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Morphokinetic analysis of human embryo development and its relationship to the female age: a retrospective time-lapse imaging study
There was no significant difference in average morphokinetic time-points among young versus old women.Whereas timely cleaved embryos showed significant difference in tPNa i.e. time for pronuclear appearance (P≤: 0.001), t4 and t5 i.e. time for 4 and 5-cell cleavage (P≤: 0.05)among different age groups.
Reproductive outcomes in recipients are not associated with oocyte donor body mass index up to 28 :kg/m2: a cohort study of 2722 cycles
Clinical pregnancy rates and live birth rates (LBR) were no different with increasing donor BMI (up to donor BMI ≤:28 :kg/m2). The odds of pregnancy did not vary with donor BMI.- A reduced odds of clinical pregnancy was observed with increasing recipient BMI.-A negative effect on oocyte donation cycle outcomes with increased donor BMI was not found after adjusting oocyte donor and recipient BMI.
Paving the way for a gold standard of care for infertility treatment: improving outcomes through standardization of laboratory procedures
The current approach to IVF is fragmented, with various protocols in use. A systematic approach to establishing optimum best practices may improve IVF success and live birth rates. Our vision of the future is that technological advancements in the laboratory setting are standardized and universally adopted to enable a gold standard of care. Implementation of best practices for laboratory procedures will enable clinicians to generate high-quality
There is, otherwise, only one other lesson to be learned from this case, this time relevant to the FDA and other regulatory agencies around the world. What this case demonstrates so well is that if responsible scientists are prohibited from performing responsible research under appropriate guidelines and safeguards, the research will go elsewhere, where there exist neither guidelines, safeguards, nor responsible researchers.
First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation [PDF]
In this issue, Zhang et al. (2017) report the birth of a healthy boy after mitochondrial replacement therapy (MRT) by spindle transfer to prevent transmission of mitochondrial disease from mother to child. The case was first publicized in the lay press (Hamzelou, 2016: see also editorial by Johnson, 2016) and then presented during the 2016 Annual Meeting of the American Society for Assisted Reproduction (ASRM) in October 2016 (Zhang et al., 2016a
Significant correlation between anti-müllerian hormone and embryo euploidy in a subpopulation of infertile patients
Using multivariate regression controlling for age, antral follicle count, body mass index and parity, there was a significant association between serum AMH and proportion of euploid embryos (P = 0.02), due to the dominant ≤:36 age group in which significant correlation between AMH and euploidy rate (P = 0.02) was demonstrated. Clinical outcome was similar, including biochemical, clinical and ongoing pregnancy rates as well as pregnancy loss.
The Vienna consensus: report of an expert meeting on the development of ART laboratory performance indicators
Minimum performance-level values (‘competency’) and aspirational (‘benchmark’) values were recommended for a total of 19 Indicators, including 12 Key Performance Indicators (KPIs), five Performance Indicators (PIs), and two Reference Indicators (RIs).
Cumulative live birth rate following elective single blastocyst transfer compared with double blastocyst transfer in women aged 40 years and over
DBT group achieved higher LBRs (26.5 versus 19.3%, P = 0.017) and higher multiple births (0 versus 17.5%, P = 0.02). The cumulative LBR was similar (28.0 versus 31.1%), with lower multiple births in the eSBT group (0 versus 14.9%, P = 0.03). These results indicate that in women aged 40–43, when fully expanded blastocysts are achieved, maternal age is not a predictor for live birth, and eSBT can be performed without compromising cumulative LBRs
Effect of micronutrient supplementation on IVF outcomes: a systematic review of the literature
However, all the studies reported a positive impact of micronutrient supplementation on clinical outcomes of IVF therapy in terms of pregnancy rate and/or live birth rate. Within the limits of this review, micronutrients appear to influence positive outcomes in couples undergoing fertility treatment.
In vitro culture of individual mouse preimplantation embryos: the role of embryo density, microwells, oxygen, timing and conditioned media
Addition of embryo-conditioned media to single embryos increased hatching rate and blastocyst cell number (91.5 ± 4.7 versus 113.1 ± 4.4: P < 0.01). Single culture before or after compaction is therefore detrimental: oxygen, media volume and microwells influence single embryo development: and embryo-conditioned media may substitute for group culture.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
New Developments at FertAid during
February, 2026 and February, 2026
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