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Does advancing male age influence the expression levels and localisation patterns of phospholipase C zeta (PLCζ:) in human sperm?
While progressive motility was negatively correlated with male age, all three statistical models concurred that no PLCζ:–related parameter was associated with male age, suggesting that advancing male age is unlikely to cause problems in terms of the sperm’s fundamental ability to activate an oocyte.
Automatic time-lapse instrument is superior to single-point morphology observation for selecting viable embryos: retrospective study in oocyte donatio
Patients where no high embryos were transferred (n = 75) had an OPR of 46.70%, and those patients where at least one high embryo was transferred (n = 109) significantly increased OPR to 67%. A logistic regression analysis - - suggested that if at least one of the embryos was labeled as high, OPR was 2.567 times higher than a cycle where no high embryos were transferred.
How FSH and AMH reflect probabilities of oocyte numbers in poor prognosis patients with small oocyte yields
Anti-Müllerian hormone demonstrated at higher levels (2.5–≥:5 :ng/ml) at all ages almost perfect probabilities (99–100 :%). With declining anti-Müllerian hormone, age categories, however, increasingly diverged, though to lesser degree than follicle stimulating hormone. In poor prognosis patients, follicle stimulating hormone and anti-Müllerian hormone, thus, offer at different ages very specific probabilities for retrieval of 1–&#
A fresh(er) perspective on frozen embryo transfers
In the past decade, we have witnessed a rapid rise in the number of frozen-thawed embryo transfers (FET). Nationally, it has been estimated that the number of FET cycles has increased by 82.5% between 2006 and 2012, while the number of fresh ET cycles has increased by only 3.1% during the same time interval (1). These trends are intriguing given that embryo cryopreservation was traditionally used to cryopreserve supernumerary good-quality embryos
From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies
Today, some of the physiological metabolic phenotypes present in animal models of IVF have begun to emerge in human IVF children, but it remains unclear whether or not in vitro embryo manipulation will have lasting health consequences in the offspring. - As IVF use continues to rise, it will be highly valuable to incorporate DOHaD concepts into the clinical arena and future approaches to public health policy.
The effect of endometrial injury on pregnancy rate in frozen-thawed embryo transfer: A randomized control trial
Conclusion: Based on results of this study, local injury to endometrium in luteal phase prior to FET cycle had a negative impact on implantation and clinical pregnancy rates.
The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial
The average positive percentage of SDF in patients receiving ginger (17.77, 95%CI: 6.16-29.39) was lower compared with placebo (40.54, 95%CI: 23.94-57.13) after three month of treatment (p=0.02). In multivariate analysis, SDF was significantly lower in patients receiving ginger compared with placebo (mean difference: 3.21, 95%CI: 0.78-5.63, p=0.009). There were no significant differences between two groups regarding to semen parameters.-Conclusio
World report on fertility treatments reveals high use of intracytoplasmic sperm injection (ICSI)
The editor-in-chief of one of the world’s leading reproductive medicine journals has attacked the rising use of intracytoplasmic sperm injection (ICSI) for the treatment of infertility, following publication of the latest world report on assisted reproductive technologies (ART) [1] today (Saturday).
PGS for recurrent pregnancy loss: forget it! [from Professor Hans Evers, via ESHRE]
In this month’s issue of Human Reproduction Gayathree Murugappan and colleagues from Stanford and Seattle show that among all attempts at preimplantation genetic screening (PGS) or expectant management in patients with recurrent pregnancy loss (RPL), clinical outcomes including pregnancy rate, live birth rate and clinical miscarriage rate were similar. They conclude that success rates with PGS are limited by the high incidence of cycles that inte
Webinar: Real World Best Practices in IVF Cell Culturing- Continuous pH monitoring
Steven Geelhood (SAFE Sens Project Manager) then shared data collected from labs utilizing the SAFE Sens continuous pH monitory system. Graphs were presented and analyzed for the following scenarios wherein cell culture conditions were manipulated thus causing changes to the pH over time. • Initial equilibration of media with time scale
• Equilibrated media with or without oil
• CO2 set point changes
• Effect of loss of CO2
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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