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Preimplantation Genetic Testing for Aneuploidy Improves Clinical, Gestational, and Neonatal Outcomes in Advanced Maternal Age Patients Without Comprom
Conclusion: PGT-A improves clinical outcomes, particularly by reducing pregnancy loss and chromosomally abnormal pregnancy for patients of advanced maternal age, with no major impact on cumulative live-birth rate (CLBR) per egg retrieval.
Sperm Genomic Integrity by TUNEL Varies Throughout the Male Genital Tract
Conclusions: For the first time, we demonstrate that SCF increases progressively from the testicle, to the epididymis, vas deferens, and is highest in the ejaculate. Men with high ejaculated SCF can benefit from using SR sperm for IVF/ICSI
Simultaneous detection of two growth factors from human single-embryo culture medium by a bead-based digital microfluidic chip
Using the culture media of human embryos with normal morphologic features, we found that the concentrations of TNF-α: change little from day 3 to day 5–6, but the concentrations of IL-1β: for some embryos might double from day 3 to day 5–6. For other embryos even with similar normal morphologic features, some growth factors, such as IL-1β:, might exhibit different expressions during the culture period. Those growth factors could serve
Live birth outcomes of vitrified embryos generated under growth hormone stimulation are improved for women categorized as poor-prognosis
Conclusion. The embryos cryopreserved from fresh IVF cycles in which adjuvant GH had been administered to women classified as poor-prognosis showed a significant 2.7-fold higher LB rate in subsequent FET cycles than a matched poor-prognosis group. The women with a poor prognosis who were treated with GH had LB outcomes equivalent to those with a good prognosis. We therefore postulate that GH improves some aspect of oocyte quality that confers imp
Does dysbiotic endometrium affect blastocyst implantation in IVF patients?
Conclusion: Analyzing microbiota at the species-level resolution may be necessary for identifying the true pathogenic bacteria of the endometrium and avoiding over-intervention against non-Lactobacillus microbiota. Further studies are necessary for analyzing the mechanism of how the pathogenic bacteria affect embryo implantation.
Transient Sperm Starvation Improves the Outcome of Assisted Reproductive Technologies
In this work, sperm were incubated in the absence of exogenous nutrients (starved) until they were no longer able to move. Once immotile, energy substrates were added back to the media and sperm motility was rescued. Following rescue, a significantly higher percentage of starved sperm attained hyperactivated motility and displayed increased ability to fertilize in vitro when compared with sperm persistently incubated in standard capacitation medi
Human Egg Maturity Assessment and Its Clinical Application
Noninvasive spindle imaging using polarized light microscopy (PLM) allows quick and easy inspection of whether the PB-displaying oocyte actually reassembled a meiotic spindle prior to ICSI. Here, we present a standard protocol to perform human egg maturity assessment in the clinical laboratory. We also show how to optimize the time of ICSI with respect to the oocyte's developmental stage in order to prevent premature sperm injection of late-matu
Egg maturity assessment prior to ICSI prevents premature fertilization of late-maturing oocytes
Conclusions: The study confirms the prognostic value of spindle imaging and demonstrates that immature oocytes can be clinically utilized and give rise to live births when the timing of ICSI is adjusted to their developmental stage.
Single woman in Poland? Your embryos could be given to another couple
Under Polish law, her embryos could one day be given to a married couple she has never met, without her permission. Because Barbara is separated from her husband, as a single woman, she is now treated as an "anonymous donor" under a law passed in Poland in 2015.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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