Comment:A few links to X Chromosome Inactivation, Use of spermatogonia stem cells after chemotherapy (in monkeys). Use IVF Daily to post your new positions. Just post a PDF to office@fertaid.com
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Allogeneic transplant led to donor-recipient chimerism in sperm from 2/6 adult recipients. Ejaculated sperm from one recipient transplanted with allogeneic donor SSCs were injected into 85 rhesus oocytes via intracytoplasmic sperm injection. Eighty-one oocytes were fertilized, producing embryos ranging from four-cell to blastocyst with donor paternal origin confirmed in 7/81 embryos. This demonstration of functional donor spermatogenesis followin
X Chromosome Inactivation Is Initiated in Human Preimplantation Embryos
These findings indicate that XCI is initiated in female human preimplantation-stage embryos and suggest that preimplantation dosage compensation is evolutionarily conserved in placental mammals. [Free text in AJHG]
X Chromosome Inactivation Is Initiated in Human Preimplantation Embryos
XIST RNA accumulates at the morula and blastocyst stages and is associated with transcriptional silencing of the XIST-coated chromosomal region. These findings indicate that XCI is initiated in female human preimplantation-stage embryos and suggest that preimplantation dosage compensation is evolutionarily conserved in placental mammals.
AZFc Deletions and Spermatogenic Failure: A Population-Based Survey of 20,000 Y Chromosomes
We conclude that a single rare variant of major effect (the b2/b4 deletion) and a single common variant of modest effect (the gr/gr deletion) are largely responsible for the AZFc region’s contribution to SSF in the population.
NATA Medical Testing - Classes of test - see ART 10.95
Accreditation in the field of Medical Testing is described by classes and sub-classes of test. These classes and sub-classes are fixed descriptors, free text being used to qualify or amplify terms as necessary. Where the scope of testing of a laboratory cannot be adequately described by existing
descriptors, the Medical Testing Accreditation Advisory Committee may from time to time establish new classes and/or sub-classes of test. Notification
Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest
The inactivation of p53 improved the developmental outcome of Sirt3-knockdown embryos, indicating that the ROS-p53 pathway was responsible for the developmental defects. These results indicate that Sirt3 plays a protective role in preimplantation embryos against stress conditions during in vitro fertilization and culture.
Boys left infertile by childhood cancer treatment may one day be able to produce healthy sperm by using stored stem cells, monkey research suggests.
Chemotherapy and radiotherapy can kill tumours and the cells which make sperm. A study, published in the journal Cell Stem Cell, extracted sperm-producing stem cells before cancer treatment and later placed them back into the monkey.
In vitro fertilization linked to increase risk for birth defects
NEW ORLEANS – In vitro fertilization (IVF) may significantly increase the risk of birth defects, particularly those of the eye, heart, reproductive organs and urinary systems, according to new research presented Saturday, Oct. 20, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in New Orleans.
In Vitro Fertilization Linked to Increase Risk for Birth Defects
In vitro fertilization (IVF) may significantly increase the risk of birth defects, particularly those of the eye, heart, reproductive organs and urinary systems, according to new research presented on Oct. 20, at the American Academy of Pediatrics (AAP) National Conference and Exhibition in New Orleans.
Sirt3 Helps Protect Preimplantation Mouse Embryos Against Stress Conditions During in Vitro Fertilization
.. the protein Sirt3 helps protect preimplantation mouse embryos against stress conditions during in vitro fertilization and culture. Of potential clinical significance, the negative effects of Sirt3 inactivation on mouse embryos could be overcome by culture in the presence of an antioxidant or in low oxygen conditions.
Genetic Causes of a Male Infertility Disorder Revealed
Severe spermatogenic failure (SSF) is a genetic condition that causes low sperm count and infertility. New insights into the genetic alterations that cause this disorder and their prevalence in populations of men around the world are provided by a study published by Cell Press in the American Journal of Human Genetics on October 25. The findings reveal which alterations are the greatest risk factors for the disease, and they could be immediately
The Supreme Court has overturned a decision allowing a convicted sex offender access to IVF treatment. A couple known only as ABY and ABZ applied to take part in IVF treatment.
AN increasing number of women are having children later in life, with the number of women falling pregnant in their 40s nearly doubling in the past decade.New figures from the Australian Bureau of Statistics show Australian women continue to delay motherhood. A record number of 12,805 babies were born to mothers over 40 last year, compared with 7100 in 2001.
US scientists say a human and animal trial of a controversial new IVF treatment has yielded promising results. The findings in Nature magazine show healthy-looking embryos can be created from a mix of three adult donors.
Male Fertility Can Be Restored After Cancer Treatment, Researchers Find
An injection of banked sperm-producing stem cells can restore fertility to male primates who become sterile due to cancer drug side effects, according to researchers. In their animal study, which was published today in Cell Stem Cell, previously frozen stem cells restored production of sperm that successfully fertilized eggs to produce early embryos.
Women Undergoing IVF Report Problems With Sexual Relationship, Study Finds
An Indiana University study has found that women undergoing IVFn report that the process of infertility treatment has many negative impacts on their sexual relationship with their partner. Little attention has been given to the sexual dynamics of couples as they navigate infertility and treatments such as IVF, despite the important role that sex plays in a couple's attempt to conceive a child.
The Queensland Institute of Medical Research (QIMR) says it has made a significant discovery into the causes of the gynaecological disorder endometriosis. The often painful gynaecological condition affects about 10 per cent of Australian women.
Sperm DNA Fragmentation SURVEY [This link may be from a sponsor]
Assessment of Sperm DNA Fragmentation by TUNEL, SCSA, halosperm or other appear very popular but is it? Complete the survey to find out just how many clinics are performing this assay. [Tell your fellow scientists to complete this survey!!]
Expanded Halosperm EQA program. [This link may be from a sponsor]
An EQA/Competency schemes for the assessment of sperm DNA fragmentation by the Halospem method. This has been expanded to 12 data sets for 2013 with images form several users. Participants are shown 20+ sets of images from one sample and asked to estimate the number Normal and abnormal sperm ( according to the methodology) and calculate a % DFI
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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