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Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to
Blastocysts that implanted released factors that differentially altered mRNA levels for six genes (>1.5 fold) compared with blastocysts that did not implant. A cohort of genes was validated at the protein level: SPARC and Jagged1 were down-regulated (P < 0.01), while SNAI2 and TGF-B1 were up-regulated (P < 0.05) by implanted compared with non-implanted BCM. Jagged-1 (P < 0.05) and Snai-2 protein (P < 0.01) showed cyclical changes in the endometri
Low-dose hCG supplementation after GnRH agonist triggering: don't be too quick on the trigger
When used alone (or with steroid-only luteal support) GnRH agonist triggering is undoubtedly the most efficient and powerful way of (secondary) OHSS prevention. So far there is no confirmed OHSS case in the literature that proves the opposite (Kol and Humaidan, 2012). This prevention occurs due to a massive, rapid and irreversible luteolysis leading to a practical, total elimination of clinically significant moderate/severe OHSS (Kol, 2004).
Severe early ovarian hyperstimulation syndrome following GnRH agonist trigger with the addition of 1500 IU hCG
Although the GnRH agonist plus 1500 IU hCG luteal rescue protocol significantly decreases the risk of severe OHSS, this life threatening complication can still occur in high-risk patients. It would be prudent to avoid hCG luteal rescue and freeze all embryos for future transfer in such women particularly when there are ≥:18 follicles with 10–14 mm diameters even with few larger follicles.
Motile sperm organelle morphology examination (MSOME) and sperm head vacuoles: state of the art in 2013
The high-magnification system appears to be a powerful method to improve our understanding of human spermatozoa. However, its clinical use remains unclear in the fields of male infertility diagnosis and assisted reproduction techniques (ARTs).
What is the optimal means of preparing the endometrium in frozen–thawed embryo transfer cycles? A systematic review and meta-analysis
Based on the current literature it is not possible to identify one method of endometrium preparation in FET as being more effective than another. Therefore, all of the current methods of endometrial preparation appear to be equally successful in terms of ongoing pregnancy rate.
The determination of reproductive safety in men during and after cancer treatment
Fertility-related concerns are frequently encountered in the course of providing care to oncologic patients. Male cancer survivors who desire paternity after cancer treatment face the question of whether their posttherapy sperm can be safely used in either natural or assisted conception attempts. Although the reproductive risks of using sperm genetically compromised by chemotherapy or radiotherapy include impaired embryonal development, pregnancy
Dual trigger with combination of gonadotropin-releasing hormone agonist and human chorionic gonadotropin significantly improves the live-birth rate fo
Dual trigger of final oocyte maturation with a GnRH-agonist and a standard dosage of hCG in normal responders statistically significantly improves implantation, clinical pregnancy, and live-birth rates in GnRH-antagonist IVF cycles
Fresh semen quality in ejaculates produced by nocturnal emission in men with idiopathic anejaculation
This study is the first to report on the quality of fresh semen obtained by NE in patients with idiopathic anejaculation. Sperm motility and normal morphology were higher in patients who collected sperm by NE than in those who collected sperm by PVS and EEJ.
In-vitro model systems for the study of human embryo–endometrium interactions
Implantation requires highly orchestrated interactions between the developing embryo and maternal endometrium. The association between abnormal implantation and reproductive failure is evident, both in normal pregnancy and in assisted reproduction patients. Failure of implantation is the pregnancy rate-limiting step in assisted reproduction, but, as yet, empirical interventions have largely failed to address this problem
Thin endometrium in donor oocyte recipients: enigma or obstacle for implantation?
No statistically significant difference was found in clinical pregnancy rates and live birth rates in cycles with endometrial thickness <6 mm compared with those with thickness >6 mm. A relatively high rate of live births was found within a medium range of endometrial thickness (9.1–10 mm).
IVF Fails to Improve Pregnancy Odds After 5 Cycles, Study Says
IVF is unlikely to be successful for any woman regardless of age after five failed rounds, researchers in Australia found in the first national study of pregnancy rates from in vitro fertilization. The chance of delivering a live baby over the first five cycles reaches 40 percent for women of all ages and about 50 percent for women younger than 35, a study by the University of New South Wales’s National Perinatal Epidemiology and Statistics Unit
Three-year effort sees miracle baby for Carly and Matthew Myers
A TEAM of geneticists and fertility specialists have helped turn tragedy into the most heart-warming joy for Carly and Matthew Myers. A three-year, Australian-first effort has allowed the short-statured couple to give birth to Lucinda in perfect health and free of a killer genetic mutation
The chance of getting pregnant using IVF could depend on what clinic you are using, new statistics show. The percentage of IVF cycles that lead to a baby being born is up to eight times higher in some clinics than others, according to figures from the National Perinatal Epidemiology and Statistics Unit at the University of NSW.
Adelaide Zoo set to use IVF to help giant pandas breed
ADELAIDE Zoo looks set to follow the lead of its counterparts in Washington and Taiwan and use IVF to help produce a giant panda cub. Zookeepers are still waiting for giant panda Funi's 36-hour fertility window to open, but are hopeful warmer weather predicted for the last half of the week helps get her in the mood to mate with partner Wang Wang .
Fertility treatments in Lebanon regular but unregulated
BEIRUT: Problems conceiving a child may never be discussed outside the doctor’s office in Lebanon, but the volume of fertility clinics shows that there’s definitely a demand for such treatment, local fertility specialists say. But without a national law addressing this field of medicine, ethical and legal dilemmas – like gender selection and regulating sperm and egg donation – are left up to the physicians’ and patients’ disposal.
BIOLOGICAL CLOCK:Women have been advised to start families by the age of 37, as fertility treatment for those over the age of 40 can be challenging.Women are being advised to plan early if they want to have children, as the number and quality of a woman’s ova start to diminish rapidly from the age of 37. Taiwanese Society of Reproductive Medicine president Huang Hong-yuan (黃:泓:淵:) yesterday said according to the Health Promotion
Australian couples travel overseas to avoid ban on choosing their baby's sex
Data suggests hundreds of Australian couples are travelling overseas to undergo IVF treatment that allows them to select the sex of their children.
A new study found around 120 couples attended a single IVF unit in Thailand over an 18-month period, to avoid Australia's regulatory ban on social sex selection.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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