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Frozen embryo transfer: evidence-based markers for successful endometrial preparation
Endometrial receptivity appears to be as important as chromosomal normality in determining embryo implantation and pregnancy outcome, because the ongoing pregnancy rate with transfer of preimplantation genetic testing for aneuploidy euploid blastocysts is ∼:50%. This Views and Reviews article focuses on our current knowledge of the biology of endometrial receptivity and on the role of both invasive (endometrial biopsy) and noninvasive (ultra
COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management
We herein propose remedies that include a prognostic-stratification of more vulnerable infertility cases in order to plan a progressive restart of worldwide fertility treatments. At a time when preventing complications and limiting burdens for national health systems represent relevant issues, our viewpoint might help competent authorities and health care providers to identify patients who should be prioritized for the continuation of fertility c
Sperm count affects cumulative birth rate of assisted reproduction cycles in relation to ovarian response
Higher TSC values have a positive impact on cumulative success rates in cycles characterised by few retrieved oocytes (1 to 5), while does not influence the outcome of cycles with a normal (6 to 10) or high (> 10) number of retrieved oocytes.
Detection of IL-6, IL-10, and TNF-α: level in human single-blastocyst conditioned medium using ultrasensitive Single Molecule Array platform and i
Conclusion. IL-6 concentration in SBCM was associated with embryo quality depending on the blastulation time, although it might not be associated with the blastocyst implantation.
The effect of insemination methods on in vitro maturation outcomes
There was a comparable yield of in vitro matured oocytes derived from PCOS patients in terms of fertilization, blastocyst formation, implantation rate, and clinical pregnancy between IVF and ICSI insemination. These findings provide valuable insights for choosing assisted reproductive treatment in women with PCOS, as IVM offers promising outcomes and is less invasive and less costly.
Association between endometrial thickness and neonatal outcomes in intrauterine insemination cycles: a retrospective analysis of 1,016 live-born singl
Conclusions: EMT is not independently associated with adverse perinatal outcomes in IUI cycles. This novel finding would provide reassuring information for IUI patients with thin endometrial linings regarding their neonatal health. However, further prospective cohort studies with larger datasets are needed to confirm the conclusion.
MicroRNAs in Small Extracellular Vesicles Indicate Successful Embryo Implantation during Early Pregnancy [Mouse]
In conclusion, these findings suggest that the endometrium derived-sEV miRNAs are potential biomarkers in determining the appropriate period for embryo implantation. This study also has several important implications for future practice, including therapy of infertility.
GM-CSF does not rescue poor-quality embryos: secondary analysis of a randomized controlled trial
Conclusion: This exploratory analysis is consistent with GM-CSF protecting morphologically normal embryos from culture-induced stress and does not support an effect of GM-CSF in rescuing poor-quality embryos.
Is cell-free DNA in spent embryo culture medium an alternative to embryo biopsy for preimplantation genetic testing? a systematic review.
Spent culture medium (SCM) represents a possible source of embryonic DNA for non-invasive preimplantation genetic testing (PGT). Before considering routine clinical use, methodologies need to be improved to increase detection of embryo DNA in SCM while preventing contamination by exogenous and maternal DNA. The identification of DNA origin (in particular, maternal versus embryonic) is necessary for improved reliability of SCM–PGT
POSEIDON Criteria may provide a tool to reintroduce ART services.
Comment
The authors recognise that the shutdown of clinical services including ART services is an essential response to the COVID crisis but there are some services in ART that carry a risk for IVF clients who cannot afford a long down time. The issue for these clients is their age and decreasing reproductive prospects. The issue clinics may face when they are allowed to resume services is how to reintroduce services that maintain social distancing and minimize infection risk to staff and clients. |The authors suggest using the POSEIDON criteria to assist how a clinic may reintroduce individualized services to each couple. POSEIDEON is a criteria based on each females age and endocrinology assessment coupled with any previous ART experience. |The authors highlight the problem with age with the statistic of the number of oocytes required to confidentially deliver one euploid embryo for transfer.|
Five oocytes produce one euploid embryo for women aged 33.|
Six oocytes produce one euploid embryo for women aged 34.|
Thirteen oocytes produce one euploid embryo for women aged 38.|
Sixteen oocytes produce one euploid embryo for women aged 39.|
Nineteen oocytes produce one euploid embryo for women aged 40.|
The data indicates that delaying treatment will reduce reproductive outcomes.||
The authors also outline other clients who need fertility preservation (i.e. ovarian stimulation and oocyte/embryo cryopreservation). These include clients with cancer or other conditions such as autoimmune disorders) and young women with a risk of premature menopause (POSEIDON category 3).|
The authors also include men with cancer or diminished semen quality.|
Furthermore, the risk to the pregnancy remains unclear at this time and the authors point out that as better tests become available, further discussions will be needed in risks associated with treating couples who have had the infection.
The authors point out that the above cases represent a small group of clients where delay of treatment may have long term consequences but will not create a burden on health systems.|
Conclusions (quote)|
“This article provides a viewpoint to help both competent authorities and health care providers to better identify priorities and remedies for infertile patients impacted by the COVID-19 pandemic restrictions. In a moment when preventing complications and limiting burdens for national health systems could still represent a relevant issue, the correct prognostic stratification of patients and the identification of more “time-sensitive” cases is crucial for guiding the gradual restart of ART services.”|
IVFLabOnline - Recent Enteries to IVFLabOnlines product listings.see IVFLabonline
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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