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Does freeze-all policy affect IVF outcomes in poor responders?
Conclusions: In this study, the freeze-all strategy had no impact on IVF outcomes among poor responders according to the Bologna criteria. Multi-centric study including a large number of patients should be carried out to extend the results of our study to reach conclusions about the benefits offered to poor responders.
Effects of intrauterine perfusion of human chorionic gonadotropin in women with different implantation failure numbers
Conclusion: Pregnancy rates decreased with the number of transplant failures. The intrauterine administration of hCG before FET significantly improved the pregnancy rates, especially after one and three or more implantation failures.
Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability
Finally, time intervals between discrete fertilization events were strongly associated with embryo quality on Day 3. For example, longer intervals between disappearance of the cytoplasmic halo and PN breakdown were highly predictive of reduced blastomere number and increased fragmentation (P = 0.0001).
Effects of intrauterine perfusion of human chorionic gonadotropin in women with different implantation failure numbers
Conclusion: Pregnancy rates decreased with the number of transplant failures. The intrauterine administration of hCG before FET significantly improved the pregnancy rates, especially after one and three or more implantation failures.
Assisted reproductive technology (ART) cumulative live birth rates following preimplantation genetic diagnosis for aneuploidy (PGD-A) or morphological
Compared to the control group, the PGD-A group achieved a higher per cycle live-birth rate (14.47% vs 9.12%, P < 0.01), took a shorter mean time to reach a clinical pregnancy leading to a live-birth (104.8 days vs 140.6 days, P < 0.05) and required fewer cycles to achieve a live-birth (6.91 cycles vs 10.96 cycles, P < 0.01). However, after three ‘complete ART cycles’, the CLBR was comparable for the two groups (30.90% vs 26.77%, P = 0.34).
Is freeze-all a better strategy for poor responders.
Summary
An in-house study of 433 cycles involving poor responders did not show any difference in clincal outcomes for fresh transfers against freeze-all, FET transfers.
Comment
The decision as to whether to perform a fresh ET or freeze all followed by a FET in a subsequent cycle failed to demonstrate any advantage of cryostoring a couples embryos and transferring to them in a future cycle where the endometrium may be normalised. Given the decision to freeze all included patient choice, a thin endometrium or elevated progeseterone at trigger, the two groups were not exactly the same since many of the freeze-all patients had some clinical indicators of poor implantation.// The risk of course with any freeze all event is that perfectly good embryos may not survive or their potential may be diminished by freezing. Vitrification has however transformed cryostorage and despite its precarious process continues to demonstrate superior embryo survival. So the risk of freeze-all is less now than say 5 or more years ago. Not withstanding the superiority of vitrification/cryopreservation, this study does not suggest inadequate endometrium is an issue with poor responders (since they normally have low E2 concentrations) and that freezing all good embryos has no additional gain and in this case merely extends the time between cycles.//
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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