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Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization
In conclusion, the microinjection of spermatozoa into oocytes does not appear to have an impact on subsequent metabolism and viability. Observed differences in amino acid metabolism may be attributed to male factor infertility of the patients rather than the ICSI procedure per se.
The influence of oxygen concentration during embryo culture on obstetric and neonatal outcomes: a secondary analysis of a randomized controlled trial
The present data show that, at least in egg donation cycles undergoing Day 3 embryo transfers, culturing embryos under atmospheric oxygen concentration seems not to affect perinatal outcomes.
Fallopian tube epithelial cells express androgen receptor and have a distinct hormonal responsiveness when compared with endometrial epithelium
Proliferative indices, hormone receptor expression-scores and in vitro response to oestrogen and androgens of the human fallopian tube (FT) epithelium demonstrate a distinct pattern from the matched endometrium.
Exposure of human fallopian tube epithelium to elevated testosterone re
How does exposure to a testosterone rich environment affect the function and gene expression of human fallopian tube epithelium (hFTE)? SUMMARY ANSWER. Elevated testosterone level alters several gene transcripts that regulate cilia expression and negatively impacts the rate of cilia beating.
Measuring IGF-1 and IGFBP-3 Profiles in Women Seeking Assisted Reproduction: Relationship to Clinical Parameters (Study 1)
The study shows a significant linear reduction in IGF-1 levels across the four age groups (<35 years, 35-39 years, 40-44 years and ≥:45 years: p < 0.001). However, there was no variation in IGFBP-3 levels but the IGF Ratio showed a progressive linear elevation with advancing age (p < 0.001). With respect to both BMI and stature, none of the IGF profile parameters showed any variation.
Effect of newborn gender on placental histopathology and perinatal outcome in singleton live births following IVF
Conclusions: Newborn gender has a significant impact on the placental histopathology pattern, which can contribute to the development of adverse perinatal outcomes.
Initial serum HCG levels are higher in pregnant women with a male fetus after fresh or frozen single blastocyst transfer: A retrospective cohort study
Conclusions: MsHCG levels are higher in pregnant women with a male fetus than those with a female one on day 11 after fresh or frozen SBT. A sex-specific response to the stress in the process of in vitro embryo culture was suggested.
The reproducibility of trophectoderm biopsies - The chaos behind preimplantation genetic testing for aneuploidy
Chromosomal mosaicism is a common feature of early human embryos development. Presented data clearly demonstrate the limitations and shortages of the preimplantation genetic testing for aneuploidy screening test, which are not in alignment with WHO basic requirements.
The reproducibility of trophectoderm biopsies in euploid, aneuploid, and mosaic embryos using independently verified next-generation sequencing (NGS):
TE biopsies predict euploidy or aneuploidy in the ICM with a high degree of accuracy. PGT-A with NGS of TE biopsies is shown to be highly reliable, with clinically relevant concordance rates for aneuploidy and euploidy over 95%.
Degenerated oocyte in the cohort adversely affects IVF outcome
Fertilization rate, pregnancy and clinical pregnancy rates were comparable between the two groups, however, the morphokinetics and developmental scores of the embryos were significantly worse in the DEG group.
The fallopian tube epithelial and cilia are different to endomtrial epithelial.
Comment
Two recent, open access studies published by Human Reproduction in 2020 explored the response of fallopian tube epithelial (FTE) to endocrine stimulation. Together they provide some small insights into their function. |
The first by A Maclean, et.al explored the difference in hormone receptors between the tubal and the endometrial environment. They reported that unlike the endometrium, tubal epithelium does not undergo the same cyclicity. The distribution of E2 and P4 receptors was largely similar between the fimbrial or isthmic ends. Importantly, androgen activity via the androgen receptor largely damped the activity of the E2 receptor making the tubal epithelial somewhat quiescent. |
The other paper by Tia Jackson-Bey, et al. explored fallopian cilia activity under endocrine influence. They were exploring the effect of testosterone on cilia activity with a view to understanding the impact of PCOS. They reported that cilia activity was significantly dampened under androgen exposure. Androgen activity peaks around ovulation and they suggest such ovarian derived may act to reduce cilia beating frequency. |
Together the 2 papers provide evidence that the tubal epithelium is both different and similar to endometrial epithelium. It appears that while expressing similar endocrine receptors, they do not behave in a similar manner. Importantly, androgen activity appears to quell estrogen receptor function and dampen cilia activity. |
Title
The presence of degenerated oocytes means the quality of embryos in the cohort was compromised
Summary
In a retrospective study exploring the impact of degenerated oocytes, the authors reported diminished embryo development but no impact on pregnancy rates.
Comment
In a retrospective analysis of data by an Israeli clinic, 81/399 cycles (or 20%) had at least one degenerated oocyte. They showed that even though the fertilization rate and the pregnancy rate was the same in cycles with or without damaged oocytes, the morphokinetic data from time lapse incubators revealed that the KID scores were significantly lower (3.4 x 32) as was the number of top-quality embryos. |
In a multivariate analysis, they argued that thinner needles were linked to more degenerated oocytes. Moreover, the more degenerated oocytes observed, the poorer the pregnancy rate. |
This study shows that the presence of degenerated oocytes on a cohort of recovered oocytes may be marker of physical stress during the oocyte collections. The stress may include the vacuum pressure or the degree of curetting or flushing of the follicle and even though only a few oocytes are physically ruptured, all the oocytes had under gone some degree of stress. Even though the pregnancy rate between clients with and without damage was the same, all it demonstrated is that the best embryo can recover. |
The incidence of degenerated oocytes was higher with a 20-17G aspiration needle compared to a 17G needle and that more damaged oocytes was correlated with the use of GnRH antagonist protocol. |
Not all laboratory management systems will record the number of damaged oocytes or empty zona pellucida but they should. It would not be unreasonable to consider using the degeneration rate as a KPI and check this rate by clinicians to ensure the technique used at recovery was acceptable. This study has shown that the presence of degenerated oocytes indicated stress at collection and this stress can manifest itself in poor embryo quality and fewer top quality embryos. One could anticipate that fewer embryos may be available to freeze and the cumulative chance of pregnancy diminished. |
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In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
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