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Glycolysis-Optimized Conditions Enhance Maintenance of Regenerative Integrity in Mouse Spermatogonial Stem Cells during Long-Term Culture
To address these deficiencies, we optimized the culture environment to favor glycolysis as the primary bioenergetics process. In these conditions, regenerative integrity of pup and adult SSCs was significantly improved and the efficiency of establishing primary cultures was 100%. Collectively, these findings suggest that SSCs are primed for conditions favoring glycolytic activity, and matching culture environments to their bioenergetics is critic
The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis
Our study reveals a novel role for Wt1 in early mammalian development and identifies proteases as critical mediators of the maternal-embryonic interaction. Our data also suggest that the role of Wt1 in regulating fertility is conserved in mammals.
Euploidy rates in donor egg cycles significantly differ between fertility centers
This is the first study to show a strong association between center-specific ART treatment practices and the incidence of chromosome abnormality in human embryos, although the meiotic or mitotic origin of these abnormalities could not be determined using these technologies.
Researchers improve technology to save sperm stem cells
Method key to preserving fertility of boys with cancer
Adult men can have their sperm frozen before undergoing radiation or chemotherapy, both of which can render sperm infertile. But boys who haven't been through puberty can only have sperm stem cells removed and frozen in anticipation of technology that could culture the cells and place them back in the testes, where they produce sperm after puberty.
It has been estimated that more than 80 million people in the world have an unfulfilled desire to have children. But for every 10th couple, the reasons therefore remain unclear. Now, researchers have found a new gene mutation that obviously leads to infertility in women. The mutated gene WT1 plays an important role in the early embryonic development controlling proteins (especially proteases) that are needed for the successful nidation in mother’
Insurance coverage for IVF increases chance of having baby
Women who pursue in vitro fertilization (IVF) to become pregnant are more likely to give birth if they have health insurance that covers the procedure, according to new research. The key reason is financial rather than medical: For many people, the high cost for one IVF procedure prohibits women from seeking a second treatment if the first attempt fails.
Sperm-hybrid micromotor for drug delivery in the female reproductive tract
Here, the single sperm cell serves as an active drug carrier and as driving force, taking advantage of its swimming capability, while a laser-printed microstructure coated with a nanometric layer of iron is used to guide and release the sperm in the desired area by an external magnet and structurally imposed mechanical actuation, respectively.
Sperm Are Being Turned Into Tiny Weapons to Attack Gynaecological Cancer
Getting enough toxic material to the right place in your body for it to kill tumours – while not damaging anything else – has always required thinking outside of the box. Wrapping sperm cells in an iron suit and then guiding them to a target using magnetic fields could be one innovative way to deliver drugs to parts of the female reproductive system affected by cancer.
Fertility can hinge on swimming conditions in the uterus
A researcher has found that the uterus in female mice contains enzymes that can break down semen, making it less gel-like, more watery, and therefore easier to swim in. This interplay between semen and the female reproductive tract can impact fertilit
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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