Comment:Mainly journal links. News from the UK on saviour siblings, and a great link to blastocyst biopsy from RI. Plus links to the use of analgesics in pregnancy, aneuploidy in blastocysts....
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The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender
Morphology and aneuploidy are linked at the blastocyst stage. However, the association is weak, and consequently, morphologic analysis cannot be relied on to ensure transfer of chromosomally normal embryos. A signifi:cant proportion of aneuplo
Dual effects of superovulation: loss of maternal and paternal imprinted methylation in a dose-depend
We postulate that superovulation has dual effects during oogenesis, disrupting acquisition of imprints in growing oocytes, as well as maternal-effect gene products subsequently required for imprint maintenance during pre-implantation development.
Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient p
The aetiology of DNA damage in spermatozoa involves a cascade of changes that progress from the induction of oxidative stress and oxidized DNA base adduct formation to DNA fragmentation and cell death. Preparation of spermatozoa on discontinuous dens
Nuclear staining identifies two populations of human sperm with different DNA fragmentation extent a
Sperm DNA fragmentation is a possible predictive parameter for male fertility status. The occurrence of M540 bodies in semen of subfertile subjects affects flow cytometric investigations in sperm. We set up a new method to evaluate DNA fragmentation
Efficiency of polarized microscopy as a predictive tool for human oocyte quality- Hum Reprod
CONCLUSIONS Oocytes with absent spindles were associated with lower fertilization rates and advanced female age. Other important outcome parameters (embryo quality, pregnancy rates) were not correlated to spindle nor zona inner layer analysis
BBC News - Male sex hormone testosterone `interferes with empathy`
Giving women a small dose of the male sex hormone testosterone makes them less able to empathise with others, say UK and Dutch researchers. Their findings, in journal PNAS, add weight to the theory that the hormone is significant in the development
Differential transcriptomic profile in spermatozoa achieving pregnancy or not via ICSI
Our findings showed profound differences, including a large amount of transcripts that were differentially expressed in the two groups. A subsequent functional analysis of these differentially expressed genes showed that many of them are involved in
Improvements in identification of the best sperm for ICSI?
Benefits for infertile couples are provided by more thorough assessment of individual sperm morphology prior to ICSI – but regrettably this approach is not widely used, the reluctance being possibly cost-related or the lingering feeling that there is
Poor response cycles: when should we cancel? Comparison of outcome between egg collection, intrauter
Our data suggest that for such poor responders, proceeding to VEC may represent their best chance of successful outcome. Conversion to IUI offers the poorest outcome, and despite the potential for improvements in cycle protocol, abandoning and a furt
The effect of paternal age on assisted reproduction outcome
In conclusion, the available retrospective data suggest that advancing paternal age is not associated with decreased ART outcomes, including pregnancy rate, miscarriage rate, and live birth rate. However, it is important to note that the only prospec
Prolonged use of paracetamol and other painkillers during pregnancy may pose a health risk to baby boys, warn experts. Danish research suggests the drugs raise the risk of undescended testicles in male babies, a condition linked to infertility and c
BBC News - Sheffield mother to freeze eggs for infertile daughter
A mother from Sheffield plans to freeze her own eggs to enable her infertile two-year-old daughter to have children in later life. Mackenzie Jarvis was born with Turner Syndrome, a chromosome abnormality which causes infertility.
BBC News - Professor Simon Fishel: `Saviour siblings a positive medicine`
eading fertility doctor and managing director of the CARE Fertility Group, Professor Simon Fishel has welcomed the UK's first `saviour sibling` treatment as `positive medicine
BBC News - UKs first `saviour sibling` treats sister
The first treatment involving a so-called `saviour sibling` has been carried out in the UK. Max Matthews was conceived through IVF to be a genetically selected match suitable to transplant bone marrow to his sister Megan, who suffers from fanconi an
EQA scheme for Follicular AMH [This link may be from a sponsor]
An EQA scheme to estimate the Follicular Phase Serum AntiMullarian Hormone concentration. Ten samples to be analysed between February and November 2011 containing 0.8-1.0 ml serum from multiple women during the follicular phase of IVF treatment. The
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
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