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Adjunct low-molecular-weight heparin to improve live birth rate after recurrent implantation failure: a systematic review and meta-analysis
In women with ≥:3 RIF, the use of adjunct LMWH significantly improves LBR by 79% compared with the control group: however, this is to be considered with caution, since the overall number of participants in the studies was small. Further evidence from adequately powered multi-centered RCTs is required prior to recommending LMWH for routine clinical use. This review highlights the need for future basic science and clinical research in this imp
Time of insemination culture and outcomes of in vitro fertilization: a systematic review and meta-analysis
Reduced gamete exposure time may be associated with beneficial outcomes. Drawbacks inherent to the quality of several studies limit the quality of the available evidence. Adequately powered randomized controlled studies need to be performed to evaluate the efficacy of brief insemination.
BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis
Overweight and obesity were associated with an increased prevalence of azoospermia or oligozoospermia. The main limitation of this report is that studied populations varied, with men recruited from both the general population and infertile couples. Whether weight normalization could improve sperm parameters should be evaluated further.
Effects of caloric intake timing on insulin resistance and hyperandrogenism in lean women with polycystic ovary syndrome
Two features of the PCOS, insulin resistance and increased ovarian cytochrome P450c17α: activity, can be attenuated by the timing of meals.
In lean PCOS women, a high caloric intake at breakfast with reduced intake at dinner results in improved insulin sensitivity indices and reduced cytochrome P450c17α: activity, which ameliorates hyperandrogenism and improves ovulation rate. Meal timing directed at lowering insulin secretion in lean wo
The assisted reproductive technology laboratory: toward evidence-based practice?
Despite these improvements, current ART laboratories are to a large extent composed of general laboratory equipment that is not designed and manufactured especially for human ART. Human reproductive cells have different physiochemical requirements than somatic cells. We encourage the development of laboratory equipment, utensils, and consumables that are designed specifically for human ART. In addition, the quality and consistency of commerciall
What do reproductive-age women who undergo oocyte cryopreservation think about the process as a means to preserve fertility
Surveying oocyte cryopreservation patients provides a glimpse into the knowledge base and motivations surrounding current female reproductive practices. Oocyte cryopreservation technology may prove to bridge the gap between reproductive prime and when a woman is realistically “ready” to have children.
Multidrug-resistant transport activity protects oocytes from chemotherapeutic agents and changes during oocyte maturation
Oocytes have a vast repertoire of active MDRs. The implications of this study are that these protective mechanisms are important during oogenesis and that these activities change with maturation, increasing susceptibility to toxicants. Future directions may exploit the up-regulation of these transporters during gonadotoxic therapy.
Using the ovarian sensitivity index to define poor, normal, and high response after controlled ovarian hyperstimulation in the long gonadotropin-relea
The OSI improves the definition of ovarian response patterns because it takes into account the degree of stimulation. The nomogram presents evidence-based cutoff levels for poor, normal, and high response and could be used for unifying study designs involving ovarian response patterns.
Fertility drugs and endometrial cancer risk: results from an extended follow-up of a large infertility cohort
Although we found no support for a relationship between fertility drugs and endometrial cancer risk, the association should continue to be monitored given that our study population was still young and had not yet reached the age of peak endometrial cancer incidence.
The success of assisted reproduction technologies in relation to composition of the total regulatory T cell (Treg) pool and different Treg subsets
Our findings suggest that Tregs, especially the naïve CD45RA+-Treg subset, may play a role in determining the probability of both becoming pregnant and maintenance of the pregnancy.
The centriolar satellite protein SSX2IP promotes centrosome maturation
In rapidly dividing blastomeres of medaka (Oryzias latipes) and in somatic cells, SSX2IP knockdown caused fragmentation of pericentriolar material and chromosome segregation errors. We characterize SSX2IP as a novel centrosome maturation and maintenance factor that is expressed at the onset of vertebrate development. It preserves centrosome integrity and faithful mitosis during the rapid cleavage division of blastomeres and in somatic cells.
Epidemiologic concerns relative to in vivo and in vitro production of livestock embryos
However, regardless of donor species, investigations involving collection of embryos from artificially or naturally infected animals and assessment of health of recipients and offspring after transfer of these embryos have indicated low potential for transmitting disease.
Children of obese mothers 'have higher heart risk'
Children born to obese and overweight mothers are more likely to die early of heart disease, a study has found. Scottish research showed a 35% higher risk of dying before the age of 55 in adults whose mothers were obese in pregnancy.
Couples in Scotland who need help conceiving will be guaranteed two free infertility treatments from 1 July. The new IVF criteria has been approved by the Scottish government, but there will be restrictions.
Meal Timing Can Significantly Improve Fertility in Women With Polycystic Ovaries
Polycystic Ovarian Syndrome (PCOS), a common disorder that impairs fertility by impacting menstruation, ovulation, hormones, and more, is closely related to insulin levels. Women with the disorder are typically "insulin resistant" - their bodies produce an overabundance of insulin to deliver glucose from the blood into the muscles. The excess makes its way to the ovaries, where it stimulates the production of testosterone, thereby impairing ferti
Inducing and Augmenting Labor May Be Associated With Increased Risk of Autism
regnant women whose labors are induced or augmented may have an increased risk of bearing children with autism, especially if the baby is male, according to a large, retrospective analysis by researchers at Duke Medicine and the University of Michigan.
Australian scientists to investigate genetic link to male infertility
Australian researchers may be a step closer to working out one of the causes of male infertility. The Western Australian Institute for Medical Research and Monash University have conducted a study on mice that did not have a gene called SLIRP and found that they had 30 per cent fewer offspring than normal mice.
How 'Teamwork' Between Egg and Sperm Works: Little-Known Protein Identified in Vertebrate Fertilization Process
Researchers from Heidelberg have decoded a previously unknown molecular mechanism in the fertilisation process of vertebrates. The team of scientists at the Center for Molecular Biology of Heidelberg University identified a specific protein in frog egg extracts that the male basal bodies need, but that is produced only by the reproductive cells of the female. This "teamwork" between the egg and sperm is what makes embryo development possible.
Children of Obese Mothers at Greater Risk of Early Heart Death as Adults
Children of obese and overweight women have a higher risk of early cardiovascular death as adults, finds a new study. The findings highlight the urgent need for strategies to prevent obesity in women of childbearing age and the need to assess the offspring of obese mothers for their cardiovascular risk, say the authors.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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