Comment:Lots of interesting links this week. Note the concern over time-lapse modelling and age, Jason Swains article on agitation in embryo culture and gender differences at the Zona Pellucida based upon Sperm DNA fragmentation. FertAid would like ask all authors to consider contributing a review of their work to IVFCPD modules. QAPonline 2014 subscriptions are now available.
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A cautionary note against embryo aneuploidy risk assessment using time-lapse imaging
We believe that the statements made in these articles, which include the proposed ability to increase pregnancy rates by determining embryo aneuploidy risk by time-lapse imaging, are premature and to this point unsubstantiated by the published data. We provide evidence from existing publications and from our own data that suggests that the statements recently made are misleading. We make the point that further investigation is needed either in t
Behaviour of cytoplasmic organelles and cytoskeleton during oocyte maturation
To better understand the mechanism underlying oocyte maturation and for the future improvement of assisted reproduction treatment, this review focuses on the complex processes of cytoplasmic organelles and the dynamic alterations of the cytoskeleton that occur during oocyte maturation. Ovarian stimulation and in-vitro maturation are the major techniques used in assisted reproduction treatment and their influence on the organelles of oocytes is al
Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature
Women undergoing assisted reproduction are often older, increasing the chances of obtaining abnormal gametes that may cause deviations in outcomes between assisted-conception and naturally conceived children. However, after taking into account these factors, it is not clear to what extent poorer outcomes are due to the assisted reproduction procedures themselves. Large-scale, multicentre, prospective epidemiological studies are needed to investig
Ovarian response markers lead to appropriate and effective use of corifollitropin alpha in assisted reproduction
Corifollitropin alpha is a highly effective gonadotrophin, which maintains multifollicular growth for a week. The advantages of its administration include ease of use of the drug, making the treatment more patient friendly, resulting in a lower level of distress for the patient. At the same time, the pregnancy rate resulting from its use in IVF/intracytoplasmic sperm injection cycles is similar to that found when daily recombinant FSH is adminis
Compartmentalization of Distinct cAMP Signaling Pathways in Mammalian Sperm
Fertilization competence is acquired in the female tract in a process known as capacitation. Capacitation is needed for the activation of motility (e.g. hyperactivation) and to prepare the sperm for an exocytotic process known as acrosome reaction. ->Altogether, these data suggest that cAMP pathways are compartmentalized in sperm, with Gs and tmAC in the head and Adcy10 and PKA in the flagellum
Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways
Sperm capacitation enables spermatozoa to undergo the acrosome reaction and to exhibit vigorous motility called hyperactivation. At the molecular level, capacitation is associated with activation of a cAMP-dependent pathway and with the increase of intracellular pH and Ca2+ concentrations. Ca2+ ionophore A23187 elevates intracellular Ca2+ and induces the acrosome reaction but renders the spermatozoa motionless.
Shake, rattle and roll: bringing a little rock to the IVF laboratory to improve embryo development
However, emerging dynamic culture platforms have demonstrated a benefit to embryos during the incubation period. These dynamic platforms result in gentle media disruption and embryo movement though tilting, vibration and media flow. Thus, in keeping with the theme of the title, one could say that a little “rock-and-roll” in the IVF lab may be beneficial to in vitro embryo development
Temperature variations within and between incubators—a prospective, observational study
Conclusion(s):We found temperatures differed within and between our front-loading incubators. Thus, laboratory personnel should evaluate their incubators for temperature variations within and between incubators and, if temperatures differ significantly, develop a plan to deal with discrepancies. [Ed Note: A good reason to explore the use of benchtop incubators with minimal free space]
Accu-Beads as a quality control measure for manual and automated methods of measuring sperm concentration—an observational study
Conclusion(s)
In our laboratory, Accu-Beads met enough of the requirements of a good control material to be acceptable for daily quality control use, especially if we set our own ranges of acceptability for each vial of Accu-Beads. It is necessary to evaluate each new lot of Accu-Beads when they are received and again if they are used with a different counting chamber.
Correlation between follicular diameters and flushing versus no flushing on oocyte maturity, fertilization rate and embryo quality
Conclusions: The results of this study shows that: a) Follicles larger than 18 mm at retrieval have consistently mature oocytes with a higher rate of fertilization: b) Small size follicles are still capable of containing mature oocytes, but their rate of abnormal or no fertilization is high: c) Oocytes recovered with flushing are still able to produce embryos with full developmental competence.
Nuclear DNA fragmentation negatively affects zona binding competence of Y bearing mouse spermatozoa
Conclusion(s): The zona pellucida may have a role in preventing DNA damaged mouse sperm binding especially towards Y-bearing sperm. However, the exact mechanism behind this observation needs to be elucidated further. [Ed Note: This needs to be repeated and confirmed]
In vitro development of human primordial follicles to preantral stage after vitrification
Conclusions:Vitrification of ovarian strips with an improved carrier device and culturing of follicles in ovarian strips after warming yielded developed follicles with high viability and morphological integrity that may be suitable for use in fertility preservation among cancer patients.
Single pre-screened embryo transfer offers better neonatal outcomes after IVF
Study Rundown: In this study, researchers found that IVF with a single, genetically pre-screened embryo resulted in similar delivery rates with fewer multiple births, preterm deliveries, and NICU admissions than with multiple embryo transfer. This study suggests that the addition of comprehensive chromosome screening to single embryo transfer can improve safety outcomes without altering success rates.
There are now a million babies born in the world who wouldn't be here if not for the miracles of IVF. But as Australian society changes, meeting the demands for fertility services is facing some new hurdles. There's a shortage of local sperm donors and in the case of one Adelaide based fertility clinic it's driven them overseas for answers
Physicist Pairs Up with Bioengineer to Help IVF Specialists Identify Healthiest Sperm
It’s an unlikely pairing – physicist Erkan Tuzel and Harvard Medical School bioengineer Utkan Demirci – but it is one that may very well change the face of in vitro fertilization (IVF) if their collaboration proves to be successful.
IVF Surprise for Ind. Couple Expecting 2nd Set of Triplets
An Indiana couple is expecting their second set of triplets – an IVF surprise they're still trying to wrap their heads around because they only had two embryos implanted. Sarah Imbierowicz and her husband Bill have four boys: 3-year-old Will and 15-month-old triplets Tommy, Sammy and Drew. And in two months, the Kokomo, Ind., couple will welcome three girls. [Ed Note: what a good example of recommending SET]
Single-Cell Genomics Could Improve IVF Screening-A method for single-cell DNA analysis could provide a safer genetic screen for IVF.
Fertility doctors in Beijing have begun testing a new method for genome analysis of human eggs before using them for in vitro fertilization or IVF. The tests, using technology developed by a Harvard chemist, allow doctors to know the genome of a woman’s egg before it is used in IVF, which could provide a safer way to help their patients avoid genetic disorders in children.
Reproductive Biologists Move in Vitro Fertilization Knowledge Forward
Two new papers from reproductive biologists at the University of Massachusetts Amherst, with international partners, report advances in understanding the basic processes of sperm capacitation that may one day improve success rates of in vitro fertilization (IVF) by providing a shortcut to bypass problems, and may eventually lead to a male contraceptive.
Obama admin’s FDA mulling three-parent embryo creation
While some European ethicists and politicians have called for an end to the creation of “three-parent” IVF embryos, the U.S. Food and Drug Administration has announced it is considering allowing the practice - without having held a public consultation. Researchers say that the technique “modifies standard IVF technology” to create an embryo from the eggs of two women and sperm from one man.
Global In Vitro Fertilization Market 2012-2016 [This link may be from a sponsor]
TechNavio's analysts forecast the Global In Vitro Fertilization (IVF) market to grow at a CAGR of 12.12 percent over the period 2012-2016. One of the key factors contributing to this market growth is the high prevalence of infertility rates. The Global IVF market has also been witnessing the increase in medical tourism. However, the high cost associated with the IVF procedures could pose a challenge to the growth of this market.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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