Comment:Several links between male age and health to the reproductive outcomes. An increasingly important risk factor that couples need to be counselled about.
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The relationship between male BMI and waist circumference on semen quality: data from the LIFE study
Body size (as measured by BMI or WC) is negatively associated with semen parameters with little influence of physical activity. Our findings are the first showing a relationship between WC and semen parameters in a sample of men without known infertility. Given the worldwide obesity epidemic, further study of the role of weight loss to improve semen parameters is warranted.
Uterine peristalsis exerts control over fluid migration after mock embryo transfer
Uterine peristalsis exerts control over embryo migration and could adversely affect the chances of pregnancy if the wave frequency is too high. It could be used as a predictor of uterine irritability before embryo transfer.
Effects of embryo culture media do not persist after implantation: a histological study in mice
Our data suggest that once implantation is achieved, subsequent post-implantation development unfolds normally, resulting in healthy fetuses. With mouse models, we gather information for the safety of human ART culture media. Our mouse study is reassuring for the safety of ART conditions on human embryonic development, given the lack of bold detrimental effects observed in the mouse model.
Environmental and developmental origins of ovarian reserve
Exposure to many environmental compounds, particularly to those that leach from plastics and other synthetic materials, is commonplace in modern societies to the extent that many are found at measurable concentrations in body fluids within most of the population. Relating fluid levels of individual compounds to parameters reflecting ovarian reserve in selected populations appears to be an effective way forward and, indeed, some early-stage findin
First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer pat
The immature oocytes recovered after oophorectomy were fertilized after IVM. The embryos obtained were cryopreserved and later transferred to achieve a singleton healthy pregnancy leading to a live birth.
What ‘misguided campaign’ against single embryo transfer?
A recent manuscript by Stillman et al. (2013) incorrectly accuses us of ‘a misguided campaign against the goal of SET and singleton birth in assisted reproduction (ART)’. They do so citing our repeatedly published opinion in various medical journals (including Human Reproduction: Gleicher and Barad, 2006, 2008, 2009, 2013: Gleicher, 2011, 2013a,b) that the currently almost indiscriminately propagated drive toward single embryo transfer (SET) is m
Ovarian sensitivity index is a better measure of ovarian responsiveness to gonadotrophin stimulation than the number of oocytes during in-vitro fertil
OSI is a better measure of ovarian responsiveness to gonadotrophin stimulation than the oocyte number, and is particularly useful when different subjects are treated with different stimulation regimens which would have confounding effect on the oocyte number
Analysis of in vitro fertilization data with multiple outcomes using discrete time-to-event analysis
We develop a general analysis framework based on a generalized linear modeling formulation that allows implementation of various types of models including shared frailty models, failure-specific frailty models, and transitional models, using standard software. We apply our methodology to data from an IVF study conducted at the Brigham and Women's Hospital, Massachusetts. We also summarize the performance of our proposed methods on the basis of a
Assisted Reproductive Technology Surveillance — United States, 2010. Surveillance Summaries
Reducing the number of embryos transferred per ART procedure among all age groups and promotion of eSET procedures, when clinically appropriate, is needed to reduce multiple births, including twin births, and related adverse consequences of ART. Improved patient education and counseling on the risks of twins might be useful in reducing twin births because twins account for the majority of multiples. Although ART contributes to increasing rates of
Advanced paternal age and mortality of offspring under 5 years of age: a register-based cohort study
The results suggest that the elevated risk for children of fathers aged 40 years or more was primarily attributed to an elevated risk of dying from congenital malformations, malignancies and external causes.
Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes
Paternal folate deficiency is associated with increased birth defects in the offspring, which include craniofacial and musculoskeletal malformations. - - This model suggests epigenetic transmission may involve sperm histone H3 methylation or DNA methylation and that adequate paternal dietary folate is essential for offspring health.
Although it accounted for just over 1% of U.S. births in 2005, assisted reproduction has fascinated the media and public. It has received less attention from lawmakers. In contrast to virtually every other developed nation, U.S. jurisdictions have enacted only piecemeal legislation to deal with assisted reproduction.
Marketing Loans for Fertility Treatments Raises Ethical Concern
An increase in the number of lenders specializing in loans for fertility treatments enables more people to afford the treatments, but it also raises ethical concerns, concludes a commentary in the Hastings Center Report. Among the concerns, doctors are marketing the loans to their patients, and some of these doctors have financial ties to specific lenders. The commentary calls for assessment and oversight of the practice.
You Are What Your Father Eats: Father's Diet Before Conception Plays Crucial Role in Offspring's Health, Study Suggests
Mothers get all the attention. But a study led by McGill researcher Sarah Kimmins suggests that the father's diet before conception may play an equally important role in the health of their offspring. It also raises concerns about the long-term effects of current Western diets and of food insecurity
World-renowned doctor who founded the McGill Reproductive Centre as a private clinic sues for a share of its profits, and also claims he was illegally dismissed
Mother at 64, woman delivers baby girl after trying for 41 years
Sixty-four-year-old Sarala Srivastava had been waiting for long - 41 years to be precise - for the miracle. The long wait finally ended last month with Sarala delivering a baby girl, a feat that made her a proud member of a select 60-plus mothers club from across the world.
American feminist Gloria Steinem famously observed that women were becoming the men they wanted to marry. In Australia, women are increasingly becoming the entire family too. The rapid rise in the number of single heterosexual Australian women using donor sperm to have a child - or children - has removed all but a man's DNA from the process of procreation.
Video Project Shared Via Social Media Gives Hope and Help to Couples Struggling with Infertility
Sher Fertility Institute is undertaking a project to bring awareness and attention to the topic of infertility, which affects an estimated one million people in the U.S. In the process, they are hoping to make the dreams of two infertile couples come true by providing them with free In Vitro Fertilization treatme
People who have embryos in storage for use in assisted reproductive treatment often find it difficult to decide what to do with the embryos when they are no longer receiving treatment. The ‘What to do with your unused embryos?’ brochure outlines the available options.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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