Comment:I have listed a few links to articles involves in DNA repair after fertilisation - very sparse indeed. If you know of other references on DNA repair at the pronuclear stage please post the URL to office@fertaid.com - Plus some good links to articles on fast/slow growing embryos
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Loss of Genomic Imprinting in Mouse Embryos with Fast Rates of Preimplantation Development in Culture
We conclude that faster development rates in vitro are correlated with loss of genomic imprinting and aberrant metabolic marker expression. Importantly, we identified a subset of in vitro cultured embryos that, according to the parameters evaluated, are very similar to in vivo derived embryos and thus are likely most suitable for embryo transfer.
The Activation of DNA Damage Detection and Repair Responses in Cleavage-Stage Rat Embryos by a Damaged Paternal Genome
Thus, paternal cyclophosphamide exposure activated a DNA damage response in cleavage-stage embryos. Furthermore, this damage response may be useful in assessing embryo quality and developmental competence.
Male mice produced by in vitro culture have reduced fertility and transmit organomegaly and glucose intolerance to their male offspring.
Suboptimal IVC reduced the expression of Kap1, Sox2, Hdac1, Dnmt1, and Dnmt3a, suggesting a molecular epigenetic role for gene expression modifiers in the origin and transmission of these abnormal phenotypes.
Paternal DNA damage resulting from various sperm treatments persists after fertilization and is similar before and after DNA replication.
This study provides evidence that subjecting sperm to DNA damage-inducing treatments results in degradation of highly condensed sperm chromatin when it is still packed within the sperm head, and that this DNA damage persists after fertilization. The difference in DNA damage in sperm subjected to 2 treatments was ameliorated in the fertilized oocytes, suggesting that some chromatin repair might have occurred. This process, however, was independent
One, two or three: how many directions are useful in transvaginal
ultrasound measurement of ovarian follicles?
In non-stimulated menstrual cycles, follicle measurement in only one direction is less accurate than measurement in two and three directions, and may result in clinically relevant differences. However, measurement in three directions gives no additional information compared to measurement in two directions.
Definition and Measurement of Follicle Stimulating Hormone [for those interested in measuring serum FSH by immunoassay JDS]
Several highly purified standards for FSH are now available, but discontinuity and heterogeneity of estimates of FSH activity in terms of these standards made using in vitro assays and binding assays have been noted. It is thus essential that any measurement of FSH include specification both of the standard with which the measured FSH is compared and the assay method used for that comparison
Attaining dominance in vivo: distinguishing dominant from challenger follicles in humans [for those interested in follicle growth/interactions ]
Furthermore, dominant follicles subsequently appeared to reduce the number of neighbouring challenger follicles. The results strongly suggest that a paracrine secretion of the dominant follicle was the source of this localized effect. This process may provide increased nutrient level and space at a critical growth stage for dominant follicles
Changes in endometrial thickness, width, length and pattern in
predicting pregnancy outcome during ovarian stimulation in IVF cycles
Conclusion The endometrial features as assessed by transvaginal ultrasound do not provide significant prognostic information with regard to the outcome of in vitro fertilization
DNA Microarray Reveals That High Proportions of Human Blastocysts from Women of Advanced Maternal Age Are Aneuploid and Mosaic
Biopsy from TE in blastocysts does not exactly predict the chromosomal information in ICM if the embryos are aneuploid. Some mosaic blastocysts have euploid ICM, which may indicate important differentiate mechanism(s) of human preimplantation embryos.
Herbal supplements in pregnancy: unexpected results from a multicentre study
Almond oil users showed more pre-term birth (29 of 189) than non-users (51 of 511). After adjusting for multiple pregnancies, smoking, advanced age and drug intake, almond oil users maintained an increased risk to give birth <37th week (odds ratio = 2.09, 95% confidence interval: 1.08–4.08).
Faster-growing embryos exhibited more perturbation in genomic imprinting, suggesting an inability to faithfully maintain epigenetic information when embryos transition too rapidly through the first few embryonic divisions. This could potentially result from the stress imposed by less than adequate culture conditions
Characterizing the influence of vitamin D levels on IVF outcomes
Vitamin D deficiency is associated with lower pregnancy rates in non-Hispanic whites, but not in Asians, possibly due to their lower IVF success rates. Vitamin D deficiency was not correlated with ovarian stimulation parameters or with markers of embryo quality, suggesting its effect may be mediated through the endometrium.
The association between severe obesity and characteristics of failed fertilized oocytes
Significantly more oocytes from the severely obese group exhibited two spindles compared with those from the normal BMI group (58.9 versus 35.1%: OR = 2.68, CI = 1.39–5.15, P-value = 0.003)/ Among oocytes with a single spindle, those from severely obese patients showed a significantly higher prevalence of disarranged spindles with non-aligned chromosomes compared with those from normal BMI patients
Maternal menopause as a predictor of anti-Müllerian hormone level and antral follicle count in daughters during reproductive age
We demonstrated a significant, positive association between age at maternal menopause and serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) in daughters. The rate of decline in serum-AMH level and AFC is also associated with age at maternal menopause.
Motile sperm organelle morphology evaluation-selected globozoospermic human sperm with an acrosomal bud exhibits novel patterns and higher levels of P
MSOME identified round-headed globozoospermic sperm with increased levels of PLCζ: relative to sperm from the same sample that did not undergo MSOME, and identified novel patterns of PLCζ: localization in sperm exhibiting an acrosomal bud. [Better to select an individual sperm for ICSI without AOA JDS]
New Assessment Reveals Value of Second Embryo Biopsy for Women of Advanced Maternal Age
An elegant new study confirms that the most commonly used method of screening for embryo abnormalities following in vitro fertilization (IVF) does accurately predict the success of embryo transplantation for younger women, but not necessarily for those of advanced maternal age.
Private sperm donor ordered to pay child support [BioNews]
A man who donated his sperm to a lesbian couple 13 years ago in a private arrangement has been ordered to pay child support. He has called on the Government to make changes in the law so that private sperm donors are treated fairly. Mark Langridge met the couple in 1997 and they became close friends. When one of the women expressed her desire have children, Langridge agreed to donate his sperm in 1998 and again one year later. The woman became p
Gay sperm donor told to pay child maintenance for 'his' two children
A gay man from Essex who donated his sperm to enable a lesbian couple to have two children, but who was never named on their birth certificate and had no role in their upbringing, is being forced by the Child Support Agency to pay for their support – 13 years after the first child was born.
Glasgow centre buyout births UK's largest IVF provider [BioNews]
The Academic Research Partnership (ARP) has bought a majority stake in the Glasgow Centre for Reproductive Medicine (GCRM), reportedly creating the UK's largest provider of NHS and private IVF services. According to a statement, the move is ARP's third 'partnership' in the UK and follows mergers with the Oxford Fertility Unit and IVF Hammersmith.
A specialist fertility group has bought a majority stake in the Glasgow Centre for Reproductive Medicine (GCRM). Academic Research Partnership (ARP) said the multi-million pound deal created the UK's largest single provider of both NHS and private IVF services.
Fertility 'predicted by mother's age at menopause'
Women may be able to better gauge their own fertility based on the age their mother went through the menopause, a study has concluded. Women whose mothers had an early menopause had far fewer eggs in their ovaries than those whose mothers had a later menopause, a Danish team found
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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