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Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma
As a result, we propose a simple two-biomarker decision tree for the differential diagnosis of OA and NOA and, in addition, for the differentiation of NOA subtypes. Clinical assays for ECM1 and TEX101 have the potential to replace most of the diagnostic testicular biopsies and facilitate the prediction of outcome of sperm retrieval procedures, thus increasing the reliability and success of assisted reproduction techniques.
Cyclophosphamide Triggers Follicle Activation and “Burnout”: AS101 Prevents Follicle Loss and Preserves Fertility
These findings suggest that the mechanism in Cy-induced loss of ovarian reserve is accelerated primordial follicle activation, which results in a “burnout” effect and follicle depletion. By preventing this activation, AS101 shows potential as an ovarian-protective agent, which may be able to preserve fertility in female cancer patients.
Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction in the Mouse
Sry is believed to function primarily in sex determination during fetal life. Eif2s3y may be the only Y chromosome gene required to drive mouse spermatogenesis, allowing formation of haploid germ cells that are functional in assisted reproduction. Our findings are relevant, but not directly translatable, to human male infertility cases.
Economics of assisted reproductive technology: data from an international analysis
Regarding the economic aspects of ART, the issue that remains to be faced and finally analyzed is the huge difference in the cost to patients for ART treatments across the world (i.e., between the United States and other developed countries) (3). Could the variations in cost of living alone justify the differences? Do clinics in some countries (i.e., the United States) offer different and higher technologies? What other factors might be involved?
Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species in granulosa cell
The results identify DA as a factor in the human ovary, which, via ROS generation, could play a role in ovarian physiology and pathology. The results obtained in samples from women with PCOS suggest the involvement of DA, acting via ROS, in this condition.
The expression and role of oxidative stress markers in the serum and follicular fluid of patients with endometriosis.
The ROS levels in both serum and follicular fluid of the study group were significantly higher than in the control group. The serum levels of SOD and VE in the study group were significantly lower than those in the control group, but there was no difference in follicular fluid levels of SOD and VE between the two groups. Furthermore, the mature oocyte and fertilization rates in the study group were significantly lower than those of the control gr
Single curettage endometrial biopsy injury in the proliferative phase improves reproductive outcome of subsequent in vitro fertilization-embryo transf
The clinical pregnancy rate (37.5% vs 12.2%), embryo implantation rate (23.6% vs 6.3%), and ongoing pregnancy rate (25.0% vs 8.2%) were significantly higher in the EBI group than in the non-EBI group. No serious complaints and complications were noted. CONCLUSION: Single curettage EBI in the proliferative phase of the preceding cycle significantly improved IVF-ET outcome in infertile patients with repeated EIF
Association between sequence variations in genes encoding human zona pellucida glycoproteins and fertilization failure in IVF
Our study on ZP genes of infertile women revealed a high degree of sequence variations. This may reflect gradual reduction of fertility among TFFs, but the putative roles and influences of single variations can only be hypothesized. [Note: given previous discussion in Embryomail on failed fertilisation, thsi 2005 paper supports a genetic co-factor suggesting ICSI is the preferred next treatment ed.]
The impact of legally restricted embryo transfer and reimbursement policy on cumulative delivery rate after treatment with assisted reproduction techn
The CDR within six cycles was 60 and 65.3% for study group and control group, respectively, for all ages, and 65.8 and 70.4%, respectively, in the subgroup younger than 36 years. In women ≥:36 years, CDR within six cycles was comparable in both groups (36–39 years, 43% in study versus 44.4% in control group, P = 0.730: 40–42 years, 21% in study versus 23% in control group, P = 0.786).
Delivery Rates Unaffected by Transferring Fewer Embryos, Reimbursing Six Cycles of Fertility Treatment
Research from Belgium has shown that if governments legislate to restrict the numbers of embryos transferred during fertility treatment, but combine it with a policy of reimbursing six cycles of assisted reproduction technology (ART), there is no detrimental impact on pregnancy and delivery rates. However, there is a greatly reduced risk of multiple births, which have associated health risks for mother and babies and are an increased cost to the
IVF: sex selection in Australia - should it be legal?
Sex selection is illegal in Australia, except under particular medical circumstances, so some Australians are heading overseas. It is argued that allowing the use of this technology for gender selection may be the first step down a 'slippery slope' toward 'designer babies': if sex selection was made legal, could parents then rightly be able to select for all kinds of traits in their children, such as hair colour, eye colour, or intelligence?
World's first test-tube baby pays emotional tribute to her parents for risking global condemnation to have her and pave the way for FIVE MILLION IVF b
Lesley and John Brown were the first people to successfully undergo IVF
Daughter Louise, now 35, born at Oldham General Hospital on July 25 1978
Birth attracted controversy and media attention from around the world
Lesley died in 2012 aged 64, with John dying several years earlier
Tree planted in their memory at Bourn Hall, Cambridgeshire, where IVF techniques were developed
Reproductive biologists move in vitro fertilization knowledge forward
2 new papers from reproductive biologists at UMass Amherst report advances in understanding the basic processes of sperm capacitation that may one day improve IVF success by bypassing early problems, and may lead to a male contraceptive
IVF technology is a widely accepted part of the story of reproduction in Australia - but where did it all begin? Dr John Leeton is a pioneer in this technology being described by colleagues as the “linchpin” of the IVF programme led by Monash University in Melbourne, Victoria. This program included the world’s first IVF pregnancy, many of the world’s earliest IVF babies, the world’s first donor egg baby and Australia’s first IVF surrogate pregnan
FertilityAuthority.com Debuts IVFAdvantage: Making IVF More Affordable for Everyone.
FertilityAuthority.com, LLC, the largest social media and online fertility patient resource in the world, announces the debut of IVFAdvantage, their multi-cycle IVF discount program for patients seeking In-Vitro Fertilization treatment. With IVFAdvantage, patients save up to 40% off on a treatment package that includes up to two fresh IVF cycles plus two frozen embryo transfer cycles and up to two years of frozen embryo storage. With many of Fert
Scientists have developed a non-invasive test that can predict whether men with zero sperm counts are capable of fathering children through IVF. Current methods rely on surgery to find out if a man has viable sperm that can be retrieved for fertility treatment.
Multiple births among mothers over 45 years old have increased by 16 per cent in the last year, partly fuelled by the use of IVF treatment by older women.
The rise comes despite official attempts to encourage clinics to reduce the number of embryos they use, to cut the numbers of multiple births, which come with higher health risks for both babies and mothers.
Two Y Genes Can Replace the Entire Y Chromosome for Assisted Reproduction in Mice
The Y chromosome is a symbol of maleness, present only in males and encoding genes important for male reproduction. But live mouse offspring can be generated with assisted reproduction using germ cells from males with the Y chromosome contribution limited to only two genes: the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y.
Scientists have practically obliterated the ultimate symbol of maleness in DNA, the Y chromosome, and believe they may be able to do away with it completely. They condensed all the genetic information normally found on a mouse's Y chromosome to just two genes. Their study, in the journal Science, showed the male mice could still father babies, albeit needing advanced IVF.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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