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Embryo development until blastocyst stage with and without renewal
of single medium on day 3 [PDF Download]
Conclusion: No statistically significant difference was
found between the groups with respect to the analyzed parameters.
However, a non-significant trend was observed
in favor of the group without medium renewal for clinical
pregnancy and positive pregnancy rates (β::::-hCG).
Low dosing of gonadotropins in in vitro fertilization cycles for women with poor ovarian reserve: systematic review and meta-analysis [Meta Analysis]
We found no evidence of a difference in pregnancy outcomes between low doses of gonadotropins and gonadotropins combined with oral compounds compared with high doses of gonadotropins in ovarian stimulation regimens. Whether low doses of gonadotropins or gonadotropins combined with oral compounds is to be preferred is unknown, as they have never been compared head to head. A health economic analysis to test the hypothesis that an ovarian stimulati
IVF Transfer of Fresh or Frozen Embryos in Women without Polycystic Ovaries
Among infertile women without the polycystic ovary syndrome who were undergoing IVF, the transfer of frozen embryos did not result in significantly higher rates of ongoing pregnancy or live birth than the transfer of fresh embryos.
A French start-up’s promotion of expensive radiation-shielding silver-fibre underwear at last weeks’ global Consumer Electronics Show has rekindled debate about the dangers of men carrying smartphones in their pockets.
Osel’s LACTIN-V Enters Clinical Study to Improve the Success Rate of IVF in Women With Imbalanced Vaginal Microbiomes
Study based on findings that women with abnormal vaginal microbiota had only 9% success of pregnancy with IVF versus 44% for those with healthy vaginal bacteria levels
Is changing embryo culture medium after day 3 detrimental?
Summary
In a small, in-house study using donor oocytes, there was no apparent negative effect on outcome from leaving embryos in the same culture drop from day 1 to day 5.
Comment
This small, in-house study explored whether leaving embryos in the same culture medium from day 0/1 to day 5 was detrimental in any way to the outcome of the treatment cycle. The published data suggested it was not. This follows on from other studies also showing the same outcome - that is not changing the medium after 2 days of culture (when one is using global medium) does not appear to impact on embryo development.// This kind of in-house study has probably been done by other clinics and not published but it is an impotent observation. Most clinics will offer blastocyst culture to some or all of their clients, and changing embryos on day 3 involves considerable extra work including dish preparation the day before moving them and the actual transfer. Clinics using time-lapse technology also find changing the dishes on day 3 is inconvenient and losses the continuity of image processing. Often this function is carried out on the weekend which can be inconvenient and expensive for some staff. It involves extra media and dishes and space in the incubators for equilibration. If there are extra-embryonic factors in the culture media, these are lost.// The concept of changing the media after 2 days goes back a long way when concerns about ammonium buildup and embryo metabolism would the main topics of the day. However these concerns no longer have the same level of concern. The concept of sequential media remains an important topic for embryo labs and changing methodology is always difficult but this type of data may well cause some clinics to cease performing this step. //However, given the secretive nature of medium companies, it may be wrong to assume all global media will give the same outcome and given the complex nature of culture vessels and incubators, etc i.e. one own unique culture environment, it may be wise of each clinic to perform (with ethcial approval) a similar analysis and to monitor via clinics KPI dataset if such a change is OK.//Also there is a risk that clinics may no longer look at their embryos on day 2 or 3, waiting until day 5 to see if there are embryos to transfer. I personally would be concerned if this was the case since early cleavage examinations are a good monitor of culture conditions and clients may need reassurance on the likelihood of having a transfer.//
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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