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Single Molecule Sequencing A New Approach for Preimplantation Testing and Noninvasive Prenatal Diagnosis Confirmation of Fetal Genotype
hese findings provide proof of concept that NGS has clinical utility as a safe and effective PGT-M methodology for embryo genotyping as well as more complex direct HLA matching. Additionally, NGS can be used to confirm the original PGT-M and HLA matching embryo results in early pregnancy without the need for invasive prenatal diagnosis.
Increasing paternal age and ejaculatory abstinence length negatively influence the intracytoplasmic sperm injection outcomes from egg‐:sharing do
Discussion and Conclusion: Additional tracking of the influence of male characteristics on ICSI outcomes should be stimulated. Paternal age is not manageable, but reducing EA could be an alternative approach to improve the outcomes of ICSI.
Development and evaluation of inexpensive automated deep learning-based imaging systems for embryology†
Using a layered learning approach, we have shown that network models pre-trained with high quality embryo image data can be re-trained using data recorded on such low-cost, portable optical systems for embryo assessment and classification when relatively low-resolution image data are used. Using two test sets of 272 and 319 embryo images recorded on the reported stand-alone and smartphone optical systems, we were able to classify embryos based on
Screening Human Embryos for Polygenic Traits Has Limited Utility
The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability.
Clinical utility of freeze-all approach in ART treatment: A mini-review
Nonetheless, current evidence based on randomized controlled trials and observational studies indicates that FA might be justified in selected clinical scenarios, such as those involving the risk of OHSS. By contrast, there is a lack of evidence to support the FA policy for other indications, such as implantation failure or high progesterone levels on the trigger day. This review summarizes the clinical effectiveness of FA with the main focus on
The motility-based swim-up technique separates bull sperm based on differences in metabolic rates and tail length
Our study confirms that the upper fraction of bull sperm has not only improved motility compared to the cells in the lower fraction but also shows higher metabolic rates and longer flagella. This pattern was consistent across media of two different levels of viscosity. We conclude that the motility-based separation of the swim-up technique is also reflected in underlying metabolic differences. Metabolic assays could serve as additional or altern
Biologists examine sperm quality on the basis of their metabolism
Every tenth couple worldwide is affected by infertility. The reasons for this are manifold, but mostly well researched. Nevertheless, about fifteen percent of cases remain unexplained. A team of biologists has now gained new insights into the metabolic properties that make up a good sperm cell.
Simulations suggest embryo selection based on traits like height or IQ is still far off
The recent live births resulting from human embryonic CRISPR editing have heightened global concerns regarding 'designer babies.' Currently, the most practical approach to genetic 'enhancement' is preimplantation genetic screening of IVF embryos. The ability to select for traits that are brought about by multiple genes - rather than genetic diseases caused by a single mutation - is more far off and complicated than most people realize.
Controversial DNA screening technique used for at least one pregnancy
A company called Genomic Prediction has confirmed that at least one woman is pregnant with embryos selected after analysing hundreds of thousands of DNA variants to assess the risk of disease. It is the first time this approach has been used for screening IVF embryos, but some don’t think this use of the technology is justified.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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