Comment:This weekly list contains a link to an Adelaide report on IVF outcomes, some news reports on the IVF lottery that exists in the UK, story of conjoint whales!! and some reports on birthweight after extended culture and FET. Enjoy. Note, A new Free, anonymous IVF clinic database and KPI management tool is being developed. INTERESTED?
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Large baby syndrome in singletons born after frozen embryo transfer (FET): is it due to maternal factors or the cryotechnique?
Are singletons born after frozen embryo transfer (FET) at increased risk of being born large for gestational age (LGA) and if so, is this caused by intrinsic maternal factors or related to the freezing/thawing procedures? - Hence, the increased risk of LGA in FET singletons cannot solely be explained by being the second born or by intrinsic maternal factors, but may also partly be related to freezing/thawing procedures per se.
Effect of in vitro culture period on birthweight of singleton newborns
Our study suggests that a prolonged (5–6 days) in vitro culture period has a significant effect on the mean absolute birthweight and Z scores of singleton newborns. The effect of prolonged in vitro culture on epigenetic changes in the embryo needs further study.-The absolute birthweight for singletons resulting from blastocyst transfer was significantly greater than singletons resulting from Day 3 transfer (3465.31 ± 51.36 versus 3319.82 ± 10.04
No evidence that embryo selection by near-infrared spectroscopy in addition to morphology is able to improve live birth rates: results from an individ
There is at present no evidence that NIR spectroscopy of spent embryo culture media in its current form can be used in daily practice to improve live birth rates.
Updated assays for inhibin B and AMH provide evidence for regular episodic secretion of inhibin B but not AMH in the follicular phase of the normal me
These data suggest different regulatory mechanisms for InhB and AMH secretion, and confirm an ‘aging ovary’ pattern of AMH and InhB secretion, which is consistent with decreased ovarian reserve. We also demonstrated comparability of the AMH Gen II assay with the previous version in standard usage but our data raised concerns about comparability of the InhB Gen II assay.
Is ovarian hyperstimulation associated with higher blood pressure in 4-year-old IVF offspring? Part I: multivariable regression analysis
Our findings are in line with other studies describing adverse effects of IVF on cardiometabolic outcome but this is the first study suggesting that ovarian hyperstimulation, as used in IVF treatments, could be a causative mechanism. Perhaps ovarian hyperstimulation negatively influences cardiometabolic outcome via changes in the early environment of the oocyte and/or embryo that result in epigenetic modifications of key metabolic systems that a
Continuous high-dose estrogen controls serum FSH and LH levels: new treatment strategy for extremely low ovarian reserve patients, two case reports.
After cycle cancellation and unsuccessful IVF treatment, both patients received conjugated estrogen (CE) supplementation (2.5–3.75 :mg/day) from day 2 of their menstrual cycle to the day of HCG administration in their IVF treatment cycles. Following continuous high-dose estrogen supplementation, oocytes were successfully retrieved from both patients and fertilized. Both patients also achieved ongoing pregnancy through frozen–thawed embryo tr
Cryopreservation of day 2–3 embryos by vitrification yields better outcome than slow freezing.
Embryo survival rate was significantly higher after vitrification compared with slow freezing (81.6%, 647/793 versus 70.0%, 393/562 embryos, p :< :0.0001). The clinical pregnancy rate per ET was significantly higher following vitrification compared to slow freezing, 20.0%, 63/314 versus 11.9%, 23/193, respectively (p := :0.02). Conclusions: Vitrification of day 2–3 cleavage stage embryos yields better cycle outcome in all the
Perinatal Outcomes by Mode of Assisted Conception and Sub-Fertility in an Australian Data Linkage Cohort
Births after assisted conception show an extensive range of compromised outcomes that vary by treatment modality, that are substantially reduced after embryo freezing, but which co-occur with an increased risk of macrosomia.
'Exceptionally rare' conjoined gray whale calves found in Mexico's Ojo de Liebre lagoon
Fishermen have found two "exceptionally rare" conjoined gray whale calves in a lagoon in Mexico. The four-metre Siamese whales were dead when they were discovered in the Ojo de Liebre lagoon, which opens into the Pacific Ocean in the Baja California peninsula.
Study highlights increased risks of stillbirth from assisted conception methods including IVF
Babies conceived by assisted reproductive therapies including IVF are almost twice as likely to be stillborn than those who are conceived naturally, an Australian study has found. Researchers at the University of Adelaide's Robinson Institute compared more than 300,000 births in South Australia over 17 years.
Study Dispels Theories of Y Chromosome's Demise: Stripped-Down Chromosome Retains Key Genes for Fertility
A comparison of Y chromosomes in eight African and eight European men dispels the common notion that the Y's genes are mostly unimportant and that the chromosome is destined to dwindle and disappear. The Y chromosome has lost 90 percent of the genes it once shared with the X chromosome, and some scientists have speculated that the Y chromosome will disappear in less than 5 million years," said evolutionary biologist Melissa A. Wilson Sayres, a Mi
Capturing a Hard-Wired Variability: What Makes Some Identical Twins Noticeably Different?
A Ludwig Cancer Research study has uncovered a phenomenon that alters prevailing views of how the genome is expressed to make and sustain the life of mammals. Published in the journal Science, the paper helps explain why genetically identical animals are sometimes so different in their biology and appearance, and why some inherited disorders caused by a shared set of aberrant genes can be of such variable severity in different people.
Serious complications are twice as high for babies conceived by assisted reproductive therapies. Almost 40,000 live births occur in the U.S. each year using assisted reproductive technologies. Fertility treatment is associated with increased risk of major birth defects, which varies between in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), and is significantly reduced by embryo freezing.
Dr. Michael Davies, MPH, PhD, prof
Joy as IVF rejection overturned after funding blunder
A woman told she could not have IVF treatment because she was single has now been told the decision was made in error. Sarah Darlington, 38, was heartbroken after being told she was not eligible for fertility treatment on the NHS because she does not have a partner.
Bolton couple considered moving house to get IVF treatment in 'postcode lottery'
Guidance from NICE (National Institute for Health and Clinical Excellence) recommends that up to three IVF cycles should be available on the NHS if the woman is aged between 23 and 39 at the time of treatment, and one or both partners has been diagnosed with a fertility problem.
OvaScience Announces Global Healthcare Strategist Marc Kozin Joins Company's Board of Directors
"OvaScience's technology has the potential to improve female fertility, and the value of its EggPC(SM) platform could have broader applications in other areas including human and animal health," said Mr. Kozin. "I look forward to working with OvaScience to get innovative and much needed products to patients as soon as possible."
Evaluation of Cleavage by time lapse Imagery
[This link may be from a sponsor]
Comment = Evaluation of Cleavage by time lapse Imagery. The module uses videos from EmbryoScope as supplied by IVFA. When complete, there will be 12 releases, one per month in 2014. Each will show one video of the complete cleavage stages of a single human embryo. Participants will be as to assess the time to reach critical stages and to grade the final blastocyst.
Embryo Video Ranking: New for 2014. Developed for users of Time-lapse Embryo grading. [This link may be from a sponsor]
Comment = The release show videos of 4 embryos as visualised using an EmbryoScope unit. You are asked to rank these from best (1st) to least good (4th). Based upon the replies received, your ranking is calculated upon whether your selections agree with the majority of the other replies.
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
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