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Polar body array CGH for prediction of the status of the corresponding oocyte. Part II: technical as
CONCLUSIONS Special care has to be taken with respect to the timing of biopsy of the PB2. Mechanical- and laser-assisted biopsy give the same performance in terms of diagnostic efficiency.
Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical resu
CONCLUSIONS This proof-of-principle study indicates that the ploidy of the zygote can be predicted with acceptable accuracy by array CGH analysis of both PBs.
Clinical use of a model to predict the viability of early intrauterine pregnancies when no embryo is
Maternal age, gestational sac diameter (GSD) and serum progesterone levels were used in a logistic regression model to create an algorithm for estimation of the probability of a viable pregnancy.
Successful childbirth after intracytoplasmic morphologically selected sperm injection without assist
Considering these results, a single IMSI cycle was performed, and spermatozoa were selected for the absence of vacuoles and the presence of a small bud of acrosome. A comparable fertilization rate with or without calcium-ionophore AOA was observed.
Editorial commentary: Progesterone and spermatozoa: a long-lasting liaison comes to definition
This year, two major breakthroughs in the literature have better defined the interaction between the fertilizing spermatozoon and progesterone, which is present throughout the female genital tract.
Role of zonadhesin during sperm-egg interaction: a species-specific
acrosomal molecule wit
Here we describe the cellular and molecular interaction of zonadhesin during fertilization and propose a model in which sperm could transiently expose acrosomal molecules that adhere to the zona independently of the AR in a ‘kiss and run’ mechanism.
Highly purified spermatozoal RNA obtained by a novel method indicates an unusual 28S/18S rRNA ratio
Using a novel two-round column-based protocol for human ejaculates delivering highly purified spermatozoal RNA, we uncovered a heterogeneous, but specific banding pattern in microelectrophoresis with 28S ribosomal RNA being indicative for the amount
Development of ovarian hyperstimulation syndrome: interrogation of key proteins and biological proce
The delineation of such processes may allow the development of informed corrective therapeutic intervention in patients at risk of OHSS and a set of key proteins of the FF may be helpful as potential biomarkers for monitoring IVF therapy.
Anti-Müllerian hormone—is it a crystal ball for predicting ovarian ageing?
However, widespread use of AMH for indications not proved by evidence-based medicine can lead to either false reassurance or distress, leading to unnecessary medical interventions . It also has huge implications for costs. We evaluated the evidence b
Sperm storage for cancer patients in the UK: a review of current practice
Most adult and adolescent patients and their relatives/ spouses/ parents/ guardians value this service even though very few eventually use the sperm. There is an urgent need to develop national and international guidelines for the provision, organiz
Premature Babies at Risk of Ill Health in Later Life, Research Suggests
ScienceDaily (Oct. 18, 2011) — Young adults who were born prematurely show multiple biological signs of risks to future health, research from Imperial College London has found. The scientists, say that the research indicates that urgent work is now n
Faulty Molecular Switch Can Cause Infertility or Miscarriage
ScienceDaily (Oct. 17, 2011) — Scientists have discovered an enzyme that acts as a 'fertility switch', in a study published in Nature Medicine on October 16. High levels of the protein are associated with infertility, while low levels make a woman mo
Europe's top court has banned patenting any stem cell process that involves destroying a human embryo, dealing what some scientists said was a "devastating" blow to an emerging field of medical research. Researchers fear the ruling by the European Co
Egg donor compensation is to triple under new HFEA guidelines
The UK's fertility watchdog has agreed to triple the compensation given to women who donate eggs to help infertile couples to have a child. Donors currently have their expenses paid and up to £250 to cover lost earnings. The Human Fertilisation and E
It produces many bundles of joy but also wrapped up in the IVF scenario is the often agonising decision about what to do with unused embryos.
Join Rosemarie Milsom online to discuss this subject at the Newcastle Herald website, theherald.com.au.
WOMEN considering freezing their eggs for social reasons would be better off settling for ''Mr Not-Quite-Right'' as a father sooner rather than later, a leading IVF specialist says. While many fertility clinics are starting to spruik egg freezing to
Women With Polycystic Ovary Syndrome at Increased Risk of Pregnancy Complications, Research Finds
ScienceDaily (Oct. 14, 2011) — Women with polycystic ovary syndrome are more likely to have problems with pregnancy regardless of whether they are undergoing fertility treatment, claims new research published on the British Medical Journal website.
Evidence and models of best practice should guide recruitment of gamete donors
Appeared in BioNews 629-We welcome much of what Dr Kamal Ahuja wrote in his recent BioNews commentary 'If it ain't broke, don't fix it.'. Like him, we believe there is no good evidence to demonstrate that paying 'donors' would increase the supply of
Female fertility may be improved by breast cancer risk gene
Appeared in BioNews 629 - A genetic mutation known to increase a woman's risk of cancer could also increase their fertility, research suggests. Women with mutations in the BRCA1 or BRCA2 genes, which are associated with a higher risk of breast and ov
Women as young as 18 searching for sperm donors online
Appeared in BioNews 629- Increasing numbers of women under the age of 25 are turning to sperm donors online, an investigation by the Sunday Times has shown. Many of these women have stable jobs and good support networks, and see no reason to wait bef
Biologists Describe Key Mechanism in Early Embryo Development
ScienceDaily (Oct. 20, 2011) — New York University and University of Iowa biologists have identified a key mechanism controlling early embryonic development that is critical in determining how structures such as appendages - arms and legs in humans -
Quantitative expression of phospholipase C zeta, as an index to assess fertilization potential of a
In this study, for the first time, we have shown that assessment of relative expression of PLCζ::: may provide a useful marker for the ability of sperm to induce oocyte activation after ICSI.
sperm from a patient with globozoospermia, examined by motile sperm organelle morphology examination
The cover of Human Reproduction shows sperm from a patient with globozoospermia, examined by motile sperm organelle morphology examination (MSOME: panels a and b) and transmission electron microscopy (TEM: panels c and d). In this patient 1% of sperm
Model explaining incompatibility between sperm and egg receptors
Mol Hum Reprod - The front cover shows Putative model explaining incompatibility between sperm and egg receptors. ZP is represented in blue, sperm membranes in violet and zonadhesin splice variants in red. Different shapes of zonadhesin represent di
The front cover shows a working model of the regulation of oocyte gene expression.
The front cover shows a working model of the regulation of oocyte gene expression. It shows the SOHLH1/2 complex, which is believed to be master-master regulators of other master transcription factors. Key downstream transcription targets are also sh
In-line filter for cylinder and house gasses
O2, N2, CO2, and tri-gas. Aire~LifeLine provides in-line air filtration with top of the line protection, delivering a better and more consistent yield of cylinder and house gasses for a wide range of med
Vit Kit - Warm NX is an adaptable, cost-effective system for use in the thawing of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Unlike many vitrification kits that feature a mono-buffered system and M199 base med
Vit Kit - Freeze NX is an adaptable, cost-effective system for use in the vitrification of oocytes, pronuclear zygotes, cleavage stage embryos, and blastocyst stage embryos. Vit Kit - Freeze NX is the latest advancement in vitrification media aimed t
S-Cryolock is the slimmer version of the original. It is a versatile, simple and efficient vitrification device that is intended for the holding, cryopreservation and storage of oocytes or embryos in liquid nitrogen.
Source
Irvine Scientific
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