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Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation
Conclusion(s). Our findings suggest that treatment for infertility does not significantly increase the risk of ovarian cancer among women with a BRCA mutation.
Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic divisi
Conclusion(s). From this preliminary dataset, there is no evidence that AOA causes a widespread increase in chromosome segregation errors in meiosis II. However, we recommend that it be applied selectively to patients with specific indications.
Effect of two assisted oocyte activation protocols used to overcome fertilization failure on the activation potential and calcium releasing pattern
Conclusion(s). In both mouse and human oocytes, the AOA protocol that used ionomycin was more efficient than the one that used A23187. Bearing in mind that mammalian fertilization is successful when the total dose of Ca2+ released reaches a minimal threshold, the use of ionomycin for human AOA might be justified instead of the use of A23187
Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest
-Here, we describe a consanguineous family with a recessive inheritance pattern of female infertility characterized by recurrent early embryonic arrest in cycles of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). We have identified a homozygous PADI6 nonsense mutation (c.1141C>T [p.Gln381∗:]) that is responsible for the phenotype.
Maternal serum screening markers and nuchal translucency measurements in in vitro fertilization pregnancies: a systematic review
Conclusion(s). A decrease in PAPP-A and an increase in total hCG was consistently reported among the included studies. However, owing to the variability in the levels of the other maternal serum screening markers reported and the inability to conduct a meta-analysis, we were unable to generalize about the differences between prenatal screening results in the IVF population.
Anti-Müllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations
BRCA1 mutation carriers had, on average, 25% (95% CI: 5%–41%, P = 0.02) lower AMH concentrations than non-carriers and were more likely to have AMH concentrations in the lowest quartile for age (OR 1.84, 95% CI: 1.11–303, P = 0.02). There was no evidence of an association between AMH concentration and BRCA2 mutation status (P = 0.94).
Effect of ethnicity on live birth rates after in vitro fertilisation/intracytoplasmic sperm injection treatment: analysis of UK national database
Ethnicity is a major determinant of IVF/ICSI treatment outcome as indicated by significantly lower live birth rates in some of the ethnic minority groups compared with white British women. - The cumulative live birth rates showed similar patterns across different ethnic groups.
BRCA1 gene mutation is linked to women having fewer eggs in their ovaries
In the first large study looking at BRCA1 and BRCA2 genetic mutations and levels of anti-Müllerian hormone (AMH) in women who carry the mutated genes, the group of international researchers found that carrying the BRCA1 mutation was associated with AMH concentrations that were, on average, 25% lower than those in non-carriers. The effect was not seen in women with the BRCA2 mutation.
Ethnicity of women undergoing fertility treatment can affect outcomes, study finds
The ethnicity of women undergoing fertility treatments like IVF can affect the rate of successful live births, according to new research. After adjusting for certain factors including age of patient at time of treatment, cause of female or male infertility, and type of treatment, the study found that White Irish, South Asian Indian, South Asian Bangladeshi, South Asian Pakistani, Black African, and Other Asian women had a significantly lower odds
The recent ICMART data (albeit from 2010) show ICSI rates are higher than expected for male infertility and variable between regions
Comment
Apart from financial reason to promote ICSI, there may be several reasons why the ICSI rates are higher than expected. The main ones include the fear of failed fertilisation, a desire to standardize the IVF treatment process and a growing body of data that suggests the risk from using ICSI remain low or negligible.//There are some other comments that can be made including a rising ICSI rate means less emphasis on Andrology workup and assessment of male fertility, less skill retention by embryologists to perform standard IVF and handling cumulus enclosed oocytes and fertilised eggs. Finally, the unfertilised oocyte is the most vulnerable of all stages of embryo culture and be definition means that culture systems need to be of the best quality.
Title
BRAC1 and Low AMH concentrations
Summary
Carriers of BRAC1 mutation appear to have up to a 25% lower AMH concentration than non-carriers matched by age. BRAC2 mutation status was not related to reduced AMH levels.
Comment
While the incidence of BRAC1 is very small (<0.2%), the association between their carrier status and reduced AMH concentration should be noticed. Undoubtedly, most low AMH levels in women over 30 are an indication of reduced oocyte yield and the awareness that a few such women may also be a BRAC1 carrier could be considered a pigeon in a coal mine in so far as low AMH may lead women to IVF and low AMH may lead clinicians to force oocyte stimulation in order to maximise recovery of oocytes. Whether such actions may lead to increased risk of breast cancer is unknown and probably unlikely but given the low incidence of BRAC1 carriers, any increase will be lost in general epidemiological research. One wonders if clinics may need to be aware of a potential risk and offer BRAC1 testing to older women with low AMH before treatment. Indeed, knowing the link exists and not testing may well be a factor in any case where a women has breast cancer IVF treatment. Comments?
IVF Training - Questions relating to mailout links -
Open Challenge and complete Questions
Question
Type
Options
AMH levels are related to BRAC1 carrier status
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AMH Levels Are Related To BRAC2 Carrier Status
1
2
AMH levels in women who are carriers of the BRAC1 mutation are:
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AMH levels in women who are carriers of the BRAC1 mutation are:
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IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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