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Risk of prostate cancer for men fathering through assisted reproduction: nationwide population based register study
Conclusions: Men who achieved fatherhood through assisted reproduction techniques, particularly through ICSI, are at increased risk for early onset prostate cancer and thus constitute a risk group in which testing and careful long term follow-up for prostate cancer may be beneficial.
Is it ever morally permissible to select for deafness in one’s child?
. In this paper I apply Elizabeth Barnes’ value-neutral model of disability as mere-difference to the case of selecting for deafness. I draw on evidence from Deaf Studies and Disability Studies to build an understanding of deafness, the Deaf community, and the circumstances relevant to reproductive choices that may obtain for some Deaf families. Selection for deafness, with deafness understood as mere-difference and valued for its cultural identi
Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis pati
Conclusion(s) PGT-A did not improve overall pregnancy outcomes in all women, as analyzed per embryo transfer or per ITT. There was a significant increase in OPR per embryo transfer with the use of PGT-A in the subgroup of women aged 35–40 years who had two or more embryos that could be biopsied, but this was not significant when analyzed by ITT.
Cytokines hold promise for human embryo culture in vitro: results of a randomized clinical trial
Conclusion(s): Integration of cytokines into human embryo culture media showed improvement in embryological and clinical outcomes after ICSI. However, the long-term effect of cytokine enrichment of a medium is still unclear and warrants further studies with longitudinal follow-up
Embryonic aneuploidy rates are equivalent in natural cycles and gonadotropin-stimulated cycles
Result(s): Aneuploidy rates were equivalent in unstimulated and stimulated IVF cycles. The prevalence of aneuploidy in natural cycles increased with the age of the female partner in a manner identical to that seen in stimulated IVF cycles. Finally, sustained implantation rates of euploid blastocysts were equivalent in natural and stimulated IVF cycles.
The effect of sperm DNA fragmentation index on assisted reproductive technology outcomes and its relationship with semen parameters and lifestyle
Conclusions: As an increasingly common technique for reproductive testing, sperm DFI has proven to be very valuable in male fertility evaluation, but its significance as a predictor of pregnancy outcomes following ART requires further investigation.
Assisted reproductive technology treatment and risk of ovarian cancer—a nationwide population-based cohort study
WIDER IMPLICATIONS OF THE FINDINGS: Undergoing ART treatment without the presence of endometriosis was not associated with an increased risk of ovarian cancer, which is reassuring. Whether ART treatment increases the risk of ovarian cancer among women with endometriosis needs further investigation.
Baby Henry wouldn't have been born if it weren't for two couples. He was created by one, but grown and raised by another. Henry is the face of successful embryo donation.
The business of IVF: how human eggs went from simple cells to a valuable commodity
Globally, the industry is estimated to be worth US$25 billion and is predicted to grow to US$41 billion by 2026. But it’s easy to forget that before the business of IVF, human egg cells were just that — cells. Not an entity to be manipulated in the laboratory, not something to be bought or sold, not a valuable commodity that crosses international borders.
Fathering children by assisted reproduction linked to increased risk of prostate cancer
Men who became fathers through assisted reproduction techniques seem to be at higher risk for prostate cancer and early onset prostate cancer compared with men achieving fatherhood naturally.
Are aneuploidy rates in natural and stimulated cycles different?
Summary
In this USA Study, aneuploidy rates in natural and stimulated cycles were the same.
Comment
Aneuploidy (the presence of an abnormal number of chromosomes) is thought to be the main cause of unsuccessful implantation and of miscarriage. Many IVF cycles routinely test for aneuploidy in usable blastocysts to try and reduce the risk of failed pregnancy and increase the time to pregnancy by only transferring euploid embryo. While there remain some arguments over whether the testing of aneuploidy reduces the implantation potential, the high rates of aneuploidy is a powerful reason why it is offered to IVF clients using IVF. The question of why there are high rates in IVF is difficult to answer until this study from a private clinic in the USA. |Published in Fertility and Sterility, the authors tested the incidence and the implantation rate by age group in 369 women attempting IVF in a natural, unstimulated cycles. From 329 oocytes from 307 cases proceeding to oocyte recovery, 302 mature oocytes were recovered (92%), 275 fertilised and 147 developed to blastocysts. Following PGT-A, 83 (57%) were euploid !| Impressively, 79 proceeded to transfer leading to 56 pregnancies (71%) and 48 (61%) viable pregnancies with a fetal heart at 8 weeks. Compare this the clinics age matched date for stimulated cycles of 80% pregnancy rate ( +ve hCG, n=1657) and 63% viable pregnancy rate. |It is well recognized that the aneuploidy rate is a function of age, increasing from 25% in women less than 35 years of age rising about 80% form women over 40 years of age. When the authors compared the aneuplody rate for women in either natural or stimulated cycles and reported the rates were virtually identical. In other words, the high rates of chromosomal errors found in older women in stimulated cycles were also observed in women in a relative natural ovulatory cycle and that ovarian stimulation did not influence this rate. This is an important observation that answers critics of IVF that the stimulation is the main cause of the high aneuploidy rates overall and especially in older women. |In the discussion the authors reviewed past publications noting that early reports suggested a relationship because the rate was linked to higher doses of gonadotrophins. Later publications suggested otherwise when the rates were dissected by age. As is in this report, age is the key factor in whether the chromosomes separate correctly and meiosis (and later and both in men and women). It also thrusts very clearly, the implication of delaying conception. |The authors also noted that for logistical reasons, ovulation was induced by both hCG and a GnRH agonist so there remains a tiny caveat on these observations that ovarian stimulation does not increase the risk of aneuploidy. What was impressive was the viable pregnancy rate (the authors called this the sustained implantation rate or SIR) in natural IVF cycles. Even though there was some attrition in the number of women proceeding to transfer, for those who did achieve a frozen embryo transfer, the chance of pregnancy was as good (almost) as those who requested stimulation. Given the issue associated with surplus embryo storage and the cost in some countries of gonadotrophins, maybe more clinic could consider offering natural cycles to more clients. |
IVF Training - Questions relating to mailout links -
Open Challenge and complete Questions
Question
Type
Options
I agree that in certain circumstances, selecting an embryo with a deafness characteristic to match its potential parents is acceptable.
1
0
I agree that in certain circumstances, selecting an embryo with a deafness characteristic to match its potential parents is acceptable.
1
0
Overall, how did the aneuploidy rates compare between natural and stimulated cycles?
1
3
How were the aneuploidy rates effect by the age of the woman
1
3
After the transger of euploid frozen embryo(s), how did the ongoing pregnancy rate in natural cycles compare to those in stimulated cycles.
1
3
For women under 35 years of age, the aneuploidy rate was?
1
5
For women between 35 and 37 years of age, the aneuploidy rate was?
1
5
For Women Between 38 And 40 Years Of Age, The Aneuploidy Rate Was?
1
5
For Women Between 41 And 42 Years Of Age, The Aneuploidy Rate Was?
1
5
For Women more than 42 Years Of Age, The Aneuploidy Rate Was?
1
5
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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