Comment:More links to publications describing the impact of time-lapse imagery on embryo grading. PLUS the release of two new EQA schemes for clinics using time-lapse imagery.
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Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution
We found that ~15% of human codons are dual-use codons (“duons”) that simultaneously specify both amino acids and TF recognition sites. Duons are highly conserved and have shaped protein evolution, and TF-imposed constraint appears to be a major driver of codon usage bias.
Compared with controls, embryos from hyperandrogenic PCOS patients were significantly delayed at 2PN breakdown, t2, t3, t4 and t7 but not at t5, t6, t8, tM or tB. Embryos from hyperandrogenic PCOS women had developed slower from fertilization to the 8-cell stage compared with embryos from controls.
Correlation between aneuploidy, apoptotic markers and DNA fragmentation in spermatozoa from normozoospermic patients
In conclusion, use of MACS reduced aneuploidy, DNA fragmentation and apoptosis. A postulated mechanism relating aneuploidy and DNA injury is discussed: on the contrary, cell death markers could not be related. An ‘apoptotic-like’ route could explain this situation.
First births with a simplified culture system for clinical IVF and embryo transfer
This study reports the outcome results from a pilot clinical trial using a simplified laboratory method for human IVF. This system reproducibly generates de novo the atmospheric and culture conditions that support normal fertilization and preimplantation embryogenesis to the hatched blastocyst stage without the need for specialized medical-grade gases or equipment. Development from insemination to the hatched blastocyst stage occurs undisturbed i
The human first cell cycle: impact on implantation
The timings at which second polar body extrusion (3.3–10.6 h), pronuclear fading (22.2–25.9 h) and length of S-phase (5.7–13.8 h) occurred were linked successfully to embryo implantation. The other parameters were apparently not related, as determined by image acquisition and time-lapse analysis.
Highlights: Whole-genome amplification and sequencing of single human oocytes using MALBAC method First comprehensive study of crossovers and genetic interference in human oocytes Phasing the genome of a female pronucleus by sequencing its polar bodies Selection of a viable egg without aneuploidy or point mutations by sequencing its polar bodies
The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive
The lowest risk for embryonic aneuploidy was between ages 26 and 30. Both younger and older age groups had higher rates of aneuploidy and an increased risk for more complex aneuploidies. The overall risk did not measurably change after age 43. Trisomies and monosomies are equally prevalent.. A slightly increased prevalence was noted at younger ages, with >40% aneuploidy in women 23 years and under
Complete method to obtain, culture, and transfer mouse blastocysts nonsurgically to study implantation and development
there are various bottlenecks in the procedure for obtaining and transferring murine embryos, which makes experimentation with this model more difficult. These difficulties include pseudopregnancy, ovarian hyperstimulation, and embryo collection, culture, and transfer. We have proposed a complete, efficient method for obtaining, culturing, and transferring mouse blastocysts that can be easily applied in research.
Cabergoline for the prevention of ovarian hyperstimulation syndrome: systematic review and meta-analysis of randomized controlled trials
Cabergoline reduces the occurrence of moderate-severe OHSS. Cabergoline is unlikely to have a clinically relevant negative impact on clinical pregnancy or on the number of retrieved oocytes. However, we are still uncertain of its impact on live birth, miscarriage, and congenital abnormalities.
Sperm selected by both birefringence and motile sperm organelle morphology examination have reduced deoxyribonucleic acid fragmentation
Sperm selection by birefringence or MSOME alone had one-third probability to select sperm with fragmented DNA. The lowest percentage of DNA fragmentation was found in birefringent sperm with no nuclear vacuoles and normal MSOME results. We suggest combining both methods using a single microscope and selecting sperm without nuclear vacuoles to get sperm with a higher chance of having intact DNA.
Freezing Semen Doubles Chances of Fatherhood for Men After Treatment for Hodgkin Lymphoma
Men with Hodgkin lymphoma who want to become fathers after their cancer treatment have greatly increased chances of doing so if they have frozen and stored semen samples beforehand, according to research published online in Europe's leading reproductive medicine journal Human Reproduction.
Scientists Discover Double Meaning in Genetic Code
Scientists have discovered a second code hiding within DNA. This second code contains information that changes how scientists read the instructions contained in DNA and interpret mutations to make sense of health and disease
New Method to Detect Genetic Defects in Egg Cells Could Double Success Rate of IVF
Through whole-genome sequencing of individual egg cells, the new method detects chromosomal abnormalities and DNA sequence variations associated with genetic disorders. `In this way, we kill two birds with one stone: one set of deep sequencing analysis to avoid two types of genetic problems,` says study author Jie Qiao of Third Hospital, Peking University. `Theoretically, if this works perfectly, we will be able to double the success rate of test
A 28-year-old woman in Madhya Pradesh has given birth to ten stillborn babies at 12 weeks of pregnancy. This is thought to be the highest number of children conceived from a single pregnancy, ever reported in the Indian medical history. {ed And the rest of the world is arguing over SET or DET!!!)
Allan Savory: How to fight desertification and reverse climate change
“Desertification is a fancy word for land that is turning to desert,” begins Allan Savory in this quietly powerful talk. And it's happening to about two-thirds of the world’s grasslands, accelerating climate change and causing traditional grazing societies to descend into social chaos. Savory has devoted his life to stopping it. He now believes - and his work so far shows - that a surprising factor can protect grasslands and even reclaim degraded
How do you control a spermbot? Try a magnetic field
TAKE bull sperm, mix in some nanotubes, and what do you get? Why the very first spermbot, of course. Eventually, these biobots could be used to shepherd individual sperm to eggs or to deliver targeted doses of drugs. Oliver Schmidt and colleagues at the Institute for Integrative Nanosciences in Dresden, Germany, combined individual sperm cells with tiny magnetic metal tubes to create the first sperm-based biobots.
Embryo Video Ranking: New for 2014. Developed for users of Time-lapse Embryo grading. [This link may be from a sponsor]
Comment = The release show videos of 4 embryos as visualised using an EmbryoScope unit. You are asked to rank these from best (1st) to least good (4th). Based upon the replies received, your ranking is calculated upon whether your selections agree with the majority of the other replies.
Evaluation of Cleavage by time lapse Imagery
[This link may be from a sponsor]
Comment = Evaluation of Cleavage by time lapse Imagery. The module uses videos from EmbryoScope as supplied by IVFA. When complete, there will be 12 releases, one per month in 2014. Each will show one video of the complete cleavage stages of a single human embryo. Participants will be as to assess the time to reach critical stages and to grade the final blastocyst.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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