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Vitrification of Human Germinal Vesicle Oocytes: before or after In Vitro Maturation?
Conclusion: In stimulated cycles, vitrification of in vitro matured MII oocytes rather than GV oocytes seems to be more efficient. This approach needs to be verified in nonstimulated fertility preservation cases.
Quadrupling efficiency in production of genetically modified pigs through improved oocyte maturation
The efficiency of production of genetically altered piglets for agricultural and biomedical purposes is very low, in large part because of the poor quality of the in vitro-matured oocytes used to initiate the process. Here, we describe a chemically defined culture medium that enhances porcine oocyte maturation and subsequent embryo development to the blastocyst stage, and increases the number of offspring born after embryo transfer, thereby effe
Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice
We thus suggest that elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance.
New technique overcomes genetic cause of infertility
Scientists have created healthy offspring from genetically infertile male mice, offering a potential new approach to tackling a common genetic cause of human infertility
Fertile offspring from sterile sex chromosome trisomic mice
We show that during reprogramming to induced pluripotent stem cells (iPSC), fibroblasts from sterile trisomic XXY and XYY mice lose the extra sex chromosome, by a phenomenon we term trisomy-biased chromosome loss (TCL). Resulting euploid XY iPSCs can be differentiated into the male germ cell lineage and functional sperm that can be used in intracytoplasmic sperm injection to produce chromosomally normal, fertile offspring. Sex chromosome loss is
Successful maintenance of key physiological parameters in preterm lambs treated with ex vivo uterine environment therapy for a period of 1 week
Five preterm lambs were maintained in a physiologically stable condition for 1 week with significant growth and without clinically significant bacteremia or systemic inflammation. Although substantial further refinement is required, a life support platform based around ex vivo uterine environment therapy may provide an avenue to improve outcomes for extremely preterm infants.
Flame retardants and likelihood of pregnancy in women undergoing fertility treatments
Women with higher urinary concentrations of a common type of flame retardant had reduced likelihood of clinical pregnancy and live birth than those with lower concentrations, according to researchers. The study is among the first to examine associations between organophosphate flame retardants (PFRs) - which are used in polyurethane foam in many products, including upholstered furniture, baby products, and gym mats - and reproductive outcomes in
An artificial womb has been successfully used to incubate healthy baby lambs for a period of one week, and researchers hope the technology will one day be able to do the same for extremely premature babies.
Female mouse embryos actively remove male reproductive systems
A protein called COUP-TFII determines whether a mouse embryo develops a male reproductive tract, according to new research. The discovery changes the long-standing belief that an embryo will automatically become female unless androgens, or male hormones, in the embryo make it male.
Human in vitro fertilization could evolve thanks to piglet study
It is estimated that parents seeking to have children through in vitro fertilization (IVF) spend between $12,000 and $15,000 each session plus the cost of medications, which could average between $3,000 and $5,000. Now, researchers have made a discovery that could decrease the costs associated with IVF in humans - and it all started with piglets.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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