Comment:More on the debate on the predictability of time-lapse embryo monitoring.Plus an interesting article on the barcoding of oocytes and embryos (glimpse into the future?). Also QAPonline and IVFCPD subscriptions can now be bundled with some discounting.
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Reply: Time-lapse parameters could not predict pregnancy: a hasty conclusion?
Dr Thornhill expresses relevant concerns regarding the number of positive outcomes in the study. On the presumption of a type II error, he suggests that ‘time-lapse parameters could not predict pregnancy’ is a hasty conclusion. We entirely agree that both the number of positive outcomes and embryo transfers represent an important limitation to our study, which we believe is thoroughly acknowledged in the paper. In consistency, we desist from draw
Nuclear DNA fragmentation negatively affects zona binding competence of Y bearing mouse spermatozoa
Conclusion(s): The zona pellucida may have a role in preventing DNA damaged mouse sperm binding especially towards Y-bearing sperm. However, the exact mechanism behind this observation needs to be elucidated further. [Ed Note: This needs to be repeated and confirmed]
External validation of models and simple scoring systems to predict miscarriage in intrauterine pregnancies of uncertain viability
Both the model and the scoring system showed excellent performance on external validation confirming their generalizability and utility in prediction of viability beyond the first trimester in clinical practice. An advantage of the mathematical models original Mo and new Mn and scoring systems original SSo and new SSn is that they can provide women with an individualized probability of the viability of their pregnancy using only demographic info
Ranking and selection of MII oocytes in human ICSI cycles using gene expression levels from associated cumulus cells
Results presented in this study could be used to assist the selection of oocytes with high blastocyst developmental potential in frozen oocyte cycles and for the selection of embryos with high developmental potential as early as 18 h after ICSI (2PN stage) in fresh human IVF cycles.
Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death.
Both Cy and Doxo resulted in a significant increase in apoptotic follicle death in human ovarian xenografts compared with controls (62.0 ± 3.9% versus 25.7 ± 7.4%, P < 0.01 and 76.7 ± 7.4% versus 25.7 ± 7.4%, P < 0.01, respectively). This chemotherapy-induced apoptotic death was reduced both in the Cy+S1P (32.7 ± 4.4%, P < 0.01) and the Doxo+S1P group (27.1 ± 7.6%, P < 0.01) compared with Cy and Doxo groups, respectively.
Time-lapse parameters could not predict pregnancy: a hasty conclusion?
Kirkegaard et al.'s (2013) prospective study provides additional evidence that timing of early cleavage events can predict blastocyst development, first established using cryopreserved, donated embryos (Wong et al., 2010) and recently validated in a large-scale multi-center prospective study with 1233 embryos from 160 patients (Conaghan et al., 2013).
Barcode tagging of human oocytes and embryos to prevent mix-ups in assisted reproduction technologies
The direct embryo tagging system developed here provides fertility clinics with a novel tool to reduce the risk of mix-ups in human ARTs. The system can also be useful in research studies that require the individual identification of oocytes or embryos and their individual tracking.
It has been suggested that AMH should be considered a replacement for the ‘gold standard biomarker’ AFC (Usta and Oral, 2012: Nelson, 2013) based upon the contention that AFC is not sufficiently reliable due to variable skills of operators performing the baseline scans. Implicit in all the proposed attributes and uses for AMH, therefore, is the necessity of reliability and reproducibility of AMH detection.
Comparison of two models predicting IVF success: the effect of time trends on model performance
The changes in success rates over time should be taken into account when assessing prediction models for estimating the success rate of IVF treatment. In patients with primary infertility, the choice to use the Templeton or Nelson model is arbitrary.
Oocyte cryopreservation and in vitro culture affect calcium signalling during human fertilization
The relationship between a specific pattern of calcium oscillations and subsequent human embryonic development could not be evaluated since the calcium indicator used and the high-intensity excitation light impair development. Furthermore, all oocytes were derived from stimulated cycles and immature oocytes were denuded prior to in vitro maturation.
Time-lapse parameters as predictors of blastocyst development and pregnancy outcome in embryos from good prognosis patients: a prospective cohort stud
Duration of the first cytokinesis, duration of the 3-cell stage and direct cleavage to 3-cells predicted development to high-quality blastocyst. We found no difference in timing between implanted and non-implanted embryos.
Circulating insulin-like factor 3 (INSL3) in healthy and infertile women
we showed a phasic expression of INSL3 corresponding to antral follicle growth in both the follicular and luteal phases of the cycle, which was significantly (P < 0.05) elevated compared with that during menses. For women attending an infertility clinic, those with diagnosed polycystic ovarian syndrome indicated significantly (P < 0.0005) greater circulating INSL3 levels and those with low ovarian reserve showed significantly (P < 0.002) decrease
First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy
Thus, this first demonstration of a pregnancy from a heterotopic graft site provides unequivocal evidence that cryopreservation preserves complete follicle development and that normal ovarian function can occur at a non-ovarian site. This provides optimism for further efforts to assist women who have had oophorectomy and pelvic surgery or radiotherapy, without an appropriate orthotopic site for grafting
Follicular flushing and in vitro fertilization outcomes in the poorest responders: a randomized controlled trial
This is the first randomized trial to evaluate the utility of follicular flushing in the poorest responders, and the first to demonstrate a potentially detrimental effect of flushing on IVF outcomes.
Influence of cell loss after vitrification or slow-freezing on further in vitro development and implantation of human Day 3 embryos
Although it is not proved that vitrified embryos are more viable than slowly frozen embryos in terms of pregnancy outcome, vitrification yields higher survival rates, better overnight development and higher transfer rates per embryo warmed. This increases the number of frozen transfer cycles originating from a single treatment and might result in a better cumulative clinical outcome.
The time aspect in storing vitrified blastocysts: its impact on survival rate, implantation potential and babies born
We found that the storage of vitrified blastocysts in aseptic conditions neither impaired blastocyst viability (SR after warming during the first year of storage was 83.0% compared with 83.1% after 5–6 years of storage: NS) nor decreased pregnancy rates (clinical pregnancy rate after 1 year of storage was 40.0 versus 38.5% after 6 years: NS). In addition, no increase in the malformation rate over time was observed.
Multiple Birth Pregnancies Can Cost 20 Times More Than Singletons
Multiple pregnancies are a major public health concern in the United States and the rest of the world due to the significantly higher health risks for both mothers and infants, as well as the impact on healthcare costs. Investigators analyzed and compared the cost of multiple versus single-birth pregnancies and found that pregnancies with delivery of twins cost about five times more than singletons, and pregnancies with delivery of triplets or mo
Fertility Treatment Outcomes Influenced by Mother's Ethnicity
Maternal ethnicity is a significant determinant of successful outcomes after fertility treatment, suggests a new study published in BJOG: An International Journal of Obstetrics and Gynaecology.
Reproductive Biologists Move in Vitro Fertilization Knowledge Forward
Two new papers from reproductive biologists at the University of Massachusetts Amherst, with international partners, report advances in understanding the basic processes of sperm capacitation that may one day improve success rates of in vitro fertilization (IVF) by providing a shortcut to bypass problems, and may eventually lead to a male contraceptive.
Baby Boys at Higher Risk of Death, Disability in Preterm Births
Groundbreaking global studies on preterm birth and disability carried out by almost 50 researchers at 35 institutions and launched in association with World Prematurity Day finds baby boys are at a higher risk of death and disability due to preterm birth than baby girls. These disabilities range from learning problems and blindness to deafness and motor problems, including cerebral palsy.
Shanghai doctor tells local newspaper that two thirds of the city’s semen stocks are below World Health Organisation standards, as concerns over China’s toxic environment grow
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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