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Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos [2014 article]
Telomeres consist of a repeated TTAGGG DNA sequence, which typically extends over several thousand base pairs and serves to cap the ends of each chromosome, stabilizing them and protecting against degradation. It has long been appreciated that telomere length declines with age. This phenomenon is traditionally explained by a failure to replicate sequences at the very end of the chromosome during S-phase of each cell cycle, causing telomeres to pr
Maternal physical and sedentary activities in relation to reproductive outcomes following IVF
Of the specific physical activities, only greater time spent in aerobics, rowing, and on the ski or stair machine was associated with higher probability of live birth. Time spent in total and specific sedentary activities were not associated with clinical outcomes of IVF. Physical activity is unlikely to have a deleterious effect on IVF success and certain forms of vigorous activity may be beneficial.
Effectiveness of ovarian age as the background risk for aneuploidy screening in an unselected pregnant population
A non-significant trend was shown for AMH-derived age for both an increased area under the curve (0.986 versus 0.979) and an increased detection rate (from 83% to 100%) for a 1/250 risk threshold. For a 3% false-positive rate, a non-significant trend for increased detection with the use of both AMH- and AFC-derived ovarian ages was observed (from 67% to 83%). These results indicate that, although ovarian derived ages seem to potentially reflect a
Higher β::-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers
Despite no significant difference in the average period of gestation (38 weeks 5 days for both groups), the mean birthweight of infants born following FET was significantly heavier by 161 ::g (3370 ::g versus 3209 ::g: P < 0.001). Furthermore, more infants exceeded 4000 ::g (P < 0.001) for FET although there was no significant difference for the macrosomic category (≥::4500 ::g). We concluded that FET programme embry
Guidelines for risk reduction when handling gametes from infectious patients seeking assisted reproductive technologies
The serostatus of each patient is the key that informs appropriate treatments. This guidance document describes protocols for handling gametes from seroconcordant and serodiscordant couples with infectious disease. With minor modifications, infectious patients with stable disease status and undetectable or low viral load can be accommodated in the IVF laboratory.
Application of failure mode and effect analysis in an assisted reproduction technology laboratory
The maximum reduction in risk, with RPN reduced from 25 to 5, was mostly related to the introduction of witnessing. The critical failure modes in sample processing were improved by 50% in the RPN by focusing on staff training. Three indicators of FMEA success, based on technical skill, competence and traceability, have been evaluated after FMEA implementation. Witnessing by a second human operator should be introduced in the laboratory ....
Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality
. For a subset of 51 of the 73 sperm samples used for fertilization, IVF outcomes were known. A total of 17.6% of these samples had atypical STLs. None of these samples produced an ongoing pregnancy. In contrast, the pregnancy rate for samples that had STLs in the normal range was 35.7% (P = 0.044). In conclusion, STL has potential as a fast and inexpensive form of sperm quality assessment.
Investigating the mechanical properties of zona pellucida of whole human oocytes by atomic force spectroscopy
An indirect analysis with IVF outcome indicates that the ZP outer layer of analysed HOs donated by women who achieved pregnancy is stiffer than that of HOs from women with negative outcome. Our findings suggest that mechanical properties can represent important oocyte quality indicators that may be exploited for the design of innovative ICSI dedicated cell sorters.
The VitriFit Open System Vitrification Carrier by Thomas Flarup Sorensen, ORIGIO
Presentation by Thomas Flarup Sorensen given on the CooperSurgical stand at ESHRE 2016 in Finland, 3-6th July, covering open system vitrification and the launch of ORIGIO's new product, VitriFit.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
New Developments at FertAid during
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