improve or predict reproductive outcomes
Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Preliminary Report
These data showed the persistence of Ebola virus RNA in semen and declining persistence with increasing months since the onset of EVD. We do not yet have data on the extent to which positivity on RT-PCR is associated with virus infectivity. Although cases of suspected sexual transmission of Ebola have been reported, they are rare: hence the risk of sexual transmission of the Ebola virus is being investigated. (Funded by the World Health Organizat
Molecular Evidence of Sexual Transmission of Ebola Virus
A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distin
IVF industry criticised for misleading claims, aggressive marketing
Insiders in the IVF industry have criticised clinics for using misleading claims and aggressive marketing in the increasingly cut-throat, multi-million dollar sector.
Taking antidepressants during pregnancy increases risk of autism by 87 percent
Using antidepressants during pregnancy greatly increases the risk of autism, researchers have discovered. The findings are hugely important as six to ten percent of pregnant women are currently being treated for depression with antidepressants.
Ebola virus lives on in semen months after recovery, new research finds
A new study of male Ebola survivors has revealed the virus lives on in semen and can be transmitted to sexual partners, months after the sufferer appears to have staged a full recovery. The report published in the New England Journal of Medicine found two-thirds of men had Ebola in their semen after six months, and a quarter after nine months.
In the animal world, if several males mate with the same female, their sperm compete to fertilize her limited supply of eggs. Longer sperm often seem to have a competitive advantage. However, a study now reveals that the size of the animals also matters. The larger the animal, the more important the number of sperm is relative to sperm length. That’s why elephants have smaller sperm than mice.
Conceiving and raising one child is demanding enough – yet historical reports suggest that one woman bore 69. Are they true? And will modern medicine push the limit even further?
Test tube foals that could help ensure rare breed survival
The recent birth of two test tube foals in the UK, as part of a collaborative project conducted by leading fertility experts, could help benefit rare breed conservation and horses with fertility problems.The births mark the successful completion of a three-year program, the aim of which was to establish and offer advanced breeding methods that are not routinely available in the UK.
Stressed dads affect offspring brain development through sperm microRNA
Researchers have shown at the molecular level how experiencing stress changes a male mouse's sperm in such a way that it affects his offspring's response to stress. This change is imparted epigenetically, or through a means other than the DNA code, by molecules called microRNAs, or miRs.
Tony Wyss-Coray studies the impact of aging on the human body and brain. In this eye-opening talk, he shares new research from his Stanford lab and other teams which shows that a solution for some of the less great aspects of old age might actually lie within us all.
CCE is the official journal of SIERR (Italian Society of Embryology, Reproduction and Research). It is an online open acccess journal that publishes original articles, mini reviews, case reports and videos on biology of reproduction and clinical embryology regarding human and animal models.
In this eye-opening talk, he shares new research from his Stanford lab and other teams which shows that a solution for some of the less great aspects of old age might actually lie within us all.
Comment
This TedX talk is short on statistics but listening to it made me wonder if there may also be an effect on fertility or on oocyte quality.
Title
Cumulative Pregnancy Rate related to the number of good quality embryos.
Summary
Using a cumulative pregnancy model (ET+FET), one can anticipate the likelihood of a live birth based purely on the number of good quality embryos.
Comment
RESULTS [from abstfact] In the fresh cycles, the live birth rate was 29.2% and the cumulative live birth rate was 51.3%, with a twin rate of 3.4%. In the multivariate analysis, having two (odds ratio (OR) 1.73- 95% confidence interval (CI) 1.12–2.67) or 3 or more top embryos (OR 2.66- 95% CI 1.79–3.95) was associated with higher odds for live birth after fresh and frozen embryo cycles. Age, body mass index, duration of infertility, diagnosis or total gonadotropin dose were not associated with the cumulative live birth rate. In cycles with one top embryo, the cumulative live birth rate was 40.2%, whereas it was 64.1% in those with at least three top embryos. Of women who had a live birth in the fresh cycle, 20.4% had more than one child after all frozen embryo transfers. Among women with three or more top embryos after ovum pick-up, 16.1% gave birth to more than one child.
Title
Collapse of the blastocoel prior to vitrifiction (artificial shrinkage)
Summary
Laser Collapse of the blastocoel produced better post warming embryo quality and better but not significantly better implantation rates
Comment
The discussion about artificial shrinkage of the blastocoel prior to vitrification has been the subject of some embryomail dialogue recently. This good paper clearly shows collapse is not detrimental and actually most likely to produce better post warming embryo quality. In this study the difference in implantation rates were not significantly higher (38% vs 26%) but they were moving in that direction and a future study with higher numbers may well demonstrate significance. It would seem further studies are needed to quickly confirm this trend allowing the widespread use of artificial shrinkage as routine in blastocyst vitrification, It would be a shame if many good quality blastocysts potential was impaired because of the failure of embryologists to move to make this a standard procedure.
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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