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Adjuvant gonadotrophin-releasing hormone agonist trigger with human chorionic gonadotrophin to enhance ooplasmic maturity
The results suggest that combined GnRHa and HCG trigger in ICSI cycles is a reasonable approach to increase oocyte maturity, specifically ooplasmic maturity, thereby increasing fertilization and improving ICSI cycle outcomes in patients with a history of poor fertilization after standard HCG trigger alone.
Combined effects of individual culture and atmospheric oxygen on preimplantation mouse embryos in vitro
Compared with controls, hatching rate and cells per blastocyst were reduced in 5% oxygen single culture and 20% oxygen group culture (134.1 ± 3.4, 104.5 ± 3.2, 73.4 ± 2.2 cells, P < 0.001), and were further reduced in 20% oxygen individual culture (57.0 ± 2.8 cells, P < 0.001), as was percentage inner cell mass. These data indicate combining individual culture and 20% oxygen is detrimental to embryo development.
Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and ‘OMICS’: Is looking good still important?
The clinical introduction of time-lapse systems has reopened our eyes and given us a new vantage point from which to view the beauty of the initial stages of human life. Rather than a future in which the morphology of the embryo is deemed irrelevant, we propose that key features, such as multinucleation and cell size, should be included in future iterations of selection/de-selection algorithms.
ZIKV preferentially infected spermatogonia, primary spermatocytes, and Sertoli cells in the testis, resulting in cell death and destruction of the seminiferous tubules. Less damage was observed with a contemporary Asian ZIKV strain (H/PF/2013), in part because this virus replicates less efficiently in mice. The extent to which these observations in mice translate to humans remains unclear, but longitudinal studies of sperm function and viability
Some of Australia's major IVF clinics have changed how they advertise success rates after an investigation by the Australian Competition and Consumer Commission (ACCC) found a number had made misleading claims which could confuse consumers.
World's first baby using controversial three-parent technique born, report says
The world's first baby using a controversial new technique employed by US scientists to include DNA from three parents in the embryo has been born, a report says. The baby boy was born five months ago in Mexico to Jordanian parents, and is healthy and doing well, said the report in New Scientist magazine. The boy`s mother carried genes for a disorder known as Leigh Syndrome, a fatal nervous system disorder which she had passed on to her two previ
Licorice compound interferes with sex hormones in ovary
A study of mouse reproductive tissues finds that exposure to isoliquiritigenin, a compound found in licorice, disrupts steroid sex hormone production in the ovary, researchers report. This is the first study to examine the effects of this chemical on the ovary.
Zika infection causes reduced fertility, low testosterone in male mice
Zika targets the male reproductive system, at least in mice, say researchers. Three weeks after Zika infection, male mice had shrunken testicles, low levels of sex hormones and reduced fertility. The results suggest that Zika infection may interfere with men's ability to have children.
GnRHa and hCG improves the outcome of cases with previous poor ICSI fertilisation.
Summary
The use of a dual trigger for cases with poor ICSI fetilisation is a good treatment option.
Comment
Poor fertilisation after ICSI is a relatively low occurrence since most oocytes are mature (with polar body) at injection. Where the rates are low (<40%), doubts are usually directed toward sperm quality (or the whole culture system). This article suggested that oocyte cytoplasmic maturation may be an issue and by inducing ovulation with both hCG (LH receptor) and GnRHa (both LH and FSH receptors) stimulation improves oocyte yield, fertilisation and pregnancy. |For clinicians, having an alternative treatment option for the next cycle is always good to have at hand. In this case, it may also improve the chance of pregnancy. |Whether the GnRHa co-ovulation tool improves cytoplasimic maturation ( for example, think sperm derived lipase C and calcium oscillations after fertilisation), a role for FSH at ovulation (what happens during normal ovulation) or a deceased sensitivity of the LH receptors to hCG, the article reminds us that all IVF centers around the ovulation process but is one that almost all take for granted. It would be interesting to see a followup paper on this topic to see what proportion of poor ICSI fertilisations may respond to this treatment.|
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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