Comment:Articles on time lapse embryo development and on male reproductive health.
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Micronutrients intake is associated with improved sperm DNA quality in older men
Men with higher dietary and supplement intake of certain micronutrients may produce sperm with less DNA damage, especially among older men. This raises the broader question of how lifestyle factors, including higher intakes of antioxidants and micronutrients, might protect somatic as well as germ cells against age-associated genomic damage.
Effect of seminal plasma application to the vaginal vault in in vitro fertilization or intracytoplasmic sperm injection treatment cycles—a double-blin
Patients who underwent SP intravaginal insemination after oocyte pick-up reached higher implantation and clinical pregnancy rates following ET compared to controls, although the difference did not reach statistical significance. More studies and variable methodologies may clarify the potential clinical effect of SP in improving live birth rates after ART.
Paternal Diet-Induced Obesity Retards Early Mouse Embryo Development, Mitochondrial Activity and Pregnancy Health
Taken together, these data clearly demonstrate that paternal obesity has significant negative effects on the embryo at a variety of key early developmental stages, resulting in delayed development, reduced placental size and smaller offspring.
One abstinence day decreases sperm DNA fragmentation in 90 % of selected patients
Four hundred and sixteen patients produced a first semen sample after a sexual abstinence of 3 to 7 days. Sperm DNA fragmentation was altered in 46 samples (11.1 %). Thirty five patients with increased DNA fragmentation samples completed the “one abstinence day protocol”. DNA fragmentation decreased to normal values in one of the three attempts in 91.4 % of the patients: 81.3 % in the first attempt, 12.5 % in the second try and 6.3 % in the third
Could time-lapse embryo imaging reduce the need for biopsy and PGS?
With continued effort, the combination of multiple morphologic endpoint assessments and developmental timings and refinement of modeling systems may improve the predictive ability to determine embryonic aneuploidy. This may help select a subset of embryos that are less likely to carry chromosomal abnormalities and improve assisted reproductive outcomes. However, embryo biopsy, followed by preimplantation genetic screening/comprehensive chromosoma
Advances in quality control: mouse embryo morphokinetics are sensitive markers of in vitro stress
MKs in mouse embryos are a sensitive and efficient method for quality control testing of in vitro culture conditions. BR, the end-point of traditional quality control assays, did not detect sublethal concentrations of toxins in the culture milieu in our study. This study demonstrates that temporal variation at key developmental stages reflects the quality of the culture environment. An MEA that incorporates MK will provide enhanced sensitivity an
The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture
The PN morphology changes over time, indicating that the single light microscopy observation approach is deficient in comparison to time-lapse. Although the assessment of the PN morphology does not improve embryo selection, the timing of PNB should be included in embryo selection parameters.
Similar morphokinetic patterns in embryos derived from obese and normoweight infertile women: a time-lapse study
Embryos from obese and normoweight infertile women showed similar cleavage patterns, but occurring more slowly, to those from fertile donors. These differences were statistically significant for t2 (time of cleavage to two-blastomere embryo) (P = 0.016), t3 (P = 0.014), t4 (P = 0.003) and t5 (P = 0.040).
Time-lapse parameters as predictors of blastocyst development and pregnancy outcome in embryos from good prognosis patients: a prospective cohort stud
Our results in context with the lack of consistency in previous studies and the presumed influences of different external factors indicate that a universal algorithm for optimal timing of development might not be feasible. The apparent negative significance of division patterns that differ from the expected may imply that time-lapse will facilitate de-selection of embryos
Human embryonic development after blastomere removal: a time-lapse analysis
CONCLUSIONS We find that blastomere biopsy prolongs the biopsied cell-stage, possibly caused by a delayed compaction and alters the mechanism of hatching.
Maternal Fructose and/or Salt Intake and Reproductive Outcome in the Rat: Effects on Growth, Fertility, Sex Ratio, and Birth Order
We demonstrate that excess fructose consumption before and during pregnancy led to a marked skew in the secondary sex ratio (proportion males, 0.60: P < 0.006). The effect was not mediated by selective developmental arrest of female embryos, or influenced by fetal position in the uterine horn or sex-specific effects on sperm motility, suggesting a direct effect of glycolysable monosaccharides on the maternal ovary and/or ovulated oocyte.
Time-lapse monitoring as a tool for clinical embryo assessment
Due to lack of larger, randomized clinical studies it remains to be elucidated whether embryo selection using dynamic parameters improves clinical outcome and which parameters are of significance. Before such randomized controlled studies are organized, the most promising parameters to evaluate must be identified. This mini-review summarizes the current knowledge about dynamic markers of viability and discusses the potential clinical role of time
Identification of Potential Oviductal Factors Responsible of the Zona Pellucida Hardening and Monospermy During Fertilization in Mammals
Oviduct fluid increases the time required for digestion of the zona pellucida (ZP) by protelolytic enzymes (ZP hardening). This effect has been associated to the levels of monospermy after fertilization in vitro (IVF) in the pig and cow but the possible existence of a directly proportional relation between hardening and monospermy remains unknown.
Dairy food intake in relation to semen quality and reproductive hormone levels among physically active young men
Further research is needed to prove a causal link between a high consumption of full-fat dairy foods and detrimental effects on semen quality. If verified our findings would mean that intake of full-fat dairy foods should be considered in attempts to explain secular trends in semen quality and that men trying to have children should restrict their intake.
Bovine Cumulus Cells Protect Maturing Oocytes from Increased Fatty Acid Levels by Massive Intracellular Lipid Storage
In conclusion these data suggest that short-term elevated free fatty acid concentrations in follicular fluid do not harm oocyte developmental competence. We propose that the involvement of high levels of mobilized oleic acid in follicular fluid in combination with the induced lipid storage in cumulus cells serves to prevent harmful saturated fatty acid exposure to the oocyte.
Surrogacy law to be challenged in court (South Africa)
Cape Town - A Cape Town woman is contesting current laws around surrogacy that require there be a genetic link with a parent, the Sunday Times reported.
Medical breakthrough gives cancer survivors hope of pregnancy
Australian doctors have achieved the world's first pregnancy from ovarian tissue grown outside the pelvis. Melbourne mother-to-be, Vali, 23, is now 25 weeks pregnant with twins, after having both of her ovaries removed when she was being treated for cancer.
Blowing raspberries: year-old fertility study yields belated headlines
Two UK newspapers have proclaimed the fertility-boosting benefits of the raspberry, with NHS Choices branding the claims 'misleading'. The Daily Mail's piece sets out to explain 'how eating raspberries could increase your chances of being a father'. 'With sperm counts in the average British male falling by almost half in the past 60 years', the article says, 'experts have claimed raspberries maybe the saviour to help fathers-to-be'. The Daily Exp
UK woman conceives with dead husband’s sperm abroad
How does UK law work on post-death use of sperm? The rules in the UK are clear – there must be written (and signed) consent from the sperm provider allowing the post death use of his sperm in treatment. In this case, the man’s sperm was extracted surgically after he was already in a coma he never recovered from. His wife therefore did not have the written signed consent she needed for treatment to take place in the UK, although she maintained t
Introducing Genea Biomedx [This link may be from a sponsor]
e started life within a world leading fertility clinic known as Sydney IVF (now called Genea). For over 25 years, we’ve worked hand in hand with embryologists, andrologists, clinicians and nurses to create consistently better outcomes for clinics and their patients. As Genea Biomedx, we plan to make a big impact on the way things are done in fertility - by transforming our immense wealth of expertise into practical, accessible, precise technolog
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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