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Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants
Mitochondrial DNA transferred with the nuclear genome was initially detected at levels below 1%, decreasing in blastocysts and stem-cell lines to undetectable levels, and remained undetectable after passaging for more than one year, clonal expansion, differentiation into neurons, cardiomyocytes or β::-cells, and after cellular reprogramming. Stem cells and differentiated cells had mitochondrial respiratory chain enzyme activities and oxygen c
National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys
We analyzed demographic and reproductive household survey data to reveal global patterns and trends in infertility. Independent from population growth and worldwide declines in the preferred number of children, we found little evidence of changes in infertility over two decades, apart from in the regions of Sub-Saharan Africa and South Asia. Further research is needed to identify the etiological causes of these patterns and trends.
After autologous transplant, the donor genotype from lentivirus-marked SSCs was evident in the ejaculated sperm of 9/12 adult and 3/5 prepubertal recipients after they reached maturity. Allogeneic transplant led to donor-recipient chimerism in sperm from 2/6 adult recipients. Ejaculated sperm from one recipient transplanted with allogeneic donor SSCs were injected into 85 rhesus oocytes via intracytoplasmic sperm injection. Eighty-one oocytes wer
Childlessness, parental mortality and psychiatric illness: a natural experiment based on in vitro fertility treatment and adoption
Conclusions Mindful that association is not causation, our results suggest that the mortality rates are higher in the childless. Rates of psychiatric illness do not appear to vary with childlessness, but the rate of psychiatric illness in parents who adopt is decreased.
Semen Concentration and Quality Fell in French Men Between 1989 and 2005
New research shows that the concentration of sperm in men's semen has been in steady decline between 1989 and 2005 in France. In addition, there has been a decrease in the number of normally formed sperm.
Should Australia's surrogacy law allow women to be paid for helping infertile couples? Barbara Miller says while payment raises ethical dilemmas, there's no doubt current law needs to be changed.
Continuous Single CultureTM Comparison of Clinical Outcomes using a SingleStep Uninterrupted Culture Medium Protocol Requiring No Medium Renewal vs. a
Continuous Single CultureTM Comparison of Clinical Outcomes using a SingleStep Uninterrupted Culture Medium Protocol Requiring No Medium Renewal vs. a Traditional Three-Step Sequential Medium System. [from Irvine scientific Web Site - This is not a paid notice Jim Stanger]
Global Rates of Infertility Remain Unchanged Over Past 2 Decades
In 2010, almost 50 million couples worldwide were unable to have a child after five years of trying. Infertility rates have hardly changed over the past 20 years, according to a study by international researchers published in this week's PLOS Medicine.
Overweight Pregnant Women Not Getting Proper Weight-Gain Advice, Study Suggests
Overweight women are not receiving proper advice on healthy weight gains or appropriate exercise levels during their pregnancies, according to Penn State College of Medicine researchers.
Death Rate Two to Four Times as High Among Childless Couples
Despite the popular belief among parents that having children shortens their lives, the reverse seems to be true, particularly for women, indicates a large study of childless couples, treated for infertility, and published online in the Journal of Epidemiology and Community Health.
Stem Cell Research Provides Hope for Infertile Cancer Survivors: Transplanted Stem Cells Could Preserve Male Fertility
A UTSA professor has now demonstrated that it is possible to remove testicular stem cells from a monkey prior to chemotherapy, freeze them and later, after cancer treatments, transplant these cells where they can restart sperm production and restore fertility.
Preventing Inherited Disorders in Humans: New Technology Allows Transfer of Cell Nuclei Between Human Egg Cells
A joint team of scientists from The New York Stem Cell Foundation (NYSCF) Laboratory and Columbia University Medical Center (CUMC) has developed a technique that may prevent the inheritance of mitochondrial diseases in children
Sperm DNA Fragmentation SURVEY [This link may be from a sponsor]
Assessment of Sperm DNA Fragmentation by TUNEL, SCSA, halosperm or other appear very popular but is it? Complete the survey to find out just how many clinics are performing this assay. [Tell your fellow scientists to complete this survey!!]
Expanded Halosperm EQA program. [This link may be from a sponsor]
An EQA/Competency schemes for the assessment of sperm DNA fragmentation by the Halospem method. This has been expanded to 12 data sets for 2013 with images form several users. Participants are shown 20+ sets of images from one sample and asked to estimate the number Normal and abnormal sperm ( according to the methodology) and calculate a % DFI
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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