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Obstetric and perinatal outcomes of pregnancies conceived with embryos cultured in a time-lapse monitoring system
No detrimental effects were observed in obstetric and perinatal outcomes when a time-lapse incubator was used rather than a more widely used conventional incubator. As far as we know this is the first report from a randomized study of the neonatal outcomes of time-lapse monitoring. Our results suggest that this technology is an effective and safe alternative for embryo incubation, though trials of larger numbers of patients are required to furthe
The impact of unilateral oophorectomy on ovarian reserve in assisted reproduction: a systematic review and meta-analysis
Conclusions:Available pooled data supports an adverse effect of UO on ovarian reserve involving the quantity but not the quality of the ovarian pool. - However, the weighted overall odds ratio (OR) of clinical pregnancy between women with a single ovary and women with two ovaries was comparable (overall OR 0.76: 95% CI 0.57 to 1.00, P=0.054).
Controlled ovulation of the dominant follicle using progestin in minimal stimulation in poor responders
Conclusion
This study supported the hypothesis that P-primed minimal stimulation achieved ovulation control of the dominant follicle and did not adversely affect the quality of oocytes in poor responders. Therefore, P-priming is a promising approach to overcome premature ovulation in minimal stimulation for poor responders.
Predicting Implantation Outcome of In Vitro Fertilization and Intracytoplasmic Sperm Injection Using Data Mining Techniques
Out of 20 factors, the age of woman, number of developed embryos, and serum estradiol level on the day of human chorionic gonadotropin administration are the three best features for such prediction.
Effect of oocyte vitrification on embryo quality: time-lapse analysis and morphokinetic evaluation
Conclusion(s):The embryo quality of vitrified oocytes was not impaired: cc2, quality according to our hierarchic morphokinetic model, and implantation rates were similar between fresh and vitrified oocytes. However, morphokinetic differences were observed from t2 to tB. Our main study limitation was the retrospective nature of the analysis, although a large database was studied.
Endometrial thinness is a common cause of infertility that is often refractory to hormonal therapy, a condition referred to as refractory endometrium, and it frequently leads to repeated implantation failure.
It is ethical to recommend against assisted reproductive treatment for women with a high body mass index
No Abstract- [Authors argue that restriction to overweight clients is inconsistent with their pregnancy rates compared to many older clients where access is not restricted.]
Jean Marian Purdy remembered – the hidden life of an IVF pioneer
Jean Purdy is almost forgotten as one of the British trio that introduced clinical IVF to the world. An unlikely pioneer, she qualified as a nurse but through indefatigable effort and unstinting loyalty to a programme that faced vitriolic opposition she became the clinical embryologist for the first IVF baby. In 1980, she helped to launch fertility services as the ‘Technical Director’ of Bourn Hall Clinic, near Cambridge.
Outcomes from a university-based low-cost in vitro fertilization program providing access to care for a low-resource socioculturally diverse urban com
Conclusion(s): Use of mild stimulation protocols, simplified monitoring, and minimized laboratory handling procedures enabled access to care in a low-resource socioculturally diverse infertile population. Overall, cumulative live birth rates per retrieval including subsequent use of frozen embryos was 29.0%: 44.6% (29/65) of patients enrolled in the program achieved pregnancy.
Even though clients with one ovary following unilateral oophorectomy have fewer oocytes their chance of pregnancy is not reduced.
Comment
You do not come across many clients with only one ovary very often but as this study has shown doing a Cochrane and other data searches, their chance of an ongoing pregnancy has not diminished compared to clients with two ovaries. The study reported that women with a single ovary had higher FSH and lower max E2 at hCG but when following transfer had the same pregnancy rate. One assumes they had fewer oocytes and embryos and possibly fewer embryos for transfer. The study shows that each ovary has a least one viable follicle (presumably well vascularised) that is capable of raising a viable oocyte. This is important information for clinicians providing clients with realistic data on their chance of success.
Title
Efficacy of low cost IVF treatment
Summary
Mild stimulation with fewer egg numbers can lead to a very satisfactory live birth rate of 44%/collection (inc freash and frozen transfers)
Comment
This low number study using clients of good reproductive ages (~ 33 years old) using a variety of mild stimulation protocols reported a live birth rate per collections (including both fresh and frozen transfers) of 44%. Of course with many low dose protocols there was a higher than usual cancellation rate (inc premature ovulation) of 35%. This rate would be considered unacceptable in most clinics where <5% is common (there are more cancelled transfers but that is another story). The point of this article is that if one pursues a mild stimulation protocol,there are fewer oocytes and thus fewer surplus embryos to freeze therefore using a cumulative pregnancy rate where both fresh and frozen transfers are grouped and expressed per collection gives the global chance of pregnancy to clients per stimulation cycle. All the costs and risks and client involvement are associated with the fresh transfer while frozen cycles are the opposite. Using cumulative rates is the best way to balance these factors. //Also there is no risk of hyperstimulation and post collections limitation allowing clients to return to a FET cycle as soon as possible. It also allows unsuccessful clients to return for another collection cycle very quickly. There is little or no PGD nor extended culture. For many clients where IVF has become very expensive, low cost, easy to repeat cycles may seems an attraction option where they have time on their side to undertake a few attempts. Older women may not be prepared to do so.
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Open Challenge and complete Questions
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In A Review Of A Randomised Trial On Time-Lapse Monitoring, The Difference In Pregnancy Rates Was
1
5
In A Review Of A Randomised Trial On Time-Lapse Monitoring, The Difference In The Multiple Pregnancy Rates Was
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5
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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